Bacterial co-infection at hospital admission in patients with COVID-19

Moreno García, Estela; Puerta-Alcalde, Pedro; Letona Giménez, Laura; Meira, Fernanda; Dueñas, Gerard; Chumbita, Mariana; García Pouton, Nicole; Monzó Gallo, Patricia; Lopera, Carlos; Serra, Laia; Cardozo Espinola, Celia; Hernández Meneses, Marta; Rico, Verónica; Bodro, Marta; Morata, Laura; Fernández Pittol, Mariana José; Grafia, Ignacio; Castro Rebollo, Pedro; Mensa Pueyo, Josep; Martínez, José Antonio; Sanjuan, Gemma; Marcos, Ma. Angeles; Soriano Viladomiu, Alex; Garcia Vidal, Carolina; Hospital Clinic of Barcelona COVID-19 Research Group

Bacterial co-infection at hospital admission in patients with COVID-19

Objectives: We described the current incidence and risk factors of bacterial co-infection in hospitalized patients with COVID-19. Methods: Observational cohort study was performed at the Hospital Clinic of Barcelona (February 2020-February 2021). All patients with COVID-19 who were admitted for &...

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Autores:	Moreno García, Estela, Puerta-Alcalde, Pedro, Letona Giménez, Laura, Meira, Fernanda, Dueñas, Gerard, Chumbita, Mariana, García Pouton, Nicole, Monzó Gallo, Patricia, Lopera, Carlos, Serra, Laia, Cardozo Espinola, Celia, Hernández Meneses, Marta, Rico, Verónica, Bodro, Marta, Morata, Laura, Fernández Pittol, Mariana José, Grafia, Ignacio, Castro Rebollo, Pedro, Mensa Pueyo, Josep, Martínez, José Antonio, Sanjuan, Gemma, Marcos, Ma. Angeles, Soriano Viladomiu, Alex, Garcia Vidal, Carolina, Hospital Clinic of Barcelona COVID-19 Research Group
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2022
País:	España
Institución:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:recercat.cat:2445/198568
Acceso en línea:	https://hdl.handle.net/2445/198568
Access Level:	acceso abierto
Palabra clave:	SARS-CoV-2 COVID-19 Antibiòtics Malalties bacterianes Infeccions per coronavirus Malalts hospitalitzats Antibiotics Bacterial diseases Coronavirus infections Hospital patients

