Bacterial co-infection at hospital admission in patients with COVID-19

Objectives: We described the current incidence and risk factors of bacterial co-infection in hospitalized patients with COVID-19. Methods: Observational cohort study was performed at the Hospital Clinic of Barcelona (February 2020-February 2021). All patients with COVID-19 who were admitted for &...

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Detalles Bibliográficos
Autores: Moreno García, Estela, Puerta-Alcalde, Pedro, Letona Giménez, Laura, Meira, Fernanda, Dueñas, Gerard, Chumbita, Mariana, García Pouton, Nicole, Monzó Gallo, Patricia, Lopera, Carlos, Serra, Laia, Cardozo Espinola, Celia, Hernández Meneses, Marta, Rico, Verónica, Bodro, Marta, Morata, Laura, Fernández Pittol, Mariana José, Grafia, Ignacio, Castro Rebollo, Pedro, Mensa Pueyo, Josep, Martínez, José Antonio, Sanjuan, Gemma, Marcos, Ma. Angeles, Soriano Viladomiu, Alex, Garcia Vidal, Carolina, Hospital Clinic of Barcelona COVID-19 Research Group
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/198568
Acceso en línea:https://hdl.handle.net/2445/198568
Access Level:acceso abierto
Palabra clave:SARS-CoV-2
COVID-19
Antibiòtics
Malalties bacterianes
Infeccions per coronavirus
Malalts hospitalitzats
Antibiotics
Bacterial diseases
Coronavirus infections
Hospital patients
Descripción
Sumario:Objectives: We described the current incidence and risk factors of bacterial co-infection in hospitalized patients with COVID-19. Methods: Observational cohort study was performed at the Hospital Clinic of Barcelona (February 2020-February 2021). All patients with COVID-19 who were admitted for >48 hours with microbiological sample collection and procalcitonin (PCT) determination within the first 48 hours were included. Results: A total of 1125 consecutive adults met inclusion criteria. Co-infections were microbiologically documented in 102 (9.1%) patients. Most frequent microorganisms were Streptococcus pneumoniae (79%), Staphylococcus aureus (6.8%), and Haemophilus influenzae (6.8%). Test positivity was 1% (8/803) for blood cultures, 10.1% (79/780) for pneumococcal urinary antigen test, and 11.4% (15/132) for sputum culture. Patients with PCT higher than 0.2, 0.5, 1, and 2 ng/mL had significantly more co-infections than those with lower levels (p=0.017, p=0.031, p<0.001, and p<0.001, respectively). In multivariate analysis, oxygen saturation ≤94% (OR 2.47, CI 1.57-3.86), ferritin levels <338 ng/mL (OR 2.63, CI 1.69-4.07), and PCT higher than 0.2 ng/mL (OR 1.74, CI 1.11-2.72) were independent risk factors for co-infection at hospital admission owing to COVID-19. Conclusions: Bacterial co-infection in patients hospitalized for COVID-19 is relatively common. However, clinicians could spare antibiotics in patients with PCT values <0.2, especially with high ferritin values and oxygen saturation >94%.

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