Examining mixotrophic fermentation in fed‐batch mode for C1‐gas valorization

Producción Científica

Detalles Bibliográficos
Autores: Fernández Delgado, Marina, Plaza Lazaro, Pedro Enrique, García Cubero, María Teresa, Lucas Yagüe, Susana, Coca Sanz, Mónica, López Linares, Juan Carlos
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Universidad de Valladolid
Repositorio:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/76272
Acceso en línea:https://doi.org/10.1002/jctb.7874
https://uvadoc.uva.es/handle/10324/76272
Access Level:acceso abierto
Palabra clave:Mixotrophic fermentation
C1-gases
Biotecnología
Autotrophic fermentation
Clostridia spp
fructose
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spelling Examining mixotrophic fermentation in fed‐batch mode for C1‐gas valorizationFernández Delgado, MarinaPlaza Lazaro, Pedro EnriqueGarcía Cubero, María TeresaLucas Yagüe, SusanaCoca Sanz, MónicaLópez Linares, Juan CarlosMixotrophic fermentationC1-gasesBiotecnologíaAutotrophic fermentationC1-gasesClostridia sppfructoseMixotrophic fermentationProducción CientíficaBACKGROUND: C1-gases like CO and CO2, significant contributors to climate change, offer the potential for sustainable bioconversion into valuable products. The study explored mixotrophic fermentation using C1-gases in fed-batch mode to improve the production of target compounds, focusing on Clostridium aceticum and Clostridium carboxidivorans. It aimed to overcome the limitations of conventional gas fermentation (autotrophic fermentation and without fed-batch mode) and assess the potential of mixotrophic substrates for enhancing yields. RESULTS: Results showed that mixotrophic fermentation with fructose as a co-substrate led to higher microbial growth in C. aceticum, increasing acetic acid (1200 versus 600 mg L−1) and ethanol (600 versus 0 mg L−1) production, compared to autotrophic fermentation. For C. carboxidivorans, constant CO consumption occurred in autotrophic and mixotrophic fermentation. Mixotrophic fermentation with fructose and C1-gases by C. carboxidivorans significantly boosted microbial growth and metabolic activity, increasing butanol (1600 versus 0 mg L−1) and butyric acid (2400 versus 1800 mg L−1) production, compared to autotrophic fermentation. CONCLUSIONS: The study highlights mixotrophic fermentation's potential to enhance C1-gas valorization. It provides insights into microbial behavior under varied substrate conditions, contributing to sustainable biomanufacturing practices for biofuel and high-value bioproducts. © 2025 Society of Chemical Industry (SCI).Este trabajo forma parte del proyecto de investigación: Ministerio de Ciencia e Innovación (Grant number(s): TED2021-129826A-I00/AEI/10.13039/501100011033); Consejería de Educación, Junta de Castilla y León (Grant number(s): UIC 320); Universidad de Valladolid (Grant number(s): UVa postdoctoral)Open access funding provided by FEDER European Funds and the Junta De Castilla y León under the Research and Innovation Strategy for Smart Specialization (RIS3) of Castilla y León 2021-2027.John Wiley & Sons2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.1002/jctb.7874https://uvadoc.uva.es/handle/10324/76272reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidIngléshttps://scijournals.onlinelibrary.wiley.com/doi/epdf/10.1002/jctb.7874info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:uvadoc.uva.es:10324/762722026-06-13T12:44:47Z
dc.title.none.fl_str_mv Examining mixotrophic fermentation in fed‐batch mode for C1‐gas valorization
title Examining mixotrophic fermentation in fed‐batch mode for C1‐gas valorization
spellingShingle Examining mixotrophic fermentation in fed‐batch mode for C1‐gas valorization
Fernández Delgado, Marina
Mixotrophic fermentation
C1-gases
Biotecnología
Autotrophic fermentation
C1-gases
Clostridia spp
fructose
Mixotrophic fermentation
title_short Examining mixotrophic fermentation in fed‐batch mode for C1‐gas valorization
title_full Examining mixotrophic fermentation in fed‐batch mode for C1‐gas valorization
title_fullStr Examining mixotrophic fermentation in fed‐batch mode for C1‐gas valorization
title_full_unstemmed Examining mixotrophic fermentation in fed‐batch mode for C1‐gas valorization
title_sort Examining mixotrophic fermentation in fed‐batch mode for C1‐gas valorization
dc.creator.none.fl_str_mv Fernández Delgado, Marina
Plaza Lazaro, Pedro Enrique
García Cubero, María Teresa
Lucas Yagüe, Susana
Coca Sanz, Mónica
López Linares, Juan Carlos
author Fernández Delgado, Marina
author_facet Fernández Delgado, Marina
Plaza Lazaro, Pedro Enrique
García Cubero, María Teresa
Lucas Yagüe, Susana
Coca Sanz, Mónica
López Linares, Juan Carlos
author_role author
author2 Plaza Lazaro, Pedro Enrique
García Cubero, María Teresa
Lucas Yagüe, Susana
Coca Sanz, Mónica
López Linares, Juan Carlos
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Mixotrophic fermentation
C1-gases
Biotecnología
Autotrophic fermentation
C1-gases
Clostridia spp
fructose
Mixotrophic fermentation
topic Mixotrophic fermentation
C1-gases
Biotecnología
Autotrophic fermentation
C1-gases
Clostridia spp
fructose
Mixotrophic fermentation
description Producción Científica
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1002/jctb.7874
https://uvadoc.uva.es/handle/10324/76272
url https://doi.org/10.1002/jctb.7874
https://uvadoc.uva.es/handle/10324/76272
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://scijournals.onlinelibrary.wiley.com/doi/epdf/10.1002/jctb.7874
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
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