Association of circulating microRNAs with coronary artery disease and usefulness for reclassification of healthy individuals: The REGICOR study

Producción Científica

Detalles Bibliográficos
Autores: Dégano, Irene R., Camps Vilaró, Anna, Subirana, Isaac, García Mateo, Nadia, Cidad Velasco, María Del Pilar, Muñoz Aguayo, Daniel, Puigdecanet, Eulàlia, Nonell, Lara, Vila, Joan, Crepaldi, Felipe M., Gonzalo Calvo, David de, Llorente Cortés, Vicenta, Pérez García, María Teresa, Elosua, Roberto, Fitó, Montserrat, Marrugat, Jaume
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Valladolid
Repositorio:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/44469
Acceso en línea:https://doi.org/10.3390/jcm9051402
http://uvadoc.uva.es/handle/10324/44469
Access Level:acceso abierto
Palabra clave:Arterias coronarias - Enfermedades
Lipoproteins
Lipoproteínas
MicroRNAs
MicroARNs
Myocardial infarction
Infarto de miocardio
3205.01 Cardiología
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spelling Association of circulating microRNAs with coronary artery disease and usefulness for reclassification of healthy individuals: The REGICOR studyDégano, Irene R.Camps Vilaró, AnnaSubirana, IsaacGarcía Mateo, NadiaCidad Velasco, María Del PilarMuñoz Aguayo, DanielPuigdecanet, EulàliaNonell, LaraVila, JoanCrepaldi, Felipe M.Gonzalo Calvo, David deLlorente Cortés, VicentaPérez García, María TeresaElosua, RobertoFitó, MontserratMarrugat, JaumeArterias coronarias - EnfermedadesLipoproteinsLipoproteínasMicroRNAsMicroARNsMyocardial infarctionInfarto de miocardio3205.01 CardiologíaProducción CientíficaRisk prediction tools cannot identify most individuals at high coronary artery disease (CAD) risk. Oxidized low-density lipoproteins (oxLDLs) and microRNAs are actively involved in atherosclerosis. Our aim was to examine the association of CAD and oxLDLs-induced microRNAs, and to assess the microRNAs predictive capacity of future CAD events. Human endothelial and vascular smooth muscle cells were treated with oxidized/native low-density lipoproteins, and microRNA expression was analyzed. Differentially expressed and CAD-related miRNAs were examined in serum samples from (1) a case-control study with 476 myocardial infarction (MI) patients and 487 controls, and (2) a case-cohort study with 105 incident CAD cases and 455 randomly-selected cohort participants. MicroRNA expression was analyzed with custom OpenArray plates, log rank tests and Cox regression models. Twenty-one microRNAs, two previously undescribed (hsa-miR-193b-5p and hsa-miR-1229-5p), were up- or down-regulated upon cell treatment with oxLDLs. One of the 21, hsa-miR-122-5p, was also upregulated in MI cases (fold change = 4.85). Of the 28 CAD-related microRNAs tested, 11 were upregulated in MI cases-1 previously undescribed (hsa-miR-16-5p)-, and 1/11 was also associated with CAD incidence (adjusted hazard ratio = 0.55 (0.35–0.88)) and improved CAD risk reclassification, hsa-miR-143-3p. We identified 2 novel microRNAs modulated by oxLDLs in endothelial cells, 1 novel microRNA upregulated in AMI cases compared to controls, and one circulating microRNA that improved CAD risk classification.Fondo Europeo de Desarrollo Regional (projects FIS-CP12/03287, FIS-14/00449, FIS-PI081327, INTRASALUD PI11/01801, PI15/00064, IJCI-2016-29393 to DdG-C, CIBERCV (CB16/11/00229, 00246, 00403), CIBERESP CB06/02/0029 and CIBEROBN CB06/03/0028)Ministerio de Economía, Industria y Competitividad (project BFU2016-75360-R)Fundación BBVA (project PR-16-BIO-CAR-0041)Departament de Salut de la Generalitat de Catalunya - Agència de Gestió d’Ajuts Universitaris de Recerca de Catalunya (project 2017SGR222)Pla estratègic de recerca i innovació en salut (project SLT006/17/00234, SLT002/16/00145 and SLT006/17/00029)Junta de Castilla y León (project VA114P17)MPDI2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.3390/jcm9051402http://uvadoc.uva.es/handle/10324/44469reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidIngléshttps://www.mdpi.com/2077-0383/9/5/1402info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:uvadoc.uva.es:10324/444692026-06-13T12:44:47Z
dc.title.none.fl_str_mv Association of circulating microRNAs with coronary artery disease and usefulness for reclassification of healthy individuals: The REGICOR study
title Association of circulating microRNAs with coronary artery disease and usefulness for reclassification of healthy individuals: The REGICOR study
spellingShingle Association of circulating microRNAs with coronary artery disease and usefulness for reclassification of healthy individuals: The REGICOR study
Dégano, Irene R.
