Gluten Free Wheat: Are We There?

This article belongs to the Special Issue Nutrition, Diet and Celiac Disease.

Detalles Bibliográficos
Autores: García-Molina, María D., Giménez, María J., Sánchez-León, Susana, Barro Losada, Francisco
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/207335
Acceso en línea:http://hdl.handle.net/10261/207335
Access Level:acceso abierto
Palabra clave:Gluten
Coeliac disease
NCWS
Transgenic wheat
RNAi
CRISPR/Cas9
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spelling Gluten Free Wheat: Are We There?García-Molina, María D.Giménez, María J.Sánchez-León, SusanaBarro Losada, FranciscoGlutenCoeliac diseaseNCWSTransgenic wheatRNAiCRISPR/Cas9This article belongs to the Special Issue Nutrition, Diet and Celiac Disease.Gluten proteins, major determinants of the bread-making quality of wheat, are related to several digestive disorders. Advances in plant genetic breeding have allowed the production of wheat lines with very low gliadin content through the use of RNAi and gene editing technologies. In this review, we carried out a comprehensive study of the application of these cutting-edge technologies towards the development of wheat lines devoid of immunogenic gluten, and their genetic, nutritional and clinical characterization. One line, named E82, showed outstanding nutritional properties, with very low immunogenic gluten and a low stimulation capacity of T-cells from celiac patients. Moreover, a clinical trial with non-celiac wheat sensitivity (NCWS) patients showed that the consumption of bread made with this E82 low gliadin line induced positive changes in the gut microbiota composition.This research was funded by the Spanish Ministry of Economy and Competitiveness (Projects AGL2013-48946-C3-1-R and AGL2016-80566-P), the European Regional Development Fund (FEDER) and Junta de Andalucía (Project P11-AGR-7920).Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Economía y Competitividad (España)Junta de AndalucíaEuropean CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202020202019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/207335reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2013-48946-C3-1-Rinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2016-80566-Phttps://doi.org/10.3390/nu11030487Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2073352026-05-22T06:33:51Z
dc.title.none.fl_str_mv Gluten Free Wheat: Are We There?
title Gluten Free Wheat: Are We There?
spellingShingle Gluten Free Wheat: Are We There?
García-Molina, María D.
Gluten
Coeliac disease
NCWS
Transgenic wheat
RNAi
CRISPR/Cas9
title_short Gluten Free Wheat: Are We There?
title_full Gluten Free Wheat: Are We There?
title_fullStr Gluten Free Wheat: Are We There?
title_full_unstemmed Gluten Free Wheat: Are We There?
title_sort Gluten Free Wheat: Are We There?
dc.creator.none.fl_str_mv García-Molina, María D.
Giménez, María J.
Sánchez-León, Susana
Barro Losada, Francisco
author García-Molina, María D.
author_facet García-Molina, María D.
Giménez, María J.
Sánchez-León, Susana
Barro Losada, Francisco
author_role author
author2 Giménez, María J.
Sánchez-León, Susana
Barro Losada, Francisco
author2_role author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Junta de Andalucía
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Gluten
Coeliac disease
NCWS
Transgenic wheat
RNAi
CRISPR/Cas9
topic Gluten
Coeliac disease
NCWS
Transgenic wheat
RNAi
CRISPR/Cas9
description This article belongs to the Special Issue Nutrition, Diet and Celiac Disease.
publishDate 2019
dc.date.none.fl_str_mv 2019
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/207335
url http://hdl.handle.net/10261/207335
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2013-48946-C3-1-R
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2016-80566-P
https://doi.org/10.3390/nu11030487
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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repository.mail.fl_str_mv
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