Impact of refrigeration and freezing-thawing of breast milk on in vitro digestibility and liposoluble vitamin bioaccessibility in breast-fed infants

[EN] There is little information about the impact of refrigeration and freezing-thawing on breast milk digestibility under gastrointestinal conditions of healthy infants or those requiring pancreatic enzyme replacement therapy (PERT) such as infants with cystic fibrosis (CF). This study assessed the...

Descripción completa

Detalles Bibliográficos
Autores: Hernández-Olivas, Éver, Asensio-Grau, Andrea, Calvo-Lerma, Joaquim, Heredia Gutiérrez, Ana Belén|||0000-0001-6629-9779, Andrés Grau, Ana María|||0000-0002-6132-3167
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/205268
Acceso en línea:https://riunet.upv.es/handle/10251/205268
Access Level:acceso abierto
Palabra clave:Breast milk
Lipolysis
Proteolysis
Cystic fibrosis
Pancreatic insufficiency
TECNOLOGIA DE ALIMENTOS
id ES_95a4a7c2fac06f36d9e8faf938ea5a3e
oai_identifier_str oai:riunet.upv.es:10251/205268
network_acronym_str ES
network_name_str España
repository_id_str
spelling Impact of refrigeration and freezing-thawing of breast milk on in vitro digestibility and liposoluble vitamin bioaccessibility in breast-fed infantsHernández-Olivas, ÉverAsensio-Grau, AndreaCalvo-Lerma, JoaquimHeredia Gutiérrez, Ana Belén|||0000-0001-6629-9779Andrés Grau, Ana María|||0000-0002-6132-3167Breast milkLipolysisProteolysisCystic fibrosisPancreatic insufficiencyTECNOLOGIA DE ALIMENTOS[EN] There is little information about the impact of refrigeration and freezing-thawing on breast milk digestibility under gastrointestinal conditions of healthy infants or those requiring pancreatic enzyme replacement therapy (PERT) such as infants with cystic fibrosis (CF). This study assessed the impact of refrigeration and freezing-thawing on fat and protein digestibility and liposoluble vitamin bioaccessibility of breast milk. In vitro digestion models mimicking both healthy infant and CF infant conditions were applied. Freezing-thawing significantly increased the fat globule particle size. For CF digestion, this change had a more negative impact when using a freezing-thawing process than when using refrigeration of breast milk, reducing lipolysis (up to 18%), proteolysis (up to 28%), and vitamin A and E bioaccessibility. Under healthy conditions, no significant effects were detected. An adequate pancreatic enzyme replacement therapy (PERT) dose (25 LU/mL of BM) would enable the same level of lipolysis (55%) as in the healthy scenario. In conclusion, breast milk is the only source of energy and nutrients for breast-fed infants, so to prevent the loss of nutrient absorption, those with CF should not be fed with frozen-thawed breast milk.This research was funded by Generalitat Valenciana, Conselleria de Innovacio, Universitats, Ciència i Societat Digital (Enzimapp Project, ref. AICO/2021/015) and by the Spanish Ministry of Health, Health Research Institute Carlos III (mHealthFQ Project, ref. DTS21/00162) The authors also acknowledge Universitat Politècnica de València for the post-doctoral research grant awarded to Andrea Asensio-Grau.ElsevierDepartamento de Tecnología de AlimentosInstituto Universitario de Ingeniería de Alimentos (FoodUPV)Escuela Técnica Superior de Ingeniería Agronómica y del Medio NaturalGeneralitat ValencianaInstituto de Salud Carlos IIIUniversitat Politècnica de ValènciaFUNDACION PARA LA INVESTIGACION DEL HOSPITAL LA FE VALENCIARepositorio Institucional de la Universitat Politècnica de València Riunet20232023-09-29journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://riunet.upv.es/handle/10251/205268reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII) DTS21%2F00162 SISTEMA DE AUTO-GESTION DEL TRATAMIENTO ENZIMATICO EN FIBROSIS QUISTICA CON UNA APP MOVILGeneralitat Valenciana https://doi.org/10.13039/501100003359 AICO%2F2021%2F015open accesshttp://purl.org/coar/access_right/c_abf2Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/2052682026-06-13T07:49:27Z
dc.title.none.fl_str_mv Impact of refrigeration and freezing-thawing of breast milk on in vitro digestibility and liposoluble vitamin bioaccessibility in breast-fed infants
title Impact of refrigeration and freezing-thawing of breast milk on in vitro digestibility and liposoluble vitamin bioaccessibility in breast-fed infants
