Autonomic response to walk tests is useful for assessing outcome measures in people with multiple sclerosis

Objective: The aim of this study was to evaluate the association between changes in the autonomic control of cardiorespiratory system induced by walk tests and outcome measures in people with Multiple Sclerosis (pwMS).Methods: Electrocardiogram (ECG) recordings of 148 people with Relapsing-Remitting...

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Autores: Kontaxis, Spyridon, Laporta, Estela, Garcia, Esther, Guerrero, Ana Isabel, Zabalza, Ana, Matteo, Martinis, Lucia, Roselli, Simblett, Sara, Weyer, Janice, Hotopf, Matthew, Narayan, Vaibhav A., Rashid, Zulqarnain, Folarin, Amos A., Dobson, Richard J. B., Buron, Mathias Due, Leocani, Letizia, Cummins, Nicholas, Vairavan, Srinivasan, Costa, Gloria Dalla, Magyari, Melinda, Sørensen, Per Soelberg, Nos, Carlos, Bailón, Raquel, Comi, Giancarlo, the RADAR-CNS Consortium
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universidad de Zaragoza
Repositorio:Zaguán. Repositorio Digital de la Universidad de Zaragoza
OAI Identifier:oai:zaguan.unizar.es:126425
Acceso en línea:http://zaguan.unizar.es/record/126425
Access Level:acceso abierto
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spelling Autonomic response to walk tests is useful for assessing outcome measures in people with multiple sclerosisKontaxis, SpyridonLaporta, EstelaGarcia, EstherGuerrero, Ana IsabelZabalza, AnaMatteo, MartinisLucia, RoselliSimblett, SaraWeyer, JaniceHotopf, MatthewNarayan, Vaibhav A.Rashid, ZulqarnainFolarin, Amos A.Dobson, Richard J. B.Buron, Mathias DueLeocani, LetiziaCummins, NicholasVairavan, SrinivasanCosta, Gloria DallaMagyari, MelindaSørensen, Per SoelbergNos, CarlosBailón, RaquelComi, Giancarlothe RADAR-CNS ConsortiumObjective: The aim of this study was to evaluate the association between changes in the autonomic control of cardiorespiratory system induced by walk tests and outcome measures in people with Multiple Sclerosis (pwMS).Methods: Electrocardiogram (ECG) recordings of 148 people with Relapsing-Remitting MS (RRMS) and 58 with Secondary Progressive MS (SPMS) were acquired using a wearable device before, during, and after walk test performance from a total of 386 periodical clinical visits. A subset of 90 participants repeated a walk test at home. Various MS-related symptoms, including fatigue, disability, and walking capacity were evaluated at each clinical visit, while heart rate variability (HRV) and ECG-derived respiration (EDR) were analyzed to assess autonomic nervous system (ANS) function. Statistical tests were conducted to assess differences in ANS control between pwMS grouped based on the phenotype or the severity of MS-related symptoms. Furthermore, correlation coefficients (r) were calculated to assess the association between the most significant ANS parameters and MS-outcome measures.Results: People with SPMS, compared to RRMS, reached higher mean heart rate (HRM) values during walk test, and larger sympathovagal balance after test performance. Furthermore, pwMS who were able to adjust their HRM and ventilatory values, such as respiratory rate and standard deviation of the ECG-derived respiration, were associated with better clinical outcomes. Correlation analyses showed weak associations between ANS parameters and clinical outcomes when the Multiple Sclerosis phenotype is not taken into account. Blunted autonomic response, in particular HRM reactivity, was related with worse walking capacity, yielding r = 0.36 r = 0.29 (RRMS) and r > 0.5 (SPMS). A positive strong correlation r > 0.7 r > 0.65 between cardiorespiratory parameters derived at hospital and at home was also found.Conclusion: Autonomic function, as measured by HRV, differs according to MS phenotype. Autonomic response to walk tests may be useful for assessing clinical outcomes, mainly in the progressive stage of MS. Participants with larger changes in HRM are able to walk longer distance, while reduced ventilatory function during and after walk test performance is associated with higher fatigue and disability severity scores. Monitoring of disorder severity could also be feasible using ECG-derived cardiac and respiratory parameters recorded with a wearable device at home.2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://zaguan.unizar.es/record/126425reponame:Zaguán. Repositorio Digital de la Universidad de Zaragozainstname:Universidad de ZaragozaInglésinfo:eu-repo/grantAgreement/EC/H2020/115902This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 115902-RADAR-CNSinfo:eu-repo/grantAgreement/EUR/MICINN/TED2021-131106B-I00info:eu-repo/semantics/openAccessoai:zaguan.unizar.es:1264252026-05-29T13:59:51Z
dc.title.none.fl_str_mv Autonomic response to walk tests is useful for assessing outcome measures in people with multiple sclerosis
title Autonomic response to walk tests is useful for assessing outcome measures in people with multiple sclerosis
spellingShingle Autonomic response to walk tests is useful for assessing outcome measures in people with multiple sclerosis
Kontaxis, Spyridon
title_short Autonomic response to walk tests is useful for assessing outcome measures in people with multiple sclerosis
title_full Autonomic response to walk tests is useful for assessing outcome measures in people with multiple sclerosis
title_fullStr Autonomic response to walk tests is useful for assessing outcome measures in people with multiple sclerosis
title_full_unstemmed Autonomic response to walk tests is useful for assessing outcome measures in people with multiple sclerosis
title_sort Autonomic response to walk tests is useful for assessing outcome measures in people with multiple sclerosis
dc.creator.none.fl_str_mv Kontaxis, Spyridon
Laporta, Estela
Garcia, Esther
Guerrero, Ana Isabel
Zabalza, Ana
Matteo, Martinis
Lucia, Roselli
Simblett, Sara
Weyer, Janice
Hotopf, Matthew
Narayan, Vaibhav A.
