Preoperative identification of patients at high risk of deep venous thrombosis despite prophylaxis in total hip replacement

Clinical and laboratory variables were measured on the day before operation in 111 patients who underwent total hip replacement prophylactically treated with acetylsalicylic acid or heparin-dihydroergotamine. Postoperative deep vein thrombosis (DVT) was detected in 16 patients by ascending venograph...

Descripción completa

Detalles Bibliográficos
Autores: Rocha, E. (Eduardo)|||/items/96d5cf13-d967-4252-8888-36a4956209d6, Alfaro, M.J. (M.J.)|||/items/e15c83b4-dc27-49aa-bb64-289e6b03de66, Páramo-Fernández, J.A. (José Antonio)|||/items/8c56baa6-2a43-4836-b91b-4eed15be3c96, Cañadell, J.M. (J. M.)|||/items/2becc2e2-213a-4695-91cf-07a6340692c8
Tipo de recurso: artículo
Fecha de publicación:1988
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/22522
Acceso en línea:https://hdl.handle.net/10171/22522
Access Level:acceso abierto
Palabra clave:Predictive index
Deep vein thrombosis
Total hip replacement
Surgery
id ES_93038f0bbf078d95e0fc4b4d5b686b8b
oai_identifier_str oai:dadun.unav.edu:10171/22522
network_acronym_str ES
network_name_str España
repository_id_str
spelling Preoperative identification of patients at high risk of deep venous thrombosis despite prophylaxis in total hip replacementRocha, E. (Eduardo)|||/items/96d5cf13-d967-4252-8888-36a4956209d6Alfaro, M.J. (M.J.)|||/items/e15c83b4-dc27-49aa-bb64-289e6b03de66Páramo-Fernández, J.A. (José Antonio)|||/items/8c56baa6-2a43-4836-b91b-4eed15be3c96Cañadell, J.M. (J. M.)|||/items/2becc2e2-213a-4695-91cf-07a6340692c8Predictive indexDeep vein thrombosisTotal hip replacementSurgeryClinical and laboratory variables were measured on the day before operation in 111 patients who underwent total hip replacement prophylactically treated with acetylsalicylic acid or heparin-dihydroergotamine. Postoperative deep vein thrombosis (DVT) was detected in 16 patients by ascending venography. Stepwise logistic discriminant analysis was used to identify DVT predicting factors. Three such factors, fibrinogen degradation products (FDP), plasminogen activator inhibitor (PA-inhibitor) and tissue type plasminogen activator (t-PA), were found to be significantly associated with DVT and were used to construct a predictive index. The predictive index, I = -2.09 + 0.46 (FDP) + 1.39 (PA-inhibitor) -0.24 (t-PA), was 100% sensitive and 95% specific in the prediction of DVT. This index would allow for identification of those patients in whom routine prophylaxis would be sufficient and for selecting those in whom more effective prophylactic regimens would be necessary.SchattauerDadun. Depósito Académico Digital Universidad de Navarra20122012-06-0819881988-01-0119881988-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/22522reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/225222026-06-21T12:47:57Z
dc.title.none.fl_str_mv Preoperative identification of patients at high risk of deep venous thrombosis despite prophylaxis in total hip replacement
title Preoperative identification of patients at high risk of deep venous thrombosis despite prophylaxis in total hip replacement
spellingShingle Preoperative identification of patients at high risk of deep venous thrombosis despite prophylaxis in total hip replacement
Rocha, E. (Eduardo)|||/items/96d5cf13-d967-4252-8888-36a4956209d6
Predictive index
Deep vein thrombosis
Total hip replacement
Surgery
title_short Preoperative identification of patients at high risk of deep venous thrombosis despite prophylaxis in total hip replacement
title_full Preoperative identification of patients at high risk of deep venous thrombosis despite prophylaxis in total hip replacement
title_fullStr Preoperative identification of patients at high risk of deep venous thrombosis despite prophylaxis in total hip replacement
title_full_unstemmed Preoperative identification of patients at high risk of deep venous thrombosis despite prophylaxis in total hip replacement
title_sort Preoperative identification of patients at high risk of deep venous thrombosis despite prophylaxis in total hip replacement
dc.creator.none.fl_str_mv Rocha, E. (Eduardo)|||/items/96d5cf13-d967-4252-8888-36a4956209d6
Alfaro, M.J. (M.J.)|||/items/e15c83b4-dc27-49aa-bb64-289e6b03de66
Páramo-Fernández, J.A. (José Antonio)|||/items/8c56baa6-2a43-4836-b91b-4eed15be3c96
Cañadell, J.M. (J. M.)|||/items/2becc2e2-213a-4695-91cf-07a6340692c8
author Rocha, E. (Eduardo)|||/items/96d5cf13-d967-4252-8888-36a4956209d6
author_facet Rocha, E. (Eduardo)|||/items/96d5cf13-d967-4252-8888-36a4956209d6
Alfaro, M.J. (M.J.)|||/items/e15c83b4-dc27-49aa-bb64-289e6b03de66
Páramo-Fernández, J.A. (José Antonio)|||/items/8c56baa6-2a43-4836-b91b-4eed15be3c96
Cañadell, J.M. (J. M.)|||/items/2becc2e2-213a-4695-91cf-07a6340692c8
author_role author
author2 Alfaro, M.J. (M.J.)|||/items/e15c83b4-dc27-49aa-bb64-289e6b03de66
Páramo-Fernández, J.A. (José Antonio)|||/items/8c56baa6-2a43-4836-b91b-4eed15be3c96
Cañadell, J.M. (J. M.)|||/items/2becc2e2-213a-4695-91cf-07a6340692c8
author2_role author
author
author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv Predictive index
Deep vein thrombosis
Total hip replacement
Surgery
topic Predictive index
Deep vein thrombosis
Total hip replacement
Surgery
description Clinical and laboratory variables were measured on the day before operation in 111 patients who underwent total hip replacement prophylactically treated with acetylsalicylic acid or heparin-dihydroergotamine. Postoperative deep vein thrombosis (DVT) was detected in 16 patients by ascending venography. Stepwise logistic discriminant analysis was used to identify DVT predicting factors. Three such factors, fibrinogen degradation products (FDP), plasminogen activator inhibitor (PA-inhibitor) and tissue type plasminogen activator (t-PA), were found to be significantly associated with DVT and were used to construct a predictive index. The predictive index, I = -2.09 + 0.46 (FDP) + 1.39 (PA-inhibitor) -0.24 (t-PA), was 100% sensitive and 95% specific in the prediction of DVT. This index would allow for identification of those patients in whom routine prophylaxis would be sufficient and for selecting those in whom more effective prophylactic regimens would be necessary.
publishDate 1988
dc.date.none.fl_str_mv 1988
1988-01-01
1988
1988-01-01
2012
2012-06-08
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/22522
url https://hdl.handle.net/10171/22522
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Schattauer
publisher.none.fl_str_mv Schattauer
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869413531849326592
score 15.300719

Similares en LA Referencia