Nucleoside-based supramolecular hydrogels: from synthesis and structural properties to biomedical and tissue engineering applications

Supramolecular hydrogels are of great interest in tissue scaffolding, diagnostics, and drug delivery due to their biocompatibility and stimuli-responsive properties. In particular, nucleosides are promising candidates as building blocks due to their manifold noncovalent interactions and ease of chem...

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Authors: Godoy Gallardo, Maria|||0000-0002-7232-3998, Merino Gómez, Maria, Matiz, Luisamaria C., Mateos Timoneda, Miguel Ángel|||0000-0001-7657-1414, Gil Mur, Francisco Javier|||0000-0002-6824-1412, Pérez Antoñanzas, Román
Format: article
Publication Date:2023
Country:España
Institution:Universitat Politècnica de Catalunya (UPC)
Repository:UPCommons. Portal del coneixement obert de la UPC
Language:English
OAI Identifier:oai:upcommons.upc.edu:2117/422950
Online Access:https://hdl.handle.net/2117/422950
https://dx.doi.org/10.1021/acsbiomaterials.2c01051
Access Level:Open access
Keyword:Nucleoside-based hydrogels
Guanosine and derivatives
Supramolecular hydrogel
Self-assembly
Stability improvement
Enhancement of mechanical properties
Àrees temàtiques de la UPC::Enginyeria química
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spelling Nucleoside-based supramolecular hydrogels: from synthesis and structural properties to biomedical and tissue engineering applicationsGodoy Gallardo, Maria|||0000-0002-7232-3998Merino Gómez, MariaMatiz, Luisamaria C.Mateos Timoneda, Miguel Ángel|||0000-0001-7657-1414Gil Mur, Francisco Javier|||0000-0002-6824-1412Pérez Antoñanzas, RománNucleoside-based hydrogelsGuanosine and derivativesSupramolecular hydrogelSelf-assemblyStability improvementEnhancement of mechanical propertiesÀrees temàtiques de la UPC::Enginyeria químicaSupramolecular hydrogels are of great interest in tissue scaffolding, diagnostics, and drug delivery due to their biocompatibility and stimuli-responsive properties. In particular, nucleosides are promising candidates as building blocks due to their manifold noncovalent interactions and ease of chemical modification. Significant progress in the field has been made over recent years to allow the use of nucleoside-based supramolecular hydrogels in the biomedical field, namely drug delivery and 3D bioprinting. For example, their long-term stability, printability, functionality, and bioactivity have been greatly improved by employing more than one gelator, incorporating different cations, including silver for antibacterial activity, or using additives such as boric acid or even biomolecules. This now permits their use as bioinks for 3D printing to produce cell-laden scaffolds with specified geometries and pore sizes as well as a homogeneous distribution of living cells and bioactive molecules. We have summarized the latest advances in nucleoside-based supramolecular hydrogels. Additionally, we discuss their synthesis, structural properties, and potential applications in tissue engineering and provide an outlook and future perspective on ongoing developments in the field.Peer ReviewedAmerican Chemical Society (ACS)20232023-01-0920252025-01-28journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/422950https://dx.doi.org/10.1021/acsbiomaterials.2c01051reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/4229502026-05-27T15:37:01Z
dc.title.none.fl_str_mv Nucleoside-based supramolecular hydrogels: from synthesis and structural properties to biomedical and tissue engineering applications
title Nucleoside-based supramolecular hydrogels: from synthesis and structural properties to biomedical and tissue engineering applications
spellingShingle Nucleoside-based supramolecular hydrogels: from synthesis and structural properties to biomedical and tissue engineering applications
Godoy Gallardo, Maria|||0000-0002-7232-3998
Nucleoside-based hydrogels
Guanosine and derivatives
Supramolecular hydrogel
Self-assembly
Stability improvement
Enhancement of mechanical properties
Àrees temàtiques de la UPC::Enginyeria química
title_short Nucleoside-based supramolecular hydrogels: from synthesis and structural properties to biomedical and tissue engineering applications
title_full Nucleoside-based supramolecular hydrogels: from synthesis and structural properties to biomedical and tissue engineering applications
title_fullStr Nucleoside-based supramolecular hydrogels: from synthesis and structural properties to biomedical and tissue engineering applications
title_full_unstemmed Nucleoside-based supramolecular hydrogels: from synthesis and structural properties to biomedical and tissue engineering applications
title_sort Nucleoside-based supramolecular hydrogels: from synthesis and structural properties to biomedical and tissue engineering applications
dc.creator.none.fl_str_mv Godoy Gallardo, Maria|||0000-0002-7232-3998
Merino Gómez, Maria
Matiz, Luisamaria C.
Mateos Timoneda, Miguel Ángel|||0000-0001-7657-1414
Gil Mur, Francisco Javier|||0000-0002-6824-1412
Pérez Antoñanzas, Román
author Godoy Gallardo, Maria|||0000-0002-7232-3998
author_facet Godoy Gallardo, Maria|||0000-0002-7232-3998
Merino Gómez, Maria
Matiz, Luisamaria C.
Mateos Timoneda, Miguel Ángel|||0000-0001-7657-1414
Gil Mur, Francisco Javier|||0000-0002-6824-1412
Pérez Antoñanzas, Román
author_role author
author2 Merino Gómez, Maria
Matiz, Luisamaria C.
Mateos Timoneda, Miguel Ángel|||0000-0001-7657-1414
Gil Mur, Francisco Javier|||0000-0002-6824-1412
Pérez Antoñanzas, Román
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Nucleoside-based hydrogels
Guanosine and derivatives
Supramolecular hydrogel
Self-assembly
Stability improvement
Enhancement of mechanical properties
Àrees temàtiques de la UPC::Enginyeria química
topic Nucleoside-based hydrogels
Guanosine and derivatives
Supramolecular hydrogel
Self-assembly
Stability improvement
Enhancement of mechanical properties
Àrees temàtiques de la UPC::Enginyeria química
description Supramolecular hydrogels are of great interest in tissue scaffolding, diagnostics, and drug delivery due to their biocompatibility and stimuli-responsive properties. In particular, nucleosides are promising candidates as building blocks due to their manifold noncovalent interactions and ease of chemical modification. Significant progress in the field has been made over recent years to allow the use of nucleoside-based supramolecular hydrogels in the biomedical field, namely drug delivery and 3D bioprinting. For example, their long-term stability, printability, functionality, and bioactivity have been greatly improved by employing more than one gelator, incorporating different cations, including silver for antibacterial activity, or using additives such as boric acid or even biomolecules. This now permits their use as bioinks for 3D printing to produce cell-laden scaffolds with specified geometries and pore sizes as well as a homogeneous distribution of living cells and bioactive molecules. We have summarized the latest advances in nucleoside-based supramolecular hydrogels. Additionally, we discuss their synthesis, structural properties, and potential applications in tissue engineering and provide an outlook and future perspective on ongoing developments in the field.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-01-09
2025
2025-01-28
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/422950
https://dx.doi.org/10.1021/acsbiomaterials.2c01051
url https://hdl.handle.net/2117/422950
https://dx.doi.org/10.1021/acsbiomaterials.2c01051
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Chemical Society (ACS)
publisher.none.fl_str_mv American Chemical Society (ACS)
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869413430515990528
score 15,812429

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