Repurposing chemotherapy-induced peripheral neuropathy grading

Background and purpose: Chemotherapy-induced peripheral neuropathy (CIPN) is perceived differently by patients and physicians, complicating its assessment. Current recommendations advocate combining clinical and patient-reported outcomes measures, but this approach can be challenging in patient care...

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Autores: Velasco, Roser, Argyriou, Andreas A., R. Cornblath, David, Bruna Escuer, Pere|||0000-0002-7411-1278, Alberti, Paola, Rossi, Emanuela, S.J. Merkies, Ingemar, Psimaras, Dimitri, Briani, Chiara, I. Lalisang, Roy, Schenone, Angelo, Guido, Cavaletti, Bruna, Jordi
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/423215
Acceso en línea:https://hdl.handle.net/2117/423215
https://dx.doi.org/10.1111/ene.16457
Access Level:acceso abierto
Palabra clave:Chemotherapy
Chemotherapy-induced peripheral neuropathy
Neurotoxicity
Patient-reported outcome measure
Àrees temàtiques de la UPC::Física
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spelling Repurposing chemotherapy-induced peripheral neuropathy gradingVelasco, RoserArgyriou, Andreas A.R. Cornblath, DavidBruna Escuer, Pere|||0000-0002-7411-1278Alberti, PaolaRossi, EmanuelaS.J. Merkies, IngemarPsimaras, DimitriBriani, ChiaraI. Lalisang, RoySchenone, AngeloGuido, CavalettiBruna, JordiChemotherapyChemotherapy-induced peripheral neuropathyNeurotoxicityPatient-reported outcome measureÀrees temàtiques de la UPC::FísicaBackground and purpose: Chemotherapy-induced peripheral neuropathy (CIPN) is perceived differently by patients and physicians, complicating its assessment. Current recommendations advocate combining clinical and patient-reported outcomes measures, but this approach can be challenging in patient care. This multicenter European study aims to bridge the gap between patients' perceptions and neurological impairments by aligning both perspectives to improve treatment decision-making. Methods: Data were pooled from two prospective studies of subjects (n = 372) with established CIPN. Patient and physician views regarding CIPN were assessed using the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE), Total Neuropathy Scale-clinical version (TNSc) items, and the disease-specific quality of life - Chemotherapy-Induced Peripheral Neuropathy questionnaire (QLQ-CIPN20) from the European Organization for Research and Treatment of Cancer (EORTC). To identify inherent neurotoxic severity patterns, we employed hierarchical cluster analysis optimized with k-means clustering and internally validated by discriminant functional analysis. Results: Both NCI-CTCAE and TNSc demonstrated a significant difference in the distribution of severity grades in relation to QLQ-CIPN20 scores. However, a proportion of subjects with different neurotoxic severity grades exhibited overlapping QLQ-CIPN20 scores. We identified three distinct clusters classifying subjects as having severely impaired, intermediately impaired, and mildly impaired CIPN based on TNSc and QLQ-CIPN20 scores. No differences in demographics, cancer type distribution, or class of drug received were observed. Conclusions: Our results confirm the heterogeneity in CIPN perception between patients and physicians and identify three well-differentiated subgroups of patients delineated by degree of CIPN impairment based on scores derived from TNSc and QLQ-CIPN20. A more refined assessment of CIPN could potentially be achieved using the calculator tool derived from the cluster equations in this study. This tool, which facilitates individual patient classification, requires prospective validation.Peer Reviewed20242024-12-0220252025-02-03journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/423215https://dx.doi.org/10.1111/ene.16457reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/4232152026-05-27T15:37:01Z
dc.title.none.fl_str_mv Repurposing chemotherapy-induced peripheral neuropathy grading
title Repurposing chemotherapy-induced peripheral neuropathy grading
spellingShingle Repurposing chemotherapy-induced peripheral neuropathy grading
Velasco, Roser
Chemotherapy
Chemotherapy-induced peripheral neuropathy
Neurotoxicity
Patient-reported outcome measure
Àrees temàtiques de la UPC::Física
title_short Repurposing chemotherapy-induced peripheral neuropathy grading
title_full Repurposing chemotherapy-induced peripheral neuropathy grading
title_fullStr Repurposing chemotherapy-induced peripheral neuropathy grading
title_full_unstemmed Repurposing chemotherapy-induced peripheral neuropathy grading
title_sort Repurposing chemotherapy-induced peripheral neuropathy grading
dc.creator.none.fl_str_mv Velasco, Roser
Argyriou, Andreas A.
