Parieto-motor Cortical Dysfunction in Primary Cervical Dystonia

Background: Dystonia is considered as a motor network disorder involving the dysfunction of the posterior parietal cortex, a region involved in preparing and executing reaching movements. Objective/hypothesis: We used transcranial magnetic stimulation to test the hypothesis that cervical dystonic pa...

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Autores: Porcacchia, Paolo, Palomar, Francisco J., Cáceres-Redondo, María Teresa, Huertas Fernández, Ismael, Martín Rodríguez, Juan Francisco, Carrillo, Fátima, Koch, Giacomo, Mir Rivera, Pablo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/107977
Acceso en línea:https://hdl.handle.net/11441/107977
https://doi.org/10.1016/j.brs.2014.06.007
Access Level:acceso abierto
Palabra clave:Dystonia
Hypokinesia
Parietal lobe
Transcranial magnetic stimulation
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spelling Parieto-motor Cortical Dysfunction in Primary Cervical DystoniaPorcacchia, PaoloPalomar, Francisco J.Cáceres-Redondo, María TeresaHuertas Fernández, IsmaelMartín Rodríguez, Juan FranciscoCarrillo, FátimaKoch, GiacomoMir Rivera, PabloDystoniaHypokinesiaParietal lobeTranscranial magnetic stimulationBackground: Dystonia is considered as a motor network disorder involving the dysfunction of the posterior parietal cortex, a region involved in preparing and executing reaching movements. Objective/hypothesis: We used transcranial magnetic stimulation to test the hypothesis that cervical dystonic patients may have a disrupted parieto-motor connectivity. Methods: We enrolled 14 patients with primary cervical dystonia and 14 controls. A paired-pulse transcranial magnetic stimulation protocol was applied over the right posterior parietal cortex and the right primary motor area. Changes in the amplitudes of motor evoked potential were analyzed as an index of parieto-motor effective connectivity. Patients and healthy subjects were also evaluated with a reaching task. Reaction and movement times were measured. Results: In healthy subjects, but not in dystonic patients, there was a facilitation of motor evoked potential amplitudes when the conditioning parietal stimulus preceded the test stimulus applied over the primary motor area by 4 ms. Reaction and movement times were significantly slower in patients than in controls. In dystonic patients, the relative strength of parieto-motor connectivity correlated with movement times. Conclusions: Parieto-motor cortical connectivity is impaired in cervical dystonic patients. This neurophysiological trait is associated with slower reaching movements.ElsevierMedicina2014info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/107977https://doi.org/10.1016/j.brs.2014.06.007reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésBrain Stimulation, 7 (5), 650-657.t http:// dx.doi.org/10.1016/j.brs.2014.06.007info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1079772026-06-17T12:51:07Z
dc.title.none.fl_str_mv Parieto-motor Cortical Dysfunction in Primary Cervical Dystonia
title Parieto-motor Cortical Dysfunction in Primary Cervical Dystonia
spellingShingle Parieto-motor Cortical Dysfunction in Primary Cervical Dystonia
Porcacchia, Paolo
Dystonia
Hypokinesia
Parietal lobe
Transcranial magnetic stimulation
title_short Parieto-motor Cortical Dysfunction in Primary Cervical Dystonia
title_full Parieto-motor Cortical Dysfunction in Primary Cervical Dystonia
title_fullStr Parieto-motor Cortical Dysfunction in Primary Cervical Dystonia
title_full_unstemmed Parieto-motor Cortical Dysfunction in Primary Cervical Dystonia
title_sort Parieto-motor Cortical Dysfunction in Primary Cervical Dystonia
dc.creator.none.fl_str_mv Porcacchia, Paolo
Palomar, Francisco J.
Cáceres-Redondo, María Teresa
Huertas Fernández, Ismael
Martín Rodríguez, Juan Francisco
Carrillo, Fátima
Koch, Giacomo
Mir Rivera, Pablo
author Porcacchia, Paolo
author_facet Porcacchia, Paolo
Palomar, Francisco J.
Cáceres-Redondo, María Teresa
Huertas Fernández, Ismael
Martín Rodríguez, Juan Francisco
Carrillo, Fátima
Koch, Giacomo
Mir Rivera, Pablo
author_role author
author2 Palomar, Francisco J.
Cáceres-Redondo, María Teresa
Huertas Fernández, Ismael
Martín Rodríguez, Juan Francisco
Carrillo, Fátima
Koch, Giacomo
Mir Rivera, Pablo
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Medicina
dc.subject.none.fl_str_mv Dystonia
Hypokinesia
Parietal lobe
Transcranial magnetic stimulation
topic Dystonia
Hypokinesia
Parietal lobe
Transcranial magnetic stimulation
description Background: Dystonia is considered as a motor network disorder involving the dysfunction of the posterior parietal cortex, a region involved in preparing and executing reaching movements. Objective/hypothesis: We used transcranial magnetic stimulation to test the hypothesis that cervical dystonic patients may have a disrupted parieto-motor connectivity. Methods: We enrolled 14 patients with primary cervical dystonia and 14 controls. A paired-pulse transcranial magnetic stimulation protocol was applied over the right posterior parietal cortex and the right primary motor area. Changes in the amplitudes of motor evoked potential were analyzed as an index of parieto-motor effective connectivity. Patients and healthy subjects were also evaluated with a reaching task. Reaction and movement times were measured. Results: In healthy subjects, but not in dystonic patients, there was a facilitation of motor evoked potential amplitudes when the conditioning parietal stimulus preceded the test stimulus applied over the primary motor area by 4 ms. Reaction and movement times were significantly slower in patients than in controls. In dystonic patients, the relative strength of parieto-motor connectivity correlated with movement times. Conclusions: Parieto-motor cortical connectivity is impaired in cervical dystonic patients. This neurophysiological trait is associated with slower reaching movements.
publishDate 2014
dc.date.none.fl_str_mv 2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/107977
https://doi.org/10.1016/j.brs.2014.06.007
url https://hdl.handle.net/11441/107977
https://doi.org/10.1016/j.brs.2014.06.007
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Brain Stimulation, 7 (5), 650-657.
t http:// dx.doi.org/10.1016/j.brs.2014.06.007
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
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