spellingShingle Impact of refrigeration and freezing-thawing of breast milk on in vitro digestibility and liposoluble vitamin bioaccessibility in breast-fed infants
Hernández-Olivas, Éver
Breast milk
Lipolysis
Proteolysis
Cystic fibrosis
Pancreatic insufficiency
TECNOLOGIA DE ALIMENTOS
title_short Impact of refrigeration and freezing-thawing of breast milk on in vitro digestibility and liposoluble vitamin bioaccessibility in breast-fed infants
title_full Impact of refrigeration and freezing-thawing of breast milk on in vitro digestibility and liposoluble vitamin bioaccessibility in breast-fed infants
title_fullStr Impact of refrigeration and freezing-thawing of breast milk on in vitro digestibility and liposoluble vitamin bioaccessibility in breast-fed infants
title_full_unstemmed Impact of refrigeration and freezing-thawing of breast milk on in vitro digestibility and liposoluble vitamin bioaccessibility in breast-fed infants
title_sort Impact of refrigeration and freezing-thawing of breast milk on in vitro digestibility and liposoluble vitamin bioaccessibility in breast-fed infants
dc.creator.none.fl_str_mv Hernández-Olivas, Éver
Asensio-Grau, Andrea
Calvo-Lerma, Joaquim
Heredia Gutiérrez, Ana Belén|||0000-0001-6629-9779
Andrés Grau, Ana María|||0000-0002-6132-3167
author Hernández-Olivas, Éver
author_facet Hernández-Olivas, Éver
Asensio-Grau, Andrea
Calvo-Lerma, Joaquim
Heredia Gutiérrez, Ana Belén|||0000-0001-6629-9779
Andrés Grau, Ana María|||0000-0002-6132-3167
author_role author
author2 Asensio-Grau, Andrea
Calvo-Lerma, Joaquim
Heredia Gutiérrez, Ana Belén|||0000-0001-6629-9779
Andrés Grau, Ana María|||0000-0002-6132-3167
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Tecnología de Alimentos
Instituto Universitario de Ingeniería de Alimentos (FoodUPV)
Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural
Generalitat Valenciana
Instituto de Salud Carlos III
Universitat Politècnica de València
FUNDACION PARA LA INVESTIGACION DEL HOSPITAL LA FE VALENCIA
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv Breast milk
Lipolysis
Proteolysis
Cystic fibrosis
Pancreatic insufficiency
TECNOLOGIA DE ALIMENTOS
topic Breast milk
Lipolysis
Proteolysis
Cystic fibrosis
Pancreatic insufficiency
TECNOLOGIA DE ALIMENTOS
description [EN] There is little information about the impact of refrigeration and freezing-thawing on breast milk digestibility under gastrointestinal conditions of healthy infants or those requiring pancreatic enzyme replacement therapy (PERT) such as infants with cystic fibrosis (CF). This study assessed the impact of refrigeration and freezing-thawing on fat and protein digestibility and liposoluble vitamin bioaccessibility of breast milk. In vitro digestion models mimicking both healthy infant and CF infant conditions were applied. Freezing-thawing significantly increased the fat globule particle size. For CF digestion, this change had a more negative impact when using a freezing-thawing process than when using refrigeration of breast milk, reducing lipolysis (up to 18%), proteolysis (up to 28%), and vitamin A and E bioaccessibility. Under healthy conditions, no significant effects were detected. An adequate pancreatic enzyme replacement therapy (PERT) dose (25 LU/mL of BM) would enable the same level of lipolysis (55%) as in the healthy scenario. In conclusion, breast milk is the only source of energy and nutrients for breast-fed infants, so to prevent the loss of nutrient absorption, those with CF should not be fed with frozen-thawed breast milk.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-09-29
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/205268
url https://riunet.upv.es/handle/10251/205268
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII) DTS21%2F00162 SISTEMA DE AUTO-GESTION DEL TRATAMIENTO ENZIMATICO EN FIBROSIS QUISTICA CON UNA APP MOVIL
Generalitat Valenciana https://doi.org/10.13039/501100003359 AICO%2F2021%2F015
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento - No comercial - Sin obra derivada (by-nc-nd)
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento - No comercial - Sin obra derivada (by-nc-nd)
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869413838469726208
score 15,812429

Similares en LA Referencia