Rashid, Zulqarnain
Folarin, Amos A.
Dobson, Richard J. B.
Buron, Mathias Due
Leocani, Letizia
Cummins, Nicholas
Vairavan, Srinivasan
Costa, Gloria Dalla
Magyari, Melinda
Sørensen, Per Soelberg
Nos, Carlos
Bailón, Raquel
Comi, Giancarlo
the RADAR-CNS Consortium
author Kontaxis, Spyridon
author_facet Kontaxis, Spyridon
Laporta, Estela
Garcia, Esther
Guerrero, Ana Isabel
Zabalza, Ana
Matteo, Martinis
Lucia, Roselli
Simblett, Sara
Weyer, Janice
Hotopf, Matthew
Narayan, Vaibhav A.
Rashid, Zulqarnain
Folarin, Amos A.
Dobson, Richard J. B.
Buron, Mathias Due
Leocani, Letizia
Cummins, Nicholas
Vairavan, Srinivasan
Costa, Gloria Dalla
Magyari, Melinda
Sørensen, Per Soelberg
Nos, Carlos
Bailón, Raquel
Comi, Giancarlo
the RADAR-CNS Consortium
author_role author
author2 Laporta, Estela
Garcia, Esther
Guerrero, Ana Isabel
Zabalza, Ana
Matteo, Martinis
Lucia, Roselli
Simblett, Sara
Weyer, Janice
Hotopf, Matthew
Narayan, Vaibhav A.
Rashid, Zulqarnain
Folarin, Amos A.
Dobson, Richard J. B.
Buron, Mathias Due
Leocani, Letizia
Cummins, Nicholas
Vairavan, Srinivasan
Costa, Gloria Dalla
Magyari, Melinda
Sørensen, Per Soelberg
Nos, Carlos
Bailón, Raquel
Comi, Giancarlo
the RADAR-CNS Consortium
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
description Objective: The aim of this study was to evaluate the association between changes in the autonomic control of cardiorespiratory system induced by walk tests and outcome measures in people with Multiple Sclerosis (pwMS).Methods: Electrocardiogram (ECG) recordings of 148 people with Relapsing-Remitting MS (RRMS) and 58 with Secondary Progressive MS (SPMS) were acquired using a wearable device before, during, and after walk test performance from a total of 386 periodical clinical visits. A subset of 90 participants repeated a walk test at home. Various MS-related symptoms, including fatigue, disability, and walking capacity were evaluated at each clinical visit, while heart rate variability (HRV) and ECG-derived respiration (EDR) were analyzed to assess autonomic nervous system (ANS) function. Statistical tests were conducted to assess differences in ANS control between pwMS grouped based on the phenotype or the severity of MS-related symptoms. Furthermore, correlation coefficients (r) were calculated to assess the association between the most significant ANS parameters and MS-outcome measures.Results: People with SPMS, compared to RRMS, reached higher mean heart rate (HRM) values during walk test, and larger sympathovagal balance after test performance. Furthermore, pwMS who were able to adjust their HRM and ventilatory values, such as respiratory rate and standard deviation of the ECG-derived respiration, were associated with better clinical outcomes. Correlation analyses showed weak associations between ANS parameters and clinical outcomes when the Multiple Sclerosis phenotype is not taken into account. Blunted autonomic response, in particular HRM reactivity, was related with worse walking capacity, yielding r = 0.36 r = 0.29 (RRMS) and r > 0.5 (SPMS). A positive strong correlation r > 0.7 r > 0.65 between cardiorespiratory parameters derived at hospital and at home was also found.Conclusion: Autonomic function, as measured by HRV, differs according to MS phenotype. Autonomic response to walk tests may be useful for assessing clinical outcomes, mainly in the progressive stage of MS. Participants with larger changes in HRM are able to walk longer distance, while reduced ventilatory function during and after walk test performance is associated with higher fatigue and disability severity scores. Monitoring of disorder severity could also be feasible using ECG-derived cardiac and respiratory parameters recorded with a wearable device at home.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://zaguan.unizar.es/record/126425
url http://zaguan.unizar.es/record/126425
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/EC/H2020/115902
This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 115902-RADAR-CNS
info:eu-repo/grantAgreement/EUR/MICINN/TED2021-131106B-I00
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv
publisher.none.fl_str_mv
dc.source.none.fl_str_mv reponame:Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname:Universidad de Zaragoza
instname_str Universidad de Zaragoza
reponame_str Zaguán. Repositorio Digital de la Universidad de Zaragoza
collection Zaguán. Repositorio Digital de la Universidad de Zaragoza
repository.name.fl_str_mv
repository.mail.fl_str_mv
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