Clinical relevance of interictal dysphoric disorder and its impact on quality of life in drug-resistant epilepsy

Objective: This study aims to assess the prevalence of Interictal Dysphoric Disorder (IDD) in drug-resistant epilepsy (DRE) and to describe its clinical and psychopathological profile, including personality, as well as its impact on quality of life (QOL). Method: A retrospective cross-sectional stud...

Descripción completa

Detalles Bibliográficos
Autores: Monteagudo-Gimeno, Eila, Sánchez-González, Roberto, Radua, Joaquim, Fortea-González, Lydia, Boget Llucià, Teresa, Carreño Martínez, Mar, Donaire Pedraza, Antonio J., Bargalló Alabart, Núria, Setoain Perego, Xavier, Rumià Arboix, Jordi, Bulbena Vilarrasa, Antonio, Pintor-Pérez, Luis
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/59300
Acceso en línea:http://hdl.handle.net/10230/59300
http://dx.doi.org/10.1016/j.yebeh.2023.109253
Access Level:acceso abierto
Palabra clave:Drug-Resistant Epilepsy
Interictal Dysphoric Disorder
Psychopathology
Descripción
Sumario:Objective: This study aims to assess the prevalence of Interictal Dysphoric Disorder (IDD) in drug-resistant epilepsy (DRE) and to describe its clinical and psychopathological profile, including personality, as well as its impact on quality of life (QOL). Method: A retrospective cross-sectional study from an Epilepsy Unit from January 2007 to December 2017. All patients were diagnosed with DRE. Patients underwent a battery of tests (HADS, SCL-90R, PDQ-4+, QOLIE-31) and a psychiatrist assessed the presence of Axis-I disorders and IDD. Statistical procedures were carried out using R-4.0.1 software. Results: A total of 282 patients were included. A statistically significant association was found between IDD and mood and anxiety disorders (p < 0.001 and p < 0.05 respectively), and between IDD and higher scores in all HADS and SCL-90-R items compared to subjects without IDD (p < 0.001). A statistically significant association was also found between IDD and obsessive-compulsive, borderline and depressive personality disorder (p < 0.05). Scores in all QOLIE-31 items except for 'medication effects' were significantly lower in subjects with IDD compared with subjects without IDD (p < 0.001). Conclusions: In DRE, IDD subjects show differences in the psychopathological profile and QOL scores compared to subjects without a diagnosis of IDD. An early diagnosis of IDD could facilitate prompt interventions which might positively impact QOL.

Similares en LA Referencia