Efficacy of Deep Brain Stimulation for the Treatment of Monogenic Dystonia Symptoms: A Systematic Review

[Background] Deep brain stimulation (DBS) is an essential treatment option for disabling segmental or generalized dystonia. An underlying monogenic etiology is increasingly recognized as an important predictor of DBS outcomes. Moreover, the genetic background of dystonia is continuously expanding, p...

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Detalles Bibliográficos
Autores: Indelicato, Elisabetta, Carmona-Hidalgo, Beatriz, Quintero, Javier, Ortigoza-Escobar, Juan Darío, Koy, Anne, Salamon, András, Tacik, Pawel, Muñoz-Delgado, Laura, Giannini, Giulia, Reich, Martin, Albanese, Alberto, Bäumer, Tobias, Grandas, Francisco, Jech, Robert, Leonardos, Athanasios, Mir, Pablo, Pérez-Dueñas, Belén, Pérez-Sánchez, Javier Ricardo, Valldeoriola, Francesc, Zanni, Ginevra, Vidailhet, Marie, Rodríguez-López, Rocío, Blasco-Amaro, Juan Antonio, Reinhard, Carola, Boesch, Sylvia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2026
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/420311
Acceso en línea:http://hdl.handle.net/10261/420311
https://api.elsevier.com/content/abstract/scopus_id/105027705369
Access Level:acceso abierto
Palabra clave:Deep brain stimulation
Dystonia
Dystonia genes
Genetic testing
Systematic review
Descripción
Sumario:[Background] Deep brain stimulation (DBS) is an essential treatment option for disabling segmental or generalized dystonia. An underlying monogenic etiology is increasingly recognized as an important predictor of DBS outcomes. Moreover, the genetic background of dystonia is continuously expanding, posing new challenges in the tailored counseling of patients regarding advanced therapies.

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