Relevance of the epigenetic regulation exercised by hepatic microRNAs in the fatty liver arena: from the bedside to the bench
Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver disease worldwide, involving a spectrum of disturbances mainly characterized by fatty acid infiltration and fat deposition in the liver parenchyma. Given that alterations in epigenetic mechanisms have been associ...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | CBUC, CESCA |
| Repositorio: | TDR. Tesis Doctorales en Red |
| OAI Identifier: | oai:www.tdx.cat:10803/671499 |
| Acceso en línea: | http://hdl.handle.net/10803/671499 |
| Access Level: | acceso abierto |
| Palabra clave: | MicroRNAs Non-alcoholic fatty liver disease (NAFLD) Fatty liver Fetge gras Hígado graso Epigenetics Epigenètica Epigenética Metabolism Metabolisme Triglycerides Triglicèrids Triglicéridos Chronic liver diseases Malalties hepàtiques cròniques Enfermedades epáticas crónicas 575 616.3 |
| Sumario: | Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver disease worldwide, involving a spectrum of disturbances mainly characterized by fatty acid infiltration and fat deposition in the liver parenchyma. Given that alterations in epigenetic mechanisms have been associated with hepatic metabolic disorders, we focused on the relevance of microRNAs (miRNAs) in the pathophysiology of NAFLD. In this thesis, an analysis of hepatic miRNAs comparing patients with and without NAFLD has shown that the disease is associated with an altered miRNA profile, and that the expression of specific miRNAs is related to changes in gene expression and impaired glucose and lipid metabolism. Additionally, altered regulation of miRNAs has been demonstrated through modulation of AMPK in cell and animal models. Finally, specific miRNAs were observed to partially rescued fatty acid overload and modified lipid profiles within hepatocytes, stressing their potential as epigenetic regulators to combat NAFLD |
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