Can Adding Constitutive Receptor Activity Redefine Biased Signaling Quantification?
Biased signaling, the differential activation of distinct signaling pathways, is currently at the center of pharmacology. Reliable characterization of biased ligands requires robust scales applicable to all ligand classes: agonists, neutral antagonists, and inverse agonists. To this end, constitutiv...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:306807 |
| Acceso en línea: | https://ddd.uab.cat/record/306807 https://dx.doi.org/urn:doi:10.1016/j.tips.2019.01.002 |
| Access Level: | acceso abierto |
| Palabra clave: | Constitutive receptor activity Biased signaling GPCR Inverse agonists |
| Sumario: | Biased signaling, the differential activation of distinct signaling pathways, is currently at the center of pharmacology. Reliable characterization of biased ligands requires robust scales applicable to all ligand classes: agonists, neutral antagonists, and inverse agonists. To this end, constitutive receptor activity should be included in the models. |
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