The maternal gut microbiome in pregnancy: implications for the developing immune system

The gut microbiome has important roles in host metabolism and immunity, and microbial dysbiosis affects human physiology and health. Maternal immunity and microbial metabolites during pregnancy, microbial transfer during birth, and transfer of immune factors, microorganisms and metabolites via breas...

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Detalles Bibliográficos
Autores: Koren, Omry, Konnikova, Liza, Brodin, Petter, Mysorekar, Indira U., Collado, María Carmen
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/341845
Acceso en línea:http://hdl.handle.net/10261/341845
https://api.elsevier.com/content/abstract/scopus_id/85179956602
Access Level:acceso abierto
Palabra clave:Gut
Microbiome
Immunity
Pregnancy
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spelling The maternal gut microbiome in pregnancy: implications for the developing immune systemKoren, OmryKonnikova, LizaBrodin, PetterMysorekar, Indira U.Collado, María CarmenGutMicrobiomeImmunityPregnancyThe gut microbiome has important roles in host metabolism and immunity, and microbial dysbiosis affects human physiology and health. Maternal immunity and microbial metabolites during pregnancy, microbial transfer during birth, and transfer of immune factors, microorganisms and metabolites via breastfeeding provide critical sources of early-life microbial and immune training, with important consequences for human health. Only a few studies have directly examined the interactions between the gut microbiome and the immune system during pregnancy, and the subsequent effect on offspring development. In this Review, we aim to describe how the maternal microbiome shapes overall pregnancy-associated maternal, fetal and early neonatal immune systems, focusing on the existing evidence and highlighting current gaps to promote further research.O.K. is supported by the European Research Council Consolidator grant (grant agreement no. 101001355). I.U.M. is supported by NIH/NICHD grant R01 HD091218 and 3R01HD091218-04S1(RADx-UP Supplement). O.K. and M.C.C. acknowledge the support by Biostime Institute Nutrition and Care (BINC) grant. L.K. is supported by Yale University pilot funds, Binational Science Foundation (2019075), and the National Institutes of Health (R21TR002639, R21HD102565, R01DK129552 and R01AI171980). P.B. is supported by grants from Knut and Alice Wallenberg Foundation (2019.0181), Svenska sällskapet för Medicinsk forskning, SSMF (CG-22-0148-H-02), the Swedish Research council (2019-01495, 2022-01567), EU Horizon project grant UNDINE (grant agreement: 101057100) and Wellcome Trust Discovery award (226507/Z/22/Z). M.C.C. was supported by a European Research Council Starting grant (grant agreement no. 639226), the Spanish Ministry of Science and Innovation (grant ref. PID2022-139475OB-I00), PROMETEO GVA (ref. 2020/012) and also from the Horizon Europe Program (INITIALISE- 101094099 project).With funding from the Spanish government through the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX 2021-001189-S)Peer reviewedSpringer NatureAgencia Estatal de Investigación (España)Generalitat ValencianaEuropean CommissionEuropean Research CouncilMinisterio de Ciencia e Innovación (España)0000-0002-7738-13370000-0003-4804-54970000-0002-8103-00460000-0003-3917-86770000-0002-6204-4864Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPostprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/341845https://api.elsevier.com/content/abstract/scopus_id/85179956602reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/H2020/639226info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-139475OB-I00info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/CEX2021-001189-SNature reviews. Gastroenterology & hepatologyhttps://doi.org/10.1038/s41575-023-00864-2Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3418452026-05-22T06:33:51Z
dc.title.none.fl_str_mv The maternal gut microbiome in pregnancy: implications for the developing immune system
title The maternal gut microbiome in pregnancy: implications for the developing immune system
spellingShingle The maternal gut microbiome in pregnancy: implications for the developing immune system
Koren, Omry
Gut
Microbiome
Immunity
Pregnancy
title_short The maternal gut microbiome in pregnancy: implications for the developing immune system
title_full The maternal gut microbiome in pregnancy: implications for the developing immune system
title_fullStr The maternal gut microbiome in pregnancy: implications for the developing immune system
title_full_unstemmed The maternal gut microbiome in pregnancy: implications for the developing immune system
title_sort The maternal gut microbiome in pregnancy: implications for the developing immune system
dc.creator.none.fl_str_mv Koren, Omry
Konnikova, Liza
Brodin, Petter
Mysorekar, Indira U.
Collado, María Carmen
author Koren, Omry
author_facet Koren, Omry
Konnikova, Liza
Brodin, Petter
Mysorekar, Indira U.
Collado, María Carmen
author_role author
author2 Konnikova, Liza
Brodin, Petter
Mysorekar, Indira U.
Collado, María Carmen
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Agencia Estatal de Investigación (España)
Generalitat Valenciana
European Commission
European Research Council
Ministerio de Ciencia e Innovación (España)
0000-0002-7738-1337
0000-0003-4804-5497
0000-0002-8103-0046
0000-0003-3917-8677
0000-0002-6204-4864
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Gut
Microbiome
Immunity
Pregnancy
topic Gut
Microbiome
Immunity
Pregnancy
description The gut microbiome has important roles in host metabolism and immunity, and microbial dysbiosis affects human physiology and health. Maternal immunity and microbial metabolites during pregnancy, microbial transfer during birth, and transfer of immune factors, microorganisms and metabolites via breastfeeding provide critical sources of early-life microbial and immune training, with important consequences for human health. Only a few studies have directly examined the interactions between the gut microbiome and the immune system during pregnancy, and the subsequent effect on offspring development. In this Review, we aim to describe how the maternal microbiome shapes overall pregnancy-associated maternal, fetal and early neonatal immune systems, focusing on the existing evidence and highlighting current gaps to promote further research.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/341845
https://api.elsevier.com/content/abstract/scopus_id/85179956602
url http://hdl.handle.net/10261/341845
https://api.elsevier.com/content/abstract/scopus_id/85179956602
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
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#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/H2020/639226
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-139475OB-I00
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/CEX2021-001189-S
Nature reviews. Gastroenterology & hepatology
https://doi.org/10.1038/s41575-023-00864-2
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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