Experimental study of hybrid-knife endoscopic submucosal dissection (ESD) versus standard ESD in a Western country

BACKGROUND: Endoscopic submucosal dissection (ESD) is an effective but time-consuming treatment for early neoplasia that requires a high level of expertise. OBJECTIVE: The objective of this study was to assess the efficacy and learning curve of gastric ESD with a hybrid knife with high pressure wate...

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Autores: Peña, Joaquín de la, Calderón, Ángel, Esteban, José M., López Rosés, Leopoldo, Martínez Ares, David, Nogales, Óscar, Orive Calzada, Aitor, Rodríguez Muñoz, Sarbelio, Sánchez Hernández, Eloy, Vila, Juan, Fernández Esparrach, Glòria
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/119054
Acceso en línea:https://hdl.handle.net/2445/119054
Access Level:acceso abierto
Palabra clave:Endoscòpia
Mucosa gastrointestinal
Cirurgia digestiva
Endoscopy
Gastrointestinal mucosa
Gastrointestinal surgery
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spelling Experimental study of hybrid-knife endoscopic submucosal dissection (ESD) versus standard ESD in a Western countryPeña, Joaquín de laCalderón, ÁngelEsteban, José M.López Rosés, LeopoldoMartínez Ares, DavidNogales, ÓscarOrive Calzada, AitorRodríguez Muñoz, SarbelioSánchez Hernández, EloyVila, JuanFernández Esparrach, GlòriaEndoscòpiaMucosa gastrointestinalCirurgia digestivaEndoscopyGastrointestinal mucosaGastrointestinal surgeryBACKGROUND: Endoscopic submucosal dissection (ESD) is an effective but time-consuming treatment for early neoplasia that requires a high level of expertise. OBJECTIVE: The objective of this study was to assess the efficacy and learning curve of gastric ESD with a hybrid knife with high pressure water jet and to compare with standard ESD. MATERIAL AND METHODS: We performed a prospective non survival animal study comparing hybrid-knife and standard gastric ESD. Variables recorded were: Number of en-bloc ESD, number of ESD with all marks included (R0), size of specimens, time and speed of dissection and adverse events. Ten endoscopists performed a total of 50 gastric ESD (30 hybrid-knife and 20 standard). RESULTS: Forty-six (92 %) ESD were en-bloc and 25 (50 %) R0 (hybrid-knife: n = 13, 44 %; standard: n = 16, 80 %; p = 0.04). Hybrid-knife ESD was faster than standard (time: 44.6 +/- 21.4 minutes vs. 68.7 +/- 33.5 minutes; p = 0.009 and velocity: 20.8 +/- 9.2 mm(2)/min vs. 14.3 +/- 9.3 mm(2)/min (p = 0.079). Adverse events were not different. There was no change in speed with any of two techniques (hybrid-knife: From 20.33 +/- 15.68 to 28.18 +/- 20.07 mm(2)/min; p = 0.615 and standard: From 6.4 +/- 0.3 to 19.48 +/- 19.21 mm(2)/min; p = 0.607). The learning curve showed a significant improvement in R0 rate in the hybrid-knife group (from 30 % to 100 %). CONCLUSION: despite the initial performance of hybrid-knife ESD is worse than standard ESD, the learning curve with hybrid knife ESD is short and is associated with a rapid improvement. The introduction of new tools to facilitate ESD should be implemented with caution in order to avoid a negative impact on the results.Aran Ediciones2018201820142018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion5 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/119054Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a:Revista Española de Enfermedades Digestivas, 2014, vol. 106, num. 2, p. 98-102(c) Aran Ediciones, 2014info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1190542026-05-29T05:05:01Z
dc.title.none.fl_str_mv Experimental study of hybrid-knife endoscopic submucosal dissection (ESD) versus standard ESD in a Western country
title Experimental study of hybrid-knife endoscopic submucosal dissection (ESD) versus standard ESD in a Western country
spellingShingle Experimental study of hybrid-knife endoscopic submucosal dissection (ESD) versus standard ESD in a Western country
Peña, Joaquín de la
Endoscòpia
Mucosa gastrointestinal
Cirurgia digestiva
Endoscopy
Gastrointestinal mucosa
Gastrointestinal surgery
title_short Experimental study of hybrid-knife endoscopic submucosal dissection (ESD) versus standard ESD in a Western country
title_full Experimental study of hybrid-knife endoscopic submucosal dissection (ESD) versus standard ESD in a Western country
title_fullStr Experimental study of hybrid-knife endoscopic submucosal dissection (ESD) versus standard ESD in a Western country
title_full_unstemmed Experimental study of hybrid-knife endoscopic submucosal dissection (ESD) versus standard ESD in a Western country
title_sort Experimental study of hybrid-knife endoscopic submucosal dissection (ESD) versus standard ESD in a Western country
dc.creator.none.fl_str_mv Peña, Joaquín de la
Calderón, Ángel
Esteban, José M.