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spelling	Bacterial co-infection at hospital admission in patients with COVID-19Moreno García, EstelaPuerta-Alcalde, PedroLetona Giménez, LauraMeira, FernandaDueñas, GerardChumbita, MarianaGarcía Pouton, NicoleMonzó Gallo, PatriciaLopera, CarlosSerra, LaiaCardozo Espinola, CeliaHernández Meneses, MartaRico, VerónicaBodro, MartaMorata, LauraFernández Pittol, Mariana JoséGrafia, IgnacioCastro Rebollo, PedroMensa Pueyo, JosepMartínez, José AntonioSanjuan, GemmaMarcos, Ma. AngelesSoriano Viladomiu, AlexGarcia Vidal, CarolinaHospital Clinic of Barcelona COVID-19 Research GroupSARS-CoV-2COVID-19AntibiòticsMalalties bacterianesInfeccions per coronavirusMalalts hospitalitzatsSARS-CoV-2COVID-19AntibioticsBacterial diseasesCoronavirus infectionsHospital patientsObjectives: We described the current incidence and risk factors of bacterial co-infection in hospitalized patients with COVID-19. Methods: Observational cohort study was performed at the Hospital Clinic of Barcelona (February 2020-February 2021). All patients with COVID-19 who were admitted for >48 hours with microbiological sample collection and procalcitonin (PCT) determination within the first 48 hours were included. Results: A total of 1125 consecutive adults met inclusion criteria. Co-infections were microbiologically documented in 102 (9.1%) patients. Most frequent microorganisms were Streptococcus pneumoniae (79%), Staphylococcus aureus (6.8%), and Haemophilus influenzae (6.8%). Test positivity was 1% (8/803) for blood cultures, 10.1% (79/780) for pneumococcal urinary antigen test, and 11.4% (15/132) for sputum culture. Patients with PCT higher than 0.2, 0.5, 1, and 2 ng/mL had significantly more co-infections than those with lower levels (p=0.017, p=0.031, p<0.001, and p<0.001, respectively). In multivariate analysis, oxygen saturation ≤94% (OR 2.47, CI 1.57-3.86), ferritin levels <338 ng/mL (OR 2.63, CI 1.69-4.07), and PCT higher than 0.2 ng/mL (OR 1.74, CI 1.11-2.72) were independent risk factors for co-infection at hospital admission owing to COVID-19. Conclusions: Bacterial co-infection in patients hospitalized for COVID-19 is relatively common. However, clinicians could spare antibiotics in patients with PCT values <0.2, especially with high ferritin values and oxygen saturation >94%.Elsevier B.V.2023202320222023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion6 p.application/pdfhttps://hdl.handle.net/2445/198568Articles publicats en revistes (Fonaments Clínics)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1016/j.ijid.2022.03.003International Journal of Infectious Diseases, 2022, vol. 118, p. 197-202https://doi.org/10.1016/j.ijid.2022.03.003cc-by-nc-nd (c) Moreno García, Estela et al., 2022https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1985682026-05-29T05:05:01Z
dc.title.none.fl_str_mv	Bacterial co-infection at hospital admission in patients with COVID-19
title	Bacterial co-infection at hospital admission in patients with COVID-19
spellingShingle	Bacterial co-infection at hospital admission in patients with COVID-19 Moreno García, Estela SARS-CoV-2 COVID-19 Antibiòtics Malalties bacterianes Infeccions per coronavirus Malalts hospitalitzats SARS-CoV-2 COVID-19 Antibiotics Bacterial diseases Coronavirus infections Hospital patients
title_short	Bacterial co-infection at hospital admission in patients with COVID-19
title_full	Bacterial co-infection at hospital admission in patients with COVID-19
title_fullStr	Bacterial co-infection at hospital admission in patients with COVID-19
title_full_unstemmed	Bacterial co-infection at hospital admission in patients with COVID-19
title_sort	Bacterial co-infection at hospital admission in patients with COVID-19
dc.creator.none.fl_str_mv	Moreno García, Estela Puerta-Alcalde, Pedro Letona Giménez, Laura Meira, Fernanda Dueñas, Gerard Chumbita, Mariana García Pouton, Nicole Monzó Gallo, Patricia Lopera, Carlos Serra, Laia Cardozo Espinola, Celia Hernández Meneses, Marta Rico, Verónica Bodro, Marta Morata, Laura Fernández Pittol, Mariana José Grafia, Ignacio Castro Rebollo, Pedro Mensa Pueyo, Josep Martínez, José Antonio Sanjuan, Gemma Marcos, Ma. Angeles Soriano Viladomiu, Alex Garcia Vidal, Carolina Hospital Clinic of Barcelona COVID-19 Research Group
author	Moreno García, Estela
author_facet	Moreno García, Estela Puerta-Alcalde, Pedro Letona Giménez, Laura Meira, Fernanda Dueñas, Gerard Chumbita, Mariana García Pouton, Nicole Monzó Gallo, Patricia Lopera, Carlos Serra, Laia Cardozo Espinola, Celia Hernández Meneses, Marta Rico, Verónica Bodro, Marta Morata, Laura Fernández Pittol, Mariana José Grafia, Ignacio Castro Rebollo, Pedro Mensa Pueyo, Josep Martínez, José Antonio Sanjuan, Gemma Marcos, Ma. Angeles Soriano Viladomiu, Alex Garcia Vidal, Carolina Hospital Clinic of Barcelona COVID-19 Research Group
author_role	author
author2	Puerta-Alcalde, Pedro Letona Giménez, Laura Meira, Fernanda Dueñas, Gerard Chumbita, Mariana García Pouton, Nicole Monzó Gallo, Patricia Lopera, Carlos Serra, Laia Cardozo Espinola, Celia Hernández Meneses, Marta Rico, Verónica Bodro, Marta Morata, Laura Fernández Pittol, Mariana José Grafia, Ignacio Castro Rebollo, Pedro Mensa Pueyo, Josep Martínez, José Antonio Sanjuan, Gemma Marcos, Ma. Angeles Soriano Viladomiu, Alex Garcia Vidal, Carolina Hospital Clinic of Barcelona COVID-19 Research Group
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	SARS-CoV-2 COVID-19 Antibiòtics Malalties bacterianes Infeccions per coronavirus Malalts hospitalitzats SARS-CoV-2 COVID-19 Antibiotics Bacterial diseases Coronavirus infections Hospital patients
topic	SARS-CoV-2 COVID-19 Antibiòtics Malalties bacterianes Infeccions per coronavirus Malalts hospitalitzats SARS-CoV-2 COVID-19 Antibiotics Bacterial diseases Coronavirus infections Hospital patients
description	Objectives: We described the current incidence and risk factors of bacterial co-infection in hospitalized patients with COVID-19. Methods: Observational cohort study was performed at the Hospital Clinic of Barcelona (February 2020-February 2021). All patients with COVID-19 who were admitted for >48 hours with microbiological sample collection and procalcitonin (PCT) determination within the first 48 hours were included. Results: A total of 1125 consecutive adults met inclusion criteria. Co-infections were microbiologically documented in 102 (9.1%) patients. Most frequent microorganisms were Streptococcus pneumoniae (79%), Staphylococcus aureus (6.8%), and Haemophilus influenzae (6.8%). Test positivity was 1% (8/803) for blood cultures, 10.1% (79/780) for pneumococcal urinary antigen test, and 11.4% (15/132) for sputum culture. Patients with PCT higher than 0.2, 0.5, 1, and 2 ng/mL had significantly more co-infections than those with lower levels (p=0.017, p=0.031, p<0.001, and p<0.001, respectively). In multivariate analysis, oxygen saturation ≤94% (OR 2.47, CI 1.57-3.86), ferritin levels <338 ng/mL (OR 2.63, CI 1.69-4.07), and PCT higher than 0.2 ng/mL (OR 1.74, CI 1.11-2.72) were independent risk factors for co-infection at hospital admission owing to COVID-19. Conclusions: Bacterial co-infection in patients hospitalized for COVID-19 is relatively common. However, clinicians could spare antibiotics in patients with PCT values <0.2, especially with high ferritin values and oxygen saturation >94%.
publishDate	2022
dc.date.none.fl_str_mv	2022 2023 2023 2023
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/198568
url	https://hdl.handle.net/2445/198568
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Reproducció del document publicat a: https://doi.org/10.1016/j.ijid.2022.03.003 International Journal of Infectious Diseases, 2022, vol. 118, p. 197-202 https://doi.org/10.1016/j.ijid.2022.03.003
dc.rights.none.fl_str_mv	cc-by-nc-nd (c) Moreno García, Estela et al., 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	cc-by-nc-nd (c) Moreno García, Estela et al., 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	6 p. application/pdf
dc.publisher.none.fl_str_mv	Elsevier B.V.
publisher.none.fl_str_mv	Elsevier B.V.
dc.source.none.fl_str_mv	Articles publicats en revistes (Fonaments Clínics) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Bacterial co-infection at hospital admission in patients with COVID-19

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