Pulmonary cytomegalovirus (CMV) DNA shedding in allogeneic hematopoietic stem cell transplant recipients: Implications for the diagnosis of CMV pneumonia

Objectives: To date no definitive cut-off value for cytomegalovirus (CMV) DNA load in bronchoalveolar lavage (BAL) fluid specimens has been established to discriminate between CMV pneumonia and pulmonary CMV DNA shedding in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients. Method...

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Autores: Piñana JL, Gimenez, E, Gomez, MD, Perez, A, Gonzalez, EM, Vinuesa, V, Hernandez-Boluda, JC, Montoro, J, Salavert, M, Tormo, M, Amat, P, Moles, P, Carretero, C, Balaguer-Rosello, A, Sanz, J, Sanz, G, Solano, C, Navarro, D
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2019
País:España
Recursos:INCLIVA
Repositório:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p2858
Acesso em linha:https://incliva.portalinvestigacion.com/publicaciones/2858
Access Level:Acceso aberto
Palavra-chave:Cytomegalovirus
CMV DNA in BAL
CMV pneumonia
CMV DNAemia
Pre-emptive antiviral therapy
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spelling Pulmonary cytomegalovirus (CMV) DNA shedding in allogeneic hematopoietic stem cell transplant recipients: Implications for the diagnosis of CMV pneumoniaPiñana JLGimenez, EGomez, MDPerez, AGonzalez, EMVinuesa, VHernandez-Boluda, JCMontoro, JSalavert, MTormo, MAmat, PMoles, PCarretero, CBalaguer-Rosello, ASanz, JSanz, GSolano, CNavarro, DCytomegalovirusCMV DNA in BALCMV pneumoniaCMV DNAemiaPre-emptive antiviral therapyObjectives: To date no definitive cut-off value for cytomegalovirus (CMV) DNA load in bronchoalveolar lavage (BAL) fluid specimens has been established to discriminate between CMV pneumonia and pulmonary CMV DNA shedding in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients. Methods: The current retrospective study is aimed at assessing the range of CMV DNA loads quantified in BAL fluid specimens from allo-HSCT patients with pneumonia in which different microorganisms were causally involved. Results: A total of 144 BAL specimens from 123 patients were included. CMV DNA was detected in 56 out of 144 BAL fluid specimens and the median CMV DNA load from patients in whom CMV pneumonia was unlikely or could be tentatively ruled out was 1210 (31-68, 920) IU/ml. The frequency of CMV DNA detection and median CMV DNA loads were comparable, irrespective of the attributable cause of pneumonia. Detection of CMV DNA loads in BAL fluid specimens >500 IU/ml was independently associated with pneumonia-attributable mortality. Conclusions: The current study highlights the difficulty in establishing universal CMV DNA load thresholds in BAL fluid specimens for distinguishing between CMV pneumonia and pulmonary CMV DNA shedding, and suggests that the presence of CMV DNA in BAL fluid specimens beyond a certain level may have a deleterious impact on patient outcome. (C) 2019 The British Infection Association. Published by Elsevier Ltd. All rights reserved.W B SAUNDERS CO LTD2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/2858JOURNAL OF INFECTIONISSN: 01634453ISSNe: 15322742reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p28582026-06-07T16:35:31Z
dc.title.none.fl_str_mv Pulmonary cytomegalovirus (CMV) DNA shedding in allogeneic hematopoietic stem cell transplant recipients: Implications for the diagnosis of CMV pneumonia
title Pulmonary cytomegalovirus (CMV) DNA shedding in allogeneic hematopoietic stem cell transplant recipients: Implications for the diagnosis of CMV pneumonia
spellingShingle Pulmonary cytomegalovirus (CMV) DNA shedding in allogeneic hematopoietic stem cell transplant recipients: Implications for the diagnosis of CMV pneumonia
Piñana JL
Cytomegalovirus
CMV DNA in BAL
CMV pneumonia
CMV DNAemia
