Vitamin D supplementation in the healthy pediatric population

Objective: To review the current scientific evidence on the efficacy of universal vitamin D supplementation in healthy children with no risk factors and to propose updated modifications to the recommendations provided in the main clinical practice guidelines. Methods: Scoping review through a litera...

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Autores: González Jiménez, David, Rodríguez Delgado, Juan, Campoy, Cristina, Galera Martínez, Rafael, Gil Campos, Mercedes, Redecillas Ferreiro, Susana, Saenz de Pipaón, Miguel, Leis Trabazo, María Rosaura
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/45171
Acceso en línea:https://hdl.handle.net/10347/45171
Access Level:acceso abierto
Palabra clave:Vitamin D
Supplementation
Healthy child
320613 Vitaminas
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spelling Vitamin D supplementation in the healthy pediatric populationSuplementación con vitamina D en población pediátrica sanaGonzález Jiménez, DavidRodríguez Delgado, JuanCampoy, CristinaGalera Martínez, RafaelGil Campos, MercedesRedecillas Ferreiro, SusanaSaenz de Pipaón, MiguelLeis Trabazo, María RosauraVitamin DSupplementationHealthy child320613 VitaminasObjective: To review the current scientific evidence on the efficacy of universal vitamin D supplementation in healthy children with no risk factors and to propose updated modifications to the recommendations provided in the main clinical practice guidelines. Methods: Scoping review through a literature search conducted in PubMed for articles published in English or Spanish in the past 15 years using the following MeSH search terms: (vitamin D) AND (supplementation). The search yielded 2133 articles, of which 22 were selected. Results: In infants aged less than 1 year without risk factors, administration of 400 IU/day improves serum levels of calcifediol, but most studies have not found an association with improved bone health assessed by dual-energy X-ray absorptiometry. In children aged more than 1 year with calcifediol levels of less than 35 ng/mL, supplementation with 400 to 800 IU/day of vitamin D decreases the risk of respiratory infection. There is still no evidence in the pediatric population that vitamin D supplementation either decreases the risk or severity of other infections or offers any other clinically significant extraskeletal benefits. Conclusion: Based on the main clinical practice guidelines, supplementation with vitamin D at a dose of 400 IU/day is recommended for breastfed infants aged less than 1 year or infants who do not achieve the recommended daily intake through infant formula. In children aged more than 1 year, supplementation should be individualized.Elsevier España, S.L.U.Universidade de Santiago de Compostela. Departamento de Ciencias Forenses, Anatomía Patolóxica, Xinecoloxía e Obstetricia, e Pediatría20252025-06-1420252025-06-14journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10347/45171reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2© 2025 Published by Elsevier España, S.L.U. on behalf of Asociación Española de Pediatría. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/451712026-06-15T12:47:27Z
dc.title.none.fl_str_mv Vitamin D supplementation in the healthy pediatric population
Suplementación con vitamina D en población pediátrica sana
title Vitamin D supplementation in the healthy pediatric population
spellingShingle Vitamin D supplementation in the healthy pediatric population
González Jiménez, David
Vitamin D
Supplementation
Healthy child
320613 Vitaminas
title_short Vitamin D supplementation in the healthy pediatric population
title_full Vitamin D supplementation in the healthy pediatric population
title_fullStr Vitamin D supplementation in the healthy pediatric population
title_full_unstemmed Vitamin D supplementation in the healthy pediatric population
title_sort Vitamin D supplementation in the healthy pediatric population
dc.creator.none.fl_str_mv González Jiménez, David
Rodríguez Delgado, Juan
Campoy, Cristina
Galera Martínez, Rafael
Gil Campos, Mercedes
Redecillas Ferreiro, Susana
Saenz de Pipaón, Miguel
Leis Trabazo, María Rosaura
author González Jiménez, David
author_facet González Jiménez, David
Rodríguez Delgado, Juan
Campoy, Cristina
Galera Martínez, Rafael
Gil Campos, Mercedes
Redecillas Ferreiro, Susana
Saenz de Pipaón, Miguel
Leis Trabazo, María Rosaura
author_role author
author2 Rodríguez Delgado, Juan
Campoy, Cristina
Galera Martínez, Rafael
Gil Campos, Mercedes
Redecillas Ferreiro, Susana
Saenz de Pipaón, Miguel
Leis Trabazo, María Rosaura
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de Santiago de Compostela. Departamento de Ciencias Forenses, Anatomía Patolóxica, Xinecoloxía e Obstetricia, e Pediatría
dc.subject.none.fl_str_mv Vitamin D
Supplementation
Healthy child
320613 Vitaminas
topic Vitamin D
Supplementation
Healthy child
320613 Vitaminas
description Objective: To review the current scientific evidence on the efficacy of universal vitamin D supplementation in healthy children with no risk factors and to propose updated modifications to the recommendations provided in the main clinical practice guidelines. Methods: Scoping review through a literature search conducted in PubMed for articles published in English or Spanish in the past 15 years using the following MeSH search terms: (vitamin D) AND (supplementation). The search yielded 2133 articles, of which 22 were selected. Results: In infants aged less than 1 year without risk factors, administration of 400 IU/day improves serum levels of calcifediol, but most studies have not found an association with improved bone health assessed by dual-energy X-ray absorptiometry. In children aged more than 1 year with calcifediol levels of less than 35 ng/mL, supplementation with 400 to 800 IU/day of vitamin D decreases the risk of respiratory infection. There is still no evidence in the pediatric population that vitamin D supplementation either decreases the risk or severity of other infections or offers any other clinically significant extraskeletal benefits. Conclusion: Based on the main clinical practice guidelines, supplementation with vitamin D at a dose of 400 IU/day is recommended for breastfed infants aged less than 1 year or infants who do not achieve the recommended daily intake through infant formula. In children aged more than 1 year, supplementation should be individualized.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-06-14
2025
2025-06-14
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10347/45171
url https://hdl.handle.net/10347/45171
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier España, S.L.U.
publisher.none.fl_str_mv Elsevier España, S.L.U.
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
repository.name.fl_str_mv
repository.mail.fl_str_mv
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