Invasive Cell Behavior during Drosophila Imaginal Disc Eversion Is Mediated by the JNK Signaling Cascade

Drosophila imaginal discs are monolayered epithelial invaginations that grow during larval stages and evert at metamorphosis to assemble the adult exoskeleton. They consist of columnar cells, forming the imaginal epithelium, as well as squamous cells, which constitute the peripodial epithelium and s...

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Detalles Bibliográficos
Autores: Pastor-Pareja, José Carlos, Grawe, Ferdinand, Martín-Blanco, Enrique, García-Bellido, Antonio
Tipo de recurso: artículo
Fecha de publicación:2004
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/48424
Acceso en línea:http://hdl.handle.net/10261/48424
Access Level:acceso embargado
Palabra clave:Drosophila
Larvae
Imaginal
Disc
Exoskeleton
PEMT
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repository_id_str
spelling Invasive Cell Behavior during Drosophila Imaginal Disc Eversion Is Mediated by the JNK Signaling CascadePastor-Pareja, José CarlosGrawe, FerdinandMartín-Blanco, EnriqueGarcía-Bellido, AntonioDrosophilaLarvaeImaginalDiscExoskeletonPEMTDrosophila imaginal discs are monolayered epithelial invaginations that grow during larval stages and evert at metamorphosis to assemble the adult exoskeleton. They consist of columnar cells, forming the imaginal epithelium, as well as squamous cells, which constitute the peripodial epithelium and stalk (PS). Here, we uncover a new morphogenetic/cellular mechanism for disc eversion. We show that imaginal discs evert by apposing their peripodial side to the larval epidermis and through the invasion of the larval epidermis by PS cells, which undergo a pseudo-epithelial-mesenchymal transition (PEMT). As a consequence, the PS/larval bilayer is perforated and the imaginal epithelia protrude, a process reminiscent of other developmental events, such as epithelial perforation in chordates. When eversion is completed, PS cells localize to the leading front, heading disc expansion. We found that the JNK pathway is necessary for PS/larval cells apposition, the PEMT, and the motile activity of leading front cells.Peer reviewedCell PressConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201220122004info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/48424reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1016/j.devcel.2004.07.022Síinfo:eu-repo/semantics/embargoedAccessoai:digital.csic.es:10261/484242026-05-22T06:33:51Z
dc.title.none.fl_str_mv Invasive Cell Behavior during Drosophila Imaginal Disc Eversion Is Mediated by the JNK Signaling Cascade
title Invasive Cell Behavior during Drosophila Imaginal Disc Eversion Is Mediated by the JNK Signaling Cascade
spellingShingle Invasive Cell Behavior during Drosophila Imaginal Disc Eversion Is Mediated by the JNK Signaling Cascade
Pastor-Pareja, José Carlos
Drosophila
Larvae
Imaginal
Disc
Exoskeleton
PEMT
title_short Invasive Cell Behavior during Drosophila Imaginal Disc Eversion Is Mediated by the JNK Signaling Cascade
title_full Invasive Cell Behavior during Drosophila Imaginal Disc Eversion Is Mediated by the JNK Signaling Cascade
title_fullStr Invasive Cell Behavior during Drosophila Imaginal Disc Eversion Is Mediated by the JNK Signaling Cascade
title_full_unstemmed Invasive Cell Behavior during Drosophila Imaginal Disc Eversion Is Mediated by the JNK Signaling Cascade
title_sort Invasive Cell Behavior during Drosophila Imaginal Disc Eversion Is Mediated by the JNK Signaling Cascade
dc.creator.none.fl_str_mv Pastor-Pareja, José Carlos
Grawe, Ferdinand
Martín-Blanco, Enrique
García-Bellido, Antonio
author Pastor-Pareja, José Carlos
author_facet Pastor-Pareja, José Carlos
Grawe, Ferdinand
Martín-Blanco, Enrique
García-Bellido, Antonio
author_role author
author2 Grawe, Ferdinand
Martín-Blanco, Enrique
García-Bellido, Antonio
author2_role author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Drosophila
Larvae
Imaginal
Disc
Exoskeleton
PEMT
topic Drosophila
Larvae
Imaginal
Disc
Exoskeleton
PEMT
description Drosophila imaginal discs are monolayered epithelial invaginations that grow during larval stages and evert at metamorphosis to assemble the adult exoskeleton. They consist of columnar cells, forming the imaginal epithelium, as well as squamous cells, which constitute the peripodial epithelium and stalk (PS). Here, we uncover a new morphogenetic/cellular mechanism for disc eversion. We show that imaginal discs evert by apposing their peripodial side to the larval epidermis and through the invasion of the larval epidermis by PS cells, which undergo a pseudo-epithelial-mesenchymal transition (PEMT). As a consequence, the PS/larval bilayer is perforated and the imaginal epithelia protrude, a process reminiscent of other developmental events, such as epithelial perforation in chordates. When eversion is completed, PS cells localize to the leading front, heading disc expansion. We found that the JNK pathway is necessary for PS/larval cells apposition, the PEMT, and the motile activity of leading front cells.
publishDate 2004
dc.date.none.fl_str_mv 2004
2012
2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/48424
url http://hdl.handle.net/10261/48424
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1016/j.devcel.2004.07.022
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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