Impact of the 13-Valent Conjugated Pneumococcal Vaccine on the Direct Costs of Invasive Pneumococcal Disease Requiring Hospital Admission in Children Aged < 5 Years: A Prospective Study

The lack of invasive pneumococcal disease (IPD) cost studies may underestimate the effect of pneumococcal polysaccharide conjugated vaccines (PCV). The objective of this study was to estimate the direct costs of hospitalized IPD cases. A prospective study was made in children aged <5 years diagno...

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Autores: Hernández S, Navas E, Aznar, I., Ciruela P, García, J., Moraga-Llop F, Muñoz, C., Codina G, Fernández de Sevilla, M., González-Peris S, Esteva, C., Planes AM, Izquierdo C, Martínez, J., Campins M, Uriona S, Salleras L, Serrano, A., Jané M, Domínguez A
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p17958
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=17958
Access Level:acceso abierto
Palabra clave:PCV7
PCV13
invasive pneumococcal disease
direct cost
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spelling Impact of the 13-Valent Conjugated Pneumococcal Vaccine on the Direct Costs of Invasive Pneumococcal Disease Requiring Hospital Admission in Children Aged &lt; 5 Years: A Prospective StudyHernández SNavas EAznar, I.Ciruela PGarcía, J.Moraga-Llop FMuñoz, C.Codina GFernández de Sevilla, M.González-Peris SEsteva, C.Planes AMIzquierdo CMartínez, J.Campins MUriona SSalleras LSerrano, A.Jané MDomínguez APCV7PCV13invasive pneumococcal diseasedirect costThe lack of invasive pneumococcal disease (IPD) cost studies may underestimate the effect of pneumococcal polysaccharide conjugated vaccines (PCV). The objective of this study was to estimate the direct costs of hospitalized IPD cases. A prospective study was made in children aged <5 years diagnosed with IPD in two high-tech hospitals in Catalonia (Spain) between 2007-2009 (PCV7 period) and 2012-2015 (PCV13 period). Costs were calculated according to 2014 Catalan Health Service rates using diagnostic-related groups. In total, 319 and 154 cases were collected, respectively. Pneumonia had the highest cost (65.7% and 62.0%, respectively), followed by meningitis (25.8% and 26.1%, respectively). During 2007-2015, the costs associated with PCV7 serotypes (Pearson coefficient (Pc) = -0.79;p= 0.036) and additional PCV13 serotypes (Pc = -0.75;p= 0.05) decreased, but those of other serotypes did not (Pc = 0.23p= 0.62). The total mean cost of IPD increased in the PCV13 period by 31.4% (euro3016.1 vs. euro3963.9), mainly due to ICU stay (77.4%; euro1051.4 vs. euro1865.6). During the PCV13 period, direct IPD costs decreased due to a reduction in the number of cases, but cases were more severe and had a higher mean cost. During 2015, IPD costs increased due to an increase in the costs associated with non-PCV13 serotypes and serotype 3 and this requires further investigation.MDPI2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=17958VaccinesISSN: 2076393Xreponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p179582026-05-27T12:37:41Z
dc.title.none.fl_str_mv Impact of the 13-Valent Conjugated Pneumococcal Vaccine on the Direct Costs of Invasive Pneumococcal Disease Requiring Hospital Admission in Children Aged &lt; 5 Years: A Prospective Study
title Impact of the 13-Valent Conjugated Pneumococcal Vaccine on the Direct Costs of Invasive Pneumococcal Disease Requiring Hospital Admission in Children Aged &lt; 5 Years: A Prospective Study
spellingShingle Impact of the 13-Valent Conjugated Pneumococcal Vaccine on the Direct Costs of Invasive Pneumococcal Disease Requiring Hospital Admission in Children Aged &lt; 5 Years: A Prospective Study
Hernández S
