Differential effects of short-term and long-term ketogenic diet on gene expression in the aging mouse brain

[Background] Aging is associated with multiple neurodegenerative conditions that severely limit quality of life and can shorten lifespan. Studies in rodents indicate that in addition to extending lifespan, the ketogenic diet (KD) improves cognitive function in aged animals, yet long term adherence t...

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Detalles Bibliográficos
Autores: Stratton, Matthew S., López-Domínguez, José Alberto, Canella, Alessandro, Ramsey, Jon J., Cortopassi, Gino A.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/424257
Acceso en línea:http://hdl.handle.net/10261/424257
Access Level:acceso abierto
Palabra clave:Ketogenic diet
Brain aging
Transcriptomics
Target discovery
Descripción
Sumario:[Background] Aging is associated with multiple neurodegenerative conditions that severely limit quality of life and can shorten lifespan. Studies in rodents indicate that in addition to extending lifespan, the ketogenic diet (KD) improves cognitive function in aged animals, yet long term adherence to KD in Humans is poor.

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