Untargeted Metabolomic Study of Lung Cancer Patients after Surgery with Curative Intent

Sánchez-Espirilla, Saida; Pereira-Vega, Antonio; Callejón-Leblic, Belén; Díaz-Olivares, Isabel; Santana, Rafael; Gotera-Rivera, Carolina; Gómez-Ariza, José L.; López-Campos, J. L.; Blanco-Orozco, Ana Isabel; Seijo, Luis; Rodríguez, María; Padrón Fraysse, Luis Alejandro; Herrera-Chilla, Ángeles; Peces-Barba, Germán; García-Barrera, Tamara

Untargeted Metabolomic Study of Lung Cancer Patients after Surgery with Curative Intent

Detalles Bibliográficos
Autores:	Sánchez-Espirilla, Saida, Pereira-Vega, Antonio, Callejón-Leblic, Belén, Díaz-Olivares, Isabel, Santana, Rafael, Gotera-Rivera, Carolina, Gómez-Ariza, José L., López-Campos, J. L., Blanco-Orozco, Ana Isabel, Seijo, Luis, Rodríguez, María, Padrón Fraysse, Luis Alejandro, Herrera-Chilla, Ángeles, Peces-Barba, Germán, García-Barrera, Tamara
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2023
País:	España
Institución:	Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:	DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:	oai:digital.csic.es:10261/353448
Acceso en línea:	http://hdl.handle.net/10261/353448
Access Level:	acceso abierto
Palabra clave:	Metabolomics Mass spectrometry Hydrophilic interaction Lung cancer Serum Surgery Ultra-high performance liquid chromatography