PCV7
PCV13
invasive pneumococcal disease
direct cost
title_short Impact of the 13-Valent Conjugated Pneumococcal Vaccine on the Direct Costs of Invasive Pneumococcal Disease Requiring Hospital Admission in Children Aged &lt; 5 Years: A Prospective Study
title_full Impact of the 13-Valent Conjugated Pneumococcal Vaccine on the Direct Costs of Invasive Pneumococcal Disease Requiring Hospital Admission in Children Aged &lt; 5 Years: A Prospective Study
title_fullStr Impact of the 13-Valent Conjugated Pneumococcal Vaccine on the Direct Costs of Invasive Pneumococcal Disease Requiring Hospital Admission in Children Aged &lt; 5 Years: A Prospective Study
title_full_unstemmed Impact of the 13-Valent Conjugated Pneumococcal Vaccine on the Direct Costs of Invasive Pneumococcal Disease Requiring Hospital Admission in Children Aged &lt; 5 Years: A Prospective Study
title_sort Impact of the 13-Valent Conjugated Pneumococcal Vaccine on the Direct Costs of Invasive Pneumococcal Disease Requiring Hospital Admission in Children Aged &lt; 5 Years: A Prospective Study
dc.creator.none.fl_str_mv Hernández S
Navas E
Aznar, I.
Ciruela P
García, J.
Moraga-Llop F
Muñoz, C.
Codina G
Fernández de Sevilla, M.
González-Peris S
Esteva, C.
Planes AM
Izquierdo C
Martínez, J.
Campins M
Uriona S
Salleras L
Serrano, A.
Jané M
Domínguez A
author Hernández S
author_facet Hernández S
Navas E
Aznar, I.
Ciruela P
García, J.
Moraga-Llop F
Muñoz, C.
Codina G
Fernández de Sevilla, M.
González-Peris S
Esteva, C.
Planes AM
Izquierdo C
Martínez, J.
Campins M
Uriona S
Salleras L
Serrano, A.
Jané M
Domínguez A
author_role author
author2 Navas E
Aznar, I.
Ciruela P
García, J.
Moraga-Llop F
Muñoz, C.
Codina G
Fernández de Sevilla, M.
González-Peris S
Esteva, C.
Planes AM
Izquierdo C
Martínez, J.
Campins M
Uriona S
Salleras L
Serrano, A.
Jané M
Domínguez A
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv PCV7
PCV13
invasive pneumococcal disease
direct cost
topic PCV7
PCV13
invasive pneumococcal disease
direct cost
description The lack of invasive pneumococcal disease (IPD) cost studies may underestimate the effect of pneumococcal polysaccharide conjugated vaccines (PCV). The objective of this study was to estimate the direct costs of hospitalized IPD cases. A prospective study was made in children aged <5 years diagnosed with IPD in two high-tech hospitals in Catalonia (Spain) between 2007-2009 (PCV7 period) and 2012-2015 (PCV13 period). Costs were calculated according to 2014 Catalan Health Service rates using diagnostic-related groups. In total, 319 and 154 cases were collected, respectively. Pneumonia had the highest cost (65.7% and 62.0%, respectively), followed by meningitis (25.8% and 26.1%, respectively). During 2007-2015, the costs associated with PCV7 serotypes (Pearson coefficient (Pc) = -0.79;p= 0.036) and additional PCV13 serotypes (Pc = -0.75;p= 0.05) decreased, but those of other serotypes did not (Pc = 0.23p= 0.62). The total mean cost of IPD increased in the PCV13 period by 31.4% (euro3016.1 vs. euro3963.9), mainly due to ICU stay (77.4%; euro1051.4 vs. euro1865.6). During the PCV13 period, direct IPD costs decreased due to a reduction in the number of cases, but cases were more severe and had a higher mean cost. During 2015, IPD costs increased due to an increase in the costs associated with non-PCV13 serotypes and serotype 3 and this requires further investigation.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=17958
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=17958
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Vaccines
ISSN: 2076393X
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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