Incidence and mortality of nonmelanoma skin cancer in Europe: current trends and challenges

Purpose: Nonmelanoma skin cancer (NMSC), predominantly basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), represents the most common malignancy among fair-skinned populations. While BCC is rarely fatal, SCC contributes significantly to NMSC-related mortality. This study aimed to investiga...

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Autores: Sendín Martín, Mercedes, Bueno Molina, Rocío C., Hernández Rodríguez, Juan Carlos, Cayuela, Lucía, Cayuela, Aurelio, Pereyra-Rodríguez, José-Juan
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/175457
Acceso en línea:https://hdl.handle.net/11441/175457
https://doi.org/10.1007/s12094-025-03985-z
Access Level:acceso abierto
Palabra clave:non melanoma skin cáncer
basal cell carcinoma
squamous cell carcinoma
incidence
mortality
Europe
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spelling Incidence and mortality of nonmelanoma skin cancer in Europe: current trends and challengesSendín Martín, MercedesBueno Molina, Rocío C.Hernández Rodríguez, Juan CarlosCayuela, LucíaCayuela, AurelioPereyra-Rodríguez, José-Juannon melanoma skin cáncerbasal cell carcinomasquamous cell carcinomaincidencemortalityEuropePurpose: Nonmelanoma skin cancer (NMSC), predominantly basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), represents the most common malignancy among fair-skinned populations. While BCC is rarely fatal, SCC contributes significantly to NMSC-related mortality. This study aimed to investigate long-term trends in NMSC incidence and SCC mortality across 28 European countries from 1992 to 2021, focusing on regional, sex-specific, and age-related variations. Methods/patients: A longitudinal ecological analysis was conducