Pneumococcal serotypes in children, clinical presentation and antimicrobial susceptibility in the PCV13 era

The aim was to analyse invasive pneumococcal disease (IPD) serotypes in children aged ⩽17 years according to clinical presentation and antimicrobial susceptibility. We conducted a prospective study (January 2012-June 2016). IPD cases were diagnosed by culture and/or real-time polymerase chain reacti...

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Detalles Bibliográficos
Autores: Izquierdo, Conchita|||0000-0003-2611-6055, Ciruela, Pilar|||0000-0003-0842-7220, Hernández Baeza, Sergi|||0000-0002-0461-6190, García-García, J. J., Esteva, C., Moraga-Llop, F., Díaz-Conradi, A., Martínez-Osorio, J., Solé-Ribalta, Anna, de Sevilla, M. F., González-Peris, S., Codina, María Gema|||0000-0002-5313-5086, Planes, A. M., Uriona, S., Campins Martí, Magda|||0000-0002-8841-6195, Muñoz-Almagro, C., Salleras, L., Domínguez, Ángela|||0000-0003-0219-1907
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:253054
Acceso en línea:https://ddd.uab.cat/record/253054
https://dx.doi.org/urn:doi:10.1017/S0950268820002708
Access Level:acceso abierto
Palabra clave:Antimicrobial susceptibility
Invasive pneumococcal disease
PCV13 vaccine
Penicillin resistance
Serotype distribution
Streptococcus pneumoniae
Descripción
Sumario:The aim was to analyse invasive pneumococcal disease (IPD) serotypes in children aged ⩽17 years according to clinical presentation and antimicrobial susceptibility. We conducted a prospective study (January 2012-June 2016). IPD cases were diagnosed by culture and/or real-time polymerase chain reaction (PCR). Demographic, microbiological and clinical data were analysed. Associations were assessed using the odds ratio (OR) and 95% confidence intervals (CI). Of the 253 cases, 34.4% were aged <2 years, 38.7% 2-4 years and 26.9% 5-17 years. Over 64% were 13-valent pneumococcal conjugate vaccine (PCV13) serotypes. 48% of the cases were diagnosed only by real-time PCR. Serotypes 3 and 1 were associated with complicated pneumonia (P < 0.05) and non-PCV13 serotypes with meningitis (OR 7.32, 95% CI 2.33-22.99) and occult bacteraemia (OR 3.6, 95% CI 1.56-8.76). Serotype 19A was more frequent in children aged <2 years and serotypes 3 and 1 in children aged 2-4 years and 5-17 years, respectively. 36.1% of cases were not susceptible to penicillin and 16.4% were also non-susceptible to cefotaxime. Serotypes 14, 24F and 23B were associated with non-susceptibility to penicillin (P < 0.05) and serotypes 11, 14 and 19A to cefotaxime (P < 0.05). Serotype 19A showed resistance to penicillin (P = 0.002). In conclusion, PCV13 serotypes were most frequent in children aged ⩽17 years, mainly serotypes 3, 1 and 19A. Non-PCV13 serotypes were associated with meningitis and occult bacteraemia and PCV13 serotypes with pneumonia. Non-susceptibility to antibiotics of non-PCV13 serotypes should be monitored PI11/02081 and PI11/02345).

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