Arterias coronarias - Enfermedades
Lipoproteins
Lipoproteínas
MicroRNAs
MicroARNs
Myocardial infarction
Infarto de miocardio
3205.01 Cardiología
title_short Association of circulating microRNAs with coronary artery disease and usefulness for reclassification of healthy individuals: The REGICOR study
title_full Association of circulating microRNAs with coronary artery disease and usefulness for reclassification of healthy individuals: The REGICOR study
title_fullStr Association of circulating microRNAs with coronary artery disease and usefulness for reclassification of healthy individuals: The REGICOR study
title_full_unstemmed Association of circulating microRNAs with coronary artery disease and usefulness for reclassification of healthy individuals: The REGICOR study
title_sort Association of circulating microRNAs with coronary artery disease and usefulness for reclassification of healthy individuals: The REGICOR study
dc.creator.none.fl_str_mv Dégano, Irene R.
Camps Vilaró, Anna
Subirana, Isaac
García Mateo, Nadia
Cidad Velasco, María Del Pilar
Muñoz Aguayo, Daniel
Puigdecanet, Eulàlia
Nonell, Lara
Vila, Joan
Crepaldi, Felipe M.
Gonzalo Calvo, David de
Llorente Cortés, Vicenta
Pérez García, María Teresa
Elosua, Roberto
Fitó, Montserrat
Marrugat, Jaume
author Dégano, Irene R.
author_facet Dégano, Irene R.
Camps Vilaró, Anna
Subirana, Isaac
García Mateo, Nadia
Cidad Velasco, María Del Pilar
Muñoz Aguayo, Daniel
Puigdecanet, Eulàlia
Nonell, Lara
Vila, Joan
Crepaldi, Felipe M.
Gonzalo Calvo, David de
Llorente Cortés, Vicenta
Pérez García, María Teresa
Elosua, Roberto
Fitó, Montserrat
Marrugat, Jaume
author_role author
author2 Camps Vilaró, Anna
Subirana, Isaac
García Mateo, Nadia
Cidad Velasco, María Del Pilar
Muñoz Aguayo, Daniel
Puigdecanet, Eulàlia
Nonell, Lara
Vila, Joan
Crepaldi, Felipe M.
Gonzalo Calvo, David de
Llorente Cortés, Vicenta
Pérez García, María Teresa
Elosua, Roberto
Fitó, Montserrat
Marrugat, Jaume
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Arterias coronarias - Enfermedades
Lipoproteins
Lipoproteínas
MicroRNAs
MicroARNs
Myocardial infarction
Infarto de miocardio
3205.01 Cardiología
topic Arterias coronarias - Enfermedades
Lipoproteins
Lipoproteínas
MicroRNAs
MicroARNs
Myocardial infarction
Infarto de miocardio
3205.01 Cardiología
description Producción Científica
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.3390/jcm9051402
http://uvadoc.uva.es/handle/10324/44469
url https://doi.org/10.3390/jcm9051402
http://uvadoc.uva.es/handle/10324/44469
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://www.mdpi.com/2077-0383/9/5/1402
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MPDI
publisher.none.fl_str_mv MPDI
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
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