Magnetically propelled chained nanocomposites for biologically relevant media exploration

Elongated nanostructures to be remotely and magnetically propelled in biologically relevant media, have gained attention as offering themselves as effective tools or carriers in theragnostics applications. However, the magnetic actuation associated remains challenging due to the lack of mechanical i...

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Autores: Ramos-Docampo, Miguel A, Hurtado, Pablo, Dávila-Ibáñez, Ana B, Piñeiro, Roberto, López Fanarraga, Mónica|||0000-0003-4754-311X, Salgueiriño, Verónica
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/26552
Acceso en línea:https://hdl.handle.net/10902/26552
Access Level:acceso abierto
Palabra clave:Magnetic swimmers
Magnetophoretic mobility
Viscosity
Zebrafish yolk sac
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spelling Magnetically propelled chained nanocomposites for biologically relevant media explorationRamos-Docampo, Miguel AHurtado, PabloDávila-Ibáñez, Ana BPiñeiro, RobertoLópez Fanarraga, Mónica|||0000-0003-4754-311XSalgueiriño, VerónicaMagnetic swimmersMagnetophoretic mobilityViscosityZebrafish yolk sacElongated nanostructures to be remotely and magnetically propelled in biologically relevant media, have gained attention as offering themselves as effective tools or carriers in theragnostics applications. However, the magnetic actuation associated remains challenging due to the lack of mechanical information in the media of interest, taking into account biophysical or biomedical purposes. In this study, we detail the magnetic actuation of magnetically propelled chained nanocomposites considering their dynamics, in which their velocity can be modulated in terms of the viscosity of the medium considered, given a magnetic field gradient. Simpler cases of distilled water, a water/glycerol mixture and a fluid made of cell extracts (imitating the cytosol of cells) of known viscosity are the basis experiments for the study of more complex media inside HeLa cells, murine NIH-3T3 fibroblasts and zebrafish larvae, offering the mechanical information required. The experimental results indicate that the magnetically propelled performance of the chained nanostructures can be precisely controlled in potentially changing scenarios, where drug and heat delivery, magnetic separation, or microfluidic technologies are demanded, using a magnetic field gradient and providing good estimations of the dynamical parameters involved.Acknowledgments: M. A. R.-D. acknowledges financial support from the Xunta de Galicia (Regional Government, Spain) under grant 2017-ED481A/322. P. H. is a recipient of a Predoctoral fellowship (IN606A-2018/019) from Axencia Galega de Innovación (GAIN, Xunta de Galicia). R. P. and A. B. D.-I. are supported by Roche-Chus Joint Unit (IN853B 2018/03) funded by GAIN, Consellería de Economía, Emprego e Industria, Xunta de Galicia. A. B. D.-I. acknowledges financial support from the Ministerio de Economía y Competitividad under Sara Borrell contract. M. L. F. acknowledge the financial support from the Spanish MINECO, Instituto de Salud Carlos III and the European Union FEDER funds under Projects ref. PI16/00496, PI19/00349, DTS19/00033 and the NanoBioApp Network (MINECO-17-MAT2016-81955-REDT). V. S. acknowledges the financial support from the Spanish Ministerio de Ciencia e Innovación under project PID2020-119242-I00 and from the European Union under project H2020-MSCA-RISE-2019 PEPSA-MATE (project number 872233). V. S. acknowledges for funding for open access charge: Universidade de Vigo/CISUG.ElsevierUniversidad de Cantabria20232023-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttps://hdl.handle.net/10902/26552J Colloid Interface Sci . Volume 629, Part A, January 2023, Pages 287-296reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/265522026-06-02T12:39:31Z
dc.title.none.fl_str_mv Magnetically propelled chained nanocomposites for biologically relevant media exploration
title Magnetically propelled chained nanocomposites for biologically relevant media exploration
spellingShingle Magnetically propelled chained nanocomposites for biologically relevant media exploration
Ramos-Docampo, Miguel A
Magnetic swimmers
Magnetophoretic mobility
Viscosity
Zebrafish yolk sac
title_short Magnetically propelled chained nanocomposites for biologically relevant media exploration
title_full Magnetically propelled chained nanocomposites for biologically relevant media exploration
title_fullStr Magnetically propelled chained nanocomposites for biologically relevant media exploration
title_full_unstemmed Magnetically propelled chained nanocomposites for biologically relevant media exploration
title_sort Magnetically propelled chained nanocomposites for biologically relevant media exploration
dc.creator.none.fl_str_mv Ramos-Docampo, Miguel A
Hurtado, Pablo
Dávila-Ibáñez, Ana B
Piñeiro, Roberto
López Fanarraga, Mónica|||0000-0003-4754-311X
Salgueiriño, Verónica
author Ramos-Docampo, Miguel A
author_facet Ramos-Docampo, Miguel A
Hurtado, Pablo
Dávila-Ibáñez, Ana B
Piñeiro, Roberto
López Fanarraga, Mónica|||0000-0003-4754-311X
Salgueiriño, Verónica
author_role author
author2 Hurtado, Pablo
Dávila-Ibáñez, Ana B
Piñeiro, Roberto
López Fanarraga, Mónica|||0000-0003-4754-311X
Salgueiriño, Verónica
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad de Cantabria
dc.subject.none.fl_str_mv Magnetic swimmers
Magnetophoretic mobility
Viscosity
Zebrafish yolk sac
topic Magnetic swimmers
Magnetophoretic mobility
Viscosity
Zebrafish yolk sac
description Elongated nanostructures to be remotely and magnetically propelled in biologically relevant media, have gained attention as offering themselves as effective tools or carriers in theragnostics applications. However, the magnetic actuation associated remains challenging due to the lack of mechanical information in the media of interest, taking into account biophysical or biomedical purposes. In this study, we detail the magnetic actuation of magnetically propelled chained nanocomposites considering their dynamics, in which their velocity can be modulated in terms of the viscosity of the medium considered, given a magnetic field gradient. Simpler cases of distilled water, a water/glycerol mixture and a fluid made of cell extracts (imitating the cytosol of cells) of known viscosity are the basis experiments for the study of more complex media inside HeLa cells, murine NIH-3T3 fibroblasts and zebrafish larvae, offering the mechanical information required. The experimental results indicate that the magnetically propelled performance of the chained nanostructures can be precisely controlled in potentially changing scenarios, where drug and heat delivery, magnetic separation, or microfluidic technologies are demanded, using a magnetic field gradient and providing good estimations of the dynamical parameters involved.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10902/26552
url https://hdl.handle.net/10902/26552
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv J Colloid Interface Sci . Volume 629, Part A, January 2023, Pages 287-296
reponame:UCrea Repositorio Abierto de la Universidad de Cantabria
instname:Universidad de Cantabria (UC)
instname_str Universidad de Cantabria (UC)
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
collection UCrea Repositorio Abierto de la Universidad de Cantabria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301629

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