R. Cornblath, David
Bruna Escuer, Pere|||0000-0002-7411-1278
Alberti, Paola
Rossi, Emanuela
S.J. Merkies, Ingemar
Psimaras, Dimitri
Briani, Chiara
I. Lalisang, Roy
Schenone, Angelo
Guido, Cavaletti
Bruna, Jordi
author Velasco, Roser
author_facet Velasco, Roser
Argyriou, Andreas A.
R. Cornblath, David
Bruna Escuer, Pere|||0000-0002-7411-1278
Alberti, Paola
Rossi, Emanuela
S.J. Merkies, Ingemar
Psimaras, Dimitri
Briani, Chiara
I. Lalisang, Roy
Schenone, Angelo
Guido, Cavaletti
Bruna, Jordi
author_role author
author2 Argyriou, Andreas A.
R. Cornblath, David
Bruna Escuer, Pere|||0000-0002-7411-1278
Alberti, Paola
Rossi, Emanuela
S.J. Merkies, Ingemar
Psimaras, Dimitri
Briani, Chiara
I. Lalisang, Roy
Schenone, Angelo
Guido, Cavaletti
Bruna, Jordi
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Chemotherapy
Chemotherapy-induced peripheral neuropathy
Neurotoxicity
Patient-reported outcome measure
Àrees temàtiques de la UPC::Física
topic Chemotherapy
Chemotherapy-induced peripheral neuropathy
Neurotoxicity
Patient-reported outcome measure
Àrees temàtiques de la UPC::Física
description Background and purpose: Chemotherapy-induced peripheral neuropathy (CIPN) is perceived differently by patients and physicians, complicating its assessment. Current recommendations advocate combining clinical and patient-reported outcomes measures, but this approach can be challenging in patient care. This multicenter European study aims to bridge the gap between patients' perceptions and neurological impairments by aligning both perspectives to improve treatment decision-making. Methods: Data were pooled from two prospective studies of subjects (n = 372) with established CIPN. Patient and physician views regarding CIPN were assessed using the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE), Total Neuropathy Scale-clinical version (TNSc) items, and the disease-specific quality of life - Chemotherapy-Induced Peripheral Neuropathy questionnaire (QLQ-CIPN20) from the European Organization for Research and Treatment of Cancer (EORTC). To identify inherent neurotoxic severity patterns, we employed hierarchical cluster analysis optimized with k-means clustering and internally validated by discriminant functional analysis. Results: Both NCI-CTCAE and TNSc demonstrated a significant difference in the distribution of severity grades in relation to QLQ-CIPN20 scores. However, a proportion of subjects with different neurotoxic severity grades exhibited overlapping QLQ-CIPN20 scores. We identified three distinct clusters classifying subjects as having severely impaired, intermediately impaired, and mildly impaired CIPN based on TNSc and QLQ-CIPN20 scores. No differences in demographics, cancer type distribution, or class of drug received were observed. Conclusions: Our results confirm the heterogeneity in CIPN perception between patients and physicians and identify three well-differentiated subgroups of patients delineated by degree of CIPN impairment based on scores derived from TNSc and QLQ-CIPN20. A more refined assessment of CIPN could potentially be achieved using the calculator tool derived from the cluster equations in this study. This tool, which facilitates individual patient classification, requires prospective validation.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-12-02
2025
2025-02-03
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/423215
https://dx.doi.org/10.1111/ene.16457
url https://hdl.handle.net/2117/423215
https://dx.doi.org/10.1111/ene.16457
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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