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spelling	Untargeted Metabolomic Study of Lung Cancer Patients after Surgery with Curative IntentSánchez-Espirilla, SaidaPereira-Vega, AntonioCallejón-Leblic, BelénDíaz-Olivares, IsabelSantana, RafaelGotera-Rivera, CarolinaGómez-Ariza, José L.López-Campos, J. L.Blanco-Orozco, Ana IsabelSeijo, LuisRodríguez, MaríaPadrón Fraysse, Luis AlejandroHerrera-Chilla, ÁngelesPeces-Barba, GermánGarcía-Barrera, TamaraMetabolomicsMass spectrometryHydrophilic interactionLung cancerSerumSurgeryUltra-high performance liquid chromatography© 2023 The Authors. Published by American Chemical Society. This publication is licensed under CC-BY 4.0.Lung cancer (LC) is a leading cause of mortality, claiming more than 1.8 million deaths per year worldwide. Surgery is one of the most effective treatments when the disease is in its early stages. The study of metabolic alterations after surgical intervention with curative intent could be used to assess the response to treatment or the detection of cancer recurrence. In this study, we have evaluated the metabolomic profile of serum samples (n = 110) from preoperative (PRE) and postoperative (POST) LC patients collected at two different time points (1 month, A; 3–6 months, B) with respect to healthy people. An untargeted metabolomic platform based on reversed phase (RP) and hydrophilic interaction chromatography (HILIC), using ultra-high performance liquid chromatography (UHPLC) and mass spectrometry (MS), was applied (MassIVE ID MSV000092213). Twenty-two altered metabolites were annotated by comparing all the different studied groups. DG(14,0/22:1), stearamide, proline, and E,e-carotene-3,3′-dione were found altered in PRE, and their levels returned to those of a baseline control group 3–6 months after surgery. Furthermore, 3-galactosyllactose levels remained altered after intervention in some patients. This study provides unique insights into the metabolic profiles of LC patients after surgery at two different time points by combining complementary analytical methods.This work has been supported by the project “Heteroatom-tagged proteomics and metabolomics to study LC. Influence of gut microbiota' (Ref.: PY20_00366). Project of Excellence. Regional Ministry of Economy, Knowledge, Business and University, Andalusia, Spain. The authors also thank the grants Ref. 651/2018 and 115/2020 from the Spanish Society of Pneumology and Surgery (SEPAR) and 08/2018 from the Association of Pneumology and Thoracic Surgery (Neumosur) that supported sample recruitment at the hospitals and biobank registration. The authors also thank the Instituto de Salud Carlos III (AES16/01783) and unrestricted funding from the Menarini Group. Funding for open access charge: Universidad de Huelva/CBUA.Peer reviewedAmerican Chemical SocietyJunta de AndalucíaSociedad Española de Neumología y Cirugía TorácicaAsociación de Neumología y Cirugía Torácica del Sur (España)Instituto de Salud Carlos IIIGrupo MenariniUniversidad de HuelvaConsorcio de Bibliotecas Universitarias de AndalucíaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/353448reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1021/acs.jproteome.3c00356Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3534482026-05-22T06:33:51Z
dc.title.none.fl_str_mv	Untargeted Metabolomic Study of Lung Cancer Patients after Surgery with Curative Intent
title	Untargeted Metabolomic Study of Lung Cancer Patients after Surgery with Curative Intent
spellingShingle	Untargeted Metabolomic Study of Lung Cancer Patients after Surgery with Curative Intent Sánchez-Espirilla, Saida Metabolomics Mass spectrometry Hydrophilic interaction Lung cancer Serum Surgery Ultra-high performance liquid chromatography
title_short	Untargeted Metabolomic Study of Lung Cancer Patients after Surgery with Curative Intent
title_full	Untargeted Metabolomic Study of Lung Cancer Patients after Surgery with Curative Intent
title_fullStr	Untargeted Metabolomic Study of Lung Cancer Patients after Surgery with Curative Intent
title_full_unstemmed	Untargeted Metabolomic Study of Lung Cancer Patients after Surgery with Curative Intent
title_sort	Untargeted Metabolomic Study of Lung Cancer Patients after Surgery with Curative Intent
dc.creator.none.fl_str_mv	Sánchez-Espirilla, Saida Pereira-Vega, Antonio Callejón-Leblic, Belén Díaz-Olivares, Isabel Santana, Rafael Gotera-Rivera, Carolina Gómez-Ariza, José L. López-Campos, J. L. Blanco-Orozco, Ana Isabel Seijo, Luis Rodríguez, María Padrón Fraysse, Luis Alejandro Herrera-Chilla, Ángeles Peces-Barba, Germán García-Barrera, Tamara
author	Sánchez-Espirilla, Saida
author_facet	Sánchez-Espirilla, Saida Pereira-Vega, Antonio Callejón-Leblic, Belén Díaz-Olivares, Isabel Santana, Rafael Gotera-Rivera, Carolina Gómez-Ariza, José L. López-Campos, J. L. Blanco-Orozco, Ana Isabel Seijo, Luis Rodríguez, María Padrón Fraysse, Luis Alejandro Herrera-Chilla, Ángeles Peces-Barba, Germán García-Barrera, Tamara
author_role	author
author2	Pereira-Vega, Antonio Callejón-Leblic, Belén Díaz-Olivares, Isabel Santana, Rafael Gotera-Rivera, Carolina Gómez-Ariza, José L. López-Campos, J. L. Blanco-Orozco, Ana Isabel Seijo, Luis Rodríguez, María Padrón Fraysse, Luis Alejandro Herrera-Chilla, Ángeles Peces-Barba, Germán García-Barrera, Tamara
author2_role	author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Junta de Andalucía Sociedad Española de Neumología y Cirugía Torácica Asociación de Neumología y Cirugía Torácica del Sur (España) Instituto de Salud Carlos III Grupo Menarini Universidad de Huelva Consorcio de Bibliotecas Universitarias de Andalucía Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv	Metabolomics Mass spectrometry Hydrophilic interaction Lung cancer Serum Surgery Ultra-high performance liquid chromatography
topic	Metabolomics Mass spectrometry Hydrophilic interaction Lung cancer Serum Surgery Ultra-high performance liquid chromatography
description	© 2023 The Authors. Published by American Chemical Society. This publication is licensed under CC-BY 4.0.
publishDate	2023
dc.date.none.fl_str_mv	2023 2024 2024
dc.type.none.fl_str_mv	info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 Publisher's version info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/10261/353448
url	http://hdl.handle.net/10261/353448
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	https://doi.org/10.1021/acs.jproteome.3c00356 Sí
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	American Chemical Society
publisher.none.fl_str_mv	American Chemical Society
dc.source.none.fl_str_mv	reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str	Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str	DIGITAL.CSIC. Repositorio Institucional del CSIC
collection	DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,81155

Untargeted Metabolomic Study of Lung Cancer Patients after Surgery with Curative Intent

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