Genetic influences on hippocampal subfields: an emerging area of neuroscience research
There is clear evidence that hippocampal subfield volumes have partly distinct genetic determinants associated with specific biological processes. The identification of genetic correlates of hippocampal subfield volumes may help to elucidate the mechanisms of neurologic diseases, as well as aging an...
| Autores: | , , , , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Recursos: | Universitat Pompeu Fabra |
| Repositorio: | Repositorio Digital de la UPF |
| OAI Identifier: | oai:repositori.upf.edu:10230/49046 |
| Acesso em linha: | http://hdl.handle.net/10230/49046 http://dx.doi.org/10.1212/NXG.0000000000000591 |
| Access Level: | acceso abierto |
| Palavra-chave: | All global neurology All Imaging All Genetics |
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Genetic influences on hippocampal subfields: an emerging area of neuroscience researchVilor Tejedor, Natàlia, 1988-Evans, Tavia E.Adams, Hieab H.González de Echávarri, José MariaMolinuevo, José LuisGuigó Serra, RodericGispert, Juan DomingoOperto, GrégoryAll global neurologyAll ImagingAll GeneticsThere is clear evidence that hippocampal subfield volumes have partly distinct genetic determinants associated with specific biological processes. The identification of genetic correlates of hippocampal subfield volumes may help to elucidate the mechanisms of neurologic diseases, as well as aging and neurodegenerative processes. However, despite the emerging interest in this area of research, the current knowledge of the genetic architecture of hippocampal subfields has not yet been consolidated. We aimed to provide a review of the current evidence from genetic studies of hippocampal subfields, highlighting current priorities and upcoming challenges. The limited number of studies investigating the influential genetic effects on hippocampal subfields, a lack of replicated results and longitudinal designs, and modest sample sizes combined with insufficient standardization of protocols are identified as the most pressing challenges in this emerging area of research.Wolters Kluwer (LWW)202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/49046http://dx.doi.org/10.1212/NXG.0000000000000591reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésNeurol Genet. 2021;7(3):e591© 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/490462026-06-12T07:21:37Z |
| dc.title.none.fl_str_mv |
Genetic influences on hippocampal subfields: an emerging area of neuroscience research |
| title |
Genetic influences on hippocampal subfields: an emerging area of neuroscience research |
| spellingShingle |
Genetic influences on hippocampal subfields: an emerging area of neuroscience research Vilor Tejedor, Natàlia, 1988- All global neurology All Imaging All Genetics |
| title_short |
Genetic influences on hippocampal subfields: an emerging area of neuroscience research |
| title_full |
Genetic influences on hippocampal subfields: an emerging area of neuroscience research |
| title_fullStr |
Genetic influences on hippocampal subfields: an emerging area of neuroscience research |
| title_full_unstemmed |
Genetic influences on hippocampal subfields: an emerging area of neuroscience research |
| title_sort |
Genetic influences on hippocampal subfields: an emerging area of neuroscience research |
| dc.creator.none.fl_str_mv |
Vilor Tejedor, Natàlia, 1988- Evans, Tavia E. Adams, Hieab H. González de Echávarri, José Maria Molinuevo, José Luis Guigó Serra, Roderic Gispert, Juan Domingo Operto, Grégory |
| author |
Vilor Tejedor, Natàlia, 1988- |
| author_facet |
Vilor Tejedor, Natàlia, 1988- Evans, Tavia E. Adams, Hieab H. González de Echávarri, José Maria Molinuevo, José Luis Guigó Serra, Roderic Gispert, Juan Domingo Operto, Grégory |
| author_role |
author |
| author2 |
Evans, Tavia E. Adams, Hieab H. González de Echávarri, José Maria Molinuevo, José Luis Guigó Serra, Roderic Gispert, Juan Domingo Operto, Grégory |
| author2_role |
author author author author author author author |
| dc.subject.none.fl_str_mv |
All global neurology All Imaging All Genetics |
| topic |
All global neurology All Imaging All Genetics |
| description |
There is clear evidence that hippocampal subfield volumes have partly distinct genetic determinants associated with specific biological processes. The identification of genetic correlates of hippocampal subfield volumes may help to elucidate the mechanisms of neurologic diseases, as well as aging and neurodegenerative processes. However, despite the emerging interest in this area of research, the current knowledge of the genetic architecture of hippocampal subfields has not yet been consolidated. We aimed to provide a review of the current evidence from genetic studies of hippocampal subfields, highlighting current priorities and upcoming challenges. The limited number of studies investigating the influential genetic effects on hippocampal subfields, a lack of replicated results and longitudinal designs, and modest sample sizes combined with insufficient standardization of protocols are identified as the most pressing challenges in this emerging area of research. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2021 2021 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10230/49046 http://dx.doi.org/10.1212/NXG.0000000000000591 |
| url |
http://hdl.handle.net/10230/49046 http://dx.doi.org/10.1212/NXG.0000000000000591 |
| dc.language.none.fl_str_mv |
Inglés |
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Inglés |
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Neurol Genet. 2021;7(3):e591 |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Wolters Kluwer (LWW) |
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Wolters Kluwer (LWW) |
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reponame:Repositorio Digital de la UPF instname:Universitat Pompeu Fabra |
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Universitat Pompeu Fabra |
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Repositorio Digital de la UPF |
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Repositorio Digital de la UPF |
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15,812429 |