Pre-emptive antiviral therapy
title_short Pulmonary cytomegalovirus (CMV) DNA shedding in allogeneic hematopoietic stem cell transplant recipients: Implications for the diagnosis of CMV pneumonia
title_full Pulmonary cytomegalovirus (CMV) DNA shedding in allogeneic hematopoietic stem cell transplant recipients: Implications for the diagnosis of CMV pneumonia
title_fullStr Pulmonary cytomegalovirus (CMV) DNA shedding in allogeneic hematopoietic stem cell transplant recipients: Implications for the diagnosis of CMV pneumonia
title_full_unstemmed Pulmonary cytomegalovirus (CMV) DNA shedding in allogeneic hematopoietic stem cell transplant recipients: Implications for the diagnosis of CMV pneumonia
title_sort Pulmonary cytomegalovirus (CMV) DNA shedding in allogeneic hematopoietic stem cell transplant recipients: Implications for the diagnosis of CMV pneumonia
dc.creator.none.fl_str_mv Piñana JL
Gimenez, E
Gomez, MD
Perez, A
Gonzalez, EM
Vinuesa, V
Hernandez-Boluda, JC
Montoro, J
Salavert, M
Tormo, M
Amat, P
Moles, P
Carretero, C
Balaguer-Rosello, A
Sanz, J
Sanz, G
Solano, C
Navarro, D
author Piñana JL
author_facet Piñana JL
Gimenez, E
Gomez, MD
Perez, A
Gonzalez, EM
Vinuesa, V
Hernandez-Boluda, JC
Montoro, J
Salavert, M
Tormo, M
Amat, P
Moles, P
Carretero, C
Balaguer-Rosello, A
Sanz, J
Sanz, G
Solano, C
Navarro, D
author_role author
author2 Gimenez, E
Gomez, MD
Perez, A
Gonzalez, EM
Vinuesa, V
Hernandez-Boluda, JC
Montoro, J
Salavert, M
Tormo, M
Amat, P
Moles, P
Carretero, C
Balaguer-Rosello, A
Sanz, J
Sanz, G
Solano, C
Navarro, D
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cytomegalovirus
CMV DNA in BAL
CMV pneumonia
CMV DNAemia
Pre-emptive antiviral therapy
topic Cytomegalovirus
CMV DNA in BAL
CMV pneumonia
CMV DNAemia
Pre-emptive antiviral therapy
description Objectives: To date no definitive cut-off value for cytomegalovirus (CMV) DNA load in bronchoalveolar lavage (BAL) fluid specimens has been established to discriminate between CMV pneumonia and pulmonary CMV DNA shedding in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients. Methods: The current retrospective study is aimed at assessing the range of CMV DNA loads quantified in BAL fluid specimens from allo-HSCT patients with pneumonia in which different microorganisms were causally involved. Results: A total of 144 BAL specimens from 123 patients were included. CMV DNA was detected in 56 out of 144 BAL fluid specimens and the median CMV DNA load from patients in whom CMV pneumonia was unlikely or could be tentatively ruled out was 1210 (31-68, 920) IU/ml. The frequency of CMV DNA detection and median CMV DNA loads were comparable, irrespective of the attributable cause of pneumonia. Detection of CMV DNA loads in BAL fluid specimens >500 IU/ml was independently associated with pneumonia-attributable mortality. Conclusions: The current study highlights the difficulty in establishing universal CMV DNA load thresholds in BAL fluid specimens for distinguishing between CMV pneumonia and pulmonary CMV DNA shedding, and suggests that the presence of CMV DNA in BAL fluid specimens beyond a certain level may have a deleterious impact on patient outcome. (C) 2019 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://incliva.portalinvestigacion.com/publicaciones/2858
url https://incliva.portalinvestigacion.com/publicaciones/2858
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv W B SAUNDERS CO LTD
publisher.none.fl_str_mv W B SAUNDERS CO LTD
dc.source.none.fl_str_mv JOURNAL OF INFECTION
ISSN: 01634453
ISSNe: 15322742
reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname:INCLIVA
instname_str INCLIVA
reponame_str r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
collection r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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