López Rosés, Leopoldo
Martínez Ares, David
Nogales, Óscar
Orive Calzada, Aitor
Rodríguez Muñoz, Sarbelio
Sánchez Hernández, Eloy
Vila, Juan
Fernández Esparrach, Glòria
author Peña, Joaquín de la
author_facet Peña, Joaquín de la
Calderón, Ángel
Esteban, José M.
López Rosés, Leopoldo
Martínez Ares, David
Nogales, Óscar
Orive Calzada, Aitor
Rodríguez Muñoz, Sarbelio
Sánchez Hernández, Eloy
Vila, Juan
Fernández Esparrach, Glòria
author_role author
author2 Calderón, Ángel
Esteban, José M.
López Rosés, Leopoldo
Martínez Ares, David
Nogales, Óscar
Orive Calzada, Aitor
Rodríguez Muñoz, Sarbelio
Sánchez Hernández, Eloy
Vila, Juan
Fernández Esparrach, Glòria
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Endoscòpia
Mucosa gastrointestinal
Cirurgia digestiva
Endoscopy
Gastrointestinal mucosa
Gastrointestinal surgery
topic Endoscòpia
Mucosa gastrointestinal
Cirurgia digestiva
Endoscopy
Gastrointestinal mucosa
Gastrointestinal surgery
description BACKGROUND: Endoscopic submucosal dissection (ESD) is an effective but time-consuming treatment for early neoplasia that requires a high level of expertise. OBJECTIVE: The objective of this study was to assess the efficacy and learning curve of gastric ESD with a hybrid knife with high pressure water jet and to compare with standard ESD. MATERIAL AND METHODS: We performed a prospective non survival animal study comparing hybrid-knife and standard gastric ESD. Variables recorded were: Number of en-bloc ESD, number of ESD with all marks included (R0), size of specimens, time and speed of dissection and adverse events. Ten endoscopists performed a total of 50 gastric ESD (30 hybrid-knife and 20 standard). RESULTS: Forty-six (92 %) ESD were en-bloc and 25 (50 %) R0 (hybrid-knife: n = 13, 44 %; standard: n = 16, 80 %; p = 0.04). Hybrid-knife ESD was faster than standard (time: 44.6 +/- 21.4 minutes vs. 68.7 +/- 33.5 minutes; p = 0.009 and velocity: 20.8 +/- 9.2 mm(2)/min vs. 14.3 +/- 9.3 mm(2)/min (p = 0.079). Adverse events were not different. There was no change in speed with any of two techniques (hybrid-knife: From 20.33 +/- 15.68 to 28.18 +/- 20.07 mm(2)/min; p = 0.615 and standard: From 6.4 +/- 0.3 to 19.48 +/- 19.21 mm(2)/min; p = 0.607). The learning curve showed a significant improvement in R0 rate in the hybrid-knife group (from 30 % to 100 %). CONCLUSION: despite the initial performance of hybrid-knife ESD is worse than standard ESD, the learning curve with hybrid knife ESD is short and is associated with a rapid improvement. The introduction of new tools to facilitate ESD should be implemented with caution in order to avoid a negative impact on the results.
publishDate 2014
dc.date.none.fl_str_mv 2014
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/119054
url https://hdl.handle.net/2445/119054
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a:
Revista Española de Enfermedades Digestivas, 2014, vol. 106, num. 2, p. 98-102
dc.rights.none.fl_str_mv (c) Aran Ediciones, 2014
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Aran Ediciones, 2014
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 5 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Aran Ediciones
publisher.none.fl_str_mv Aran Ediciones
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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