Untargeted Metabolomic Study of Lung Cancer Patients after Surgery with Curative Intent

Lung cancer (LC) is a leading cause of mortality, claiming more than 1.8 million deaths per year worldwide. Surgery is one of the most effective treatments when the disease is in its early stages. The study of metabolic alterations after surgical intervention with curative intent could be used to as...

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Detalhes bibliográficos
Autores: Rodríguez-Pérez, M.C. (María C.)|||/items/e7a4053b-ce80-4e0b-b37b-afbe3a88081b, Sánchez-Espirilla, S. (Saida)|||/items/5095a919-1058-4806-8114-497455613e0f, Pereira-Vega, A. (Antonio)|||/items/14146d6d-e3fc-4f70-8f1e-acad429bcdab, Callejón-Leblic, B. (Belén)|||/items/6dd79d23-1874-4a72-ad68-5e1c6167c251, Díaz-Olivares, I. (Isabel)|||/items/446b3b26-7f5a-4ff7-9d32-73143a9c24d5, Santana, R. (Rafael)|||/items/3445ede9-80bb-4529-843a-1738945d6546, Gotera-Rivera, C. (Carolina)|||/items/3432e1ae-ecd8-4a95-a5cc-dc45251ca9ec, Gómez-Ariza, J. L. (José Luis)|||/items/1c23fcfe-e2dc-4274-aaa5-8037e2bf569e, Lopez-Campos, J.L. (José Luis)|||/items/bd4db85b-f394-4a29-95cb-9ff4c4991f1b, Blanco-Orozco, A. I. (Ana Isabel)|||/items/61810eca-6cf8-4148-ad3f-fb83960ac003, Seijo, L. (Luis)|||/items/abfac499-8cb5-4c80-9152-88309b94a9ae, Padrón-Fraysse, L. A. (Luis Alejandro)|||/items/cf76ca10-3620-4d97-9983-bf954a940262, Herrera-Chilla, A. (Ángeles)|||/items/7fe4f748-299a-410d-8364-9344abae5b0b, Peces-Barba, G. (German)|||/items/7662852e-3d6a-4253-82d1-cff18ab0aa14, García-Barrera, T. (Tamara)|||/items/2a05b899-f65d-445a-ba8d-9ab71c49c676
Tipo de documento: artigo
Data de publicação:2023
País:España
Recursos:Universidad de Navarra
Repositório:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglês
OAI Identifier:oai:dadun.unav.edu:10171/69032
Acesso em linha:https://hdl.handle.net/10171/69032
Access Level:Acceso aberto
Palavra-chave:Metabolomics
Mass spectrometry
Hydrophilic interaction
Lung cancer
Serum
Surgery
Ultra-high performance liquid chromatography
Descrição
Resumo:Lung cancer (LC) is a leading cause of mortality, claiming more than 1.8 million deaths per year worldwide. Surgery is one of the most effective treatments when the disease is in its early stages. The study of metabolic alterations after surgical intervention with curative intent could be used to assess the response to treatment or the detection of cancer recurrence. In this study, we have evaluated the metabolomic profile of serum samples (n = 110) from preoperative (PRE) and postoperative (POST) LC patients collected at two different time points (1 month, A; 3–6 months, B) with respect to healthy people. An untargeted metabolomic platform based on reversed phase (RP) and hydrophilic interaction chromatography (HILIC), using ultra-high performance liquid chromatography (UHPLC) and mass spectrometry (MS), was applied (MassIVE ID MSV000092213). Twenty-two altered metabolites were annotated by comparing all the different studied groups. DG(14,0/22:1), stearamide, proline, and E,e-carotene-3,3′-dione were found altered in PRE, and their levels returned to those of a baseline control group 3–6 months after surgery. Furthermore, 3-galactosyllactose levels remained altered after intervention in some patients. This study provides unique insights into the metabolic profiles of LC patients after surgery at two different time points by combining complementary analytical methods.

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