Vitamin D supplementation in the healthy pediatric population

Objective: To review the current scientific evidence on the efficacy of universal vitamin D supplementation in healthy children with no risk factors and to propose updated modifications to the recommendations provided in the main clinical practice guidelines. Methods: Scoping review through a litera...

Descripción completa

Detalles Bibliográficos
Autores: González Jiménez, David, Rodríguez Delgado, Juan, Campoy, Cristina, Galera Martínez, Rafael, Gil Campos, Mercedes, Redecillas Ferreiro, Susana, Saenz de Pipaón, Miguel, Leis Trabazo, María Rosaura
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/45171
Acceso en línea:https://hdl.handle.net/10347/45171
Access Level:acceso abierto
Palabra clave:Vitamin D
Supplementation
Healthy child
320613 Vitaminas
Descripción
Sumario:Objective: To review the current scientific evidence on the efficacy of universal vitamin D supplementation in healthy children with no risk factors and to propose updated modifications to the recommendations provided in the main clinical practice guidelines. Methods: Scoping review through a literature search conducted in PubMed for articles published in English or Spanish in the past 15 years using the following MeSH search terms: (vitamin D) AND (supplementation). The search yielded 2133 articles, of which 22 were selected. Results: In infants aged less than 1 year without risk factors, administration of 400 IU/day improves serum levels of calcifediol, but most studies have not found an association with improved bone health assessed by dual-energy X-ray absorptiometry. In children aged more than 1 year with calcifediol levels of less than 35 ng/mL, supplementation with 400 to 800 IU/day of vitamin D decreases the risk of respiratory infection. There is still no evidence in the pediatric population that vitamin D supplementation either decreases the risk or severity of other infections or offers any other clinically significant extraskeletal benefits. Conclusion: Based on the main clinical practice guidelines, supplementation with vitamin D at a dose of 400 IU/day is recommended for breastfed infants aged less than 1 year or infants who do not achieve the recommended daily intake through infant formula. In children aged more than 1 year, supplementation should be individualized.