Analysis of craniocervical abnormalities in osteogenesis imperfecta during growth

Osteogenesis Imperfecta (OI) is a genetic disease characterized by osteopenia and bone fragility in which the craniocervical junction is also affected. This is of special relevance due to the high prevalence in anomalies described in the literature as follows: basilar invagination, basilar impressio...

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Detalles Bibliográficos
Autores: Nova García, Manuel Joaquín De, García de Sola, Rafael, Burgueño Torres, Laura
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/102394
Acceso en línea:https://hdl.handle.net/20.500.14352/102394
Access Level:acceso abierto
Palabra clave:616.314-053.2
615.849
616.71
572.72
Osteogenesis imperfecta
Craniocervical junction
Platybasia
Basilar impression
Basilar invagination
Magnetic resonance imaging
Ciencias Biomédicas
Odontología (Medicina)
Odontología infantil
Diagnóstico por imagen y medicina nuclear
32 Ciencias Médicas
3207.14 Osteopatología
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oai_identifier_str oai:docta.ucm.es:20.500.14352/102394
network_acronym_str ES
network_name_str España
repository_id_str
spelling Analysis of craniocervical abnormalities in osteogenesis imperfecta during growthNova García, Manuel Joaquín DeGarcía de Sola, RafaelBurgueño Torres, Laura616.314-053.2615.849616.71572.72Osteogenesis imperfectaCraniocervical junctionPlatybasiaBasilar impressionBasilar invaginationMagnetic resonance imagingCiencias BiomédicasOdontología (Medicina)Odontología infantilDiagnóstico por imagen y medicina nuclear32 Ciencias Médicas3207.14 OsteopatologíaOsteogenesis Imperfecta (OI) is a genetic disease characterized by osteopenia and bone fragility in which the craniocervical junction is also affected. This is of special relevance due to the high prevalence in anomalies described in the literature as follows: basilar invagination, basilar impression, and platybasia. Methods. We analyzed 19 lateral skull radiographs and 14 magnetic resonance images (MRIs) of 28 patients with OI in which eight linear and five angular measurements were plotted to determine the existence of craniocervical junction anomalies and compare them with 38 lateral skull radiographs and 28 MRIs performed on age-matched healthy controls. Results. From the reference values obtained from the control sample for each age group, we established the limit value at which pathology could be suspected. Some of the variables studied showed a clear trend associated with growth. More than half of the patients (60.71%) presented an anomaly in the skull base. Conclusions. According to the diagnostic criteria used and taking +2.5 SD as the limit value, 10.71% of the patients had basilar invagination, 35.71% had basilar impression, and 39.29% had platybasia, the latter being the most common findingMDPIUniversidad Complutense de Madrid20242024-02-1820242024-02-18journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/102394reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1023942026-06-02T12:44:21Z
dc.title.none.fl_str_mv Analysis of craniocervical abnormalities in osteogenesis imperfecta during growth
title Analysis of craniocervical abnormalities in osteogenesis imperfecta during growth
spellingShingle Analysis of craniocervical abnormalities in osteogenesis imperfecta during growth
Nova García, Manuel Joaquín De
616.314-053.2
615.849
616.71
572.72
Osteogenesis imperfecta
Craniocervical junction
Platybasia
Basilar impression
Basilar invagination
Magnetic resonance imaging
Ciencias Biomédicas
Odontología (Medicina)
Odontología infantil
Diagnóstico por imagen y medicina nuclear
32 Ciencias Médicas
3207.14 Osteopatología
title_short Analysis of craniocervical abnormalities in osteogenesis imperfecta during growth
title_full Analysis of craniocervical abnormalities in osteogenesis imperfecta during growth
title_fullStr Analysis of craniocervical abnormalities in osteogenesis imperfecta during growth
title_full_unstemmed Analysis of craniocervical abnormalities in osteogenesis imperfecta during growth
title_sort Analysis of craniocervical abnormalities in osteogenesis imperfecta during growth
dc.creator.none.fl_str_mv Nova García, Manuel Joaquín De
García de Sola, Rafael
Burgueño Torres, Laura
author Nova García, Manuel Joaquín De
author_facet Nova García, Manuel Joaquín De
García de Sola, Rafael
Burgueño Torres, Laura
author_role author
author2 García de Sola, Rafael
Burgueño Torres, Laura
author2_role author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 616.314-053.2
615.849
616.71
572.72
Osteogenesis imperfecta
Craniocervical junction
Platybasia
Basilar impression
Basilar invagination
Magnetic resonance imaging
Ciencias Biomédicas
Odontología (Medicina)
Odontología infantil
Diagnóstico por imagen y medicina nuclear
32 Ciencias Médicas
3207.14 Osteopatología
topic 616.314-053.2
615.849
616.71
572.72
Osteogenesis imperfecta
Craniocervical junction
Platybasia
Basilar impression
Basilar invagination
Magnetic resonance imaging
Ciencias Biomédicas
Odontología (Medicina)
Odontología infantil
Diagnóstico por imagen y medicina nuclear
32 Ciencias Médicas
3207.14 Osteopatología
description Osteogenesis Imperfecta (OI) is a genetic disease characterized by osteopenia and bone fragility in which the craniocervical junction is also affected. This is of special relevance due to the high prevalence in anomalies described in the literature as follows: basilar invagination, basilar impression, and platybasia. Methods. We analyzed 19 lateral skull radiographs and 14 magnetic resonance images (MRIs) of 28 patients with OI in which eight linear and five angular measurements were plotted to determine the existence of craniocervical junction anomalies and compare them with 38 lateral skull radiographs and 28 MRIs performed on age-matched healthy controls. Results. From the reference values obtained from the control sample for each age group, we established the limit value at which pathology could be suspected. Some of the variables studied showed a clear trend associated with growth. More than half of the patients (60.71%) presented an anomaly in the skull base. Conclusions. According to the diagnostic criteria used and taking +2.5 SD as the limit value, 10.71% of the patients had basilar invagination, 35.71% had basilar impression, and 39.29% had platybasia, the latter being the most common finding
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-02-18
2024
2024-02-18
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/102394
url https://hdl.handle.net/20.500.14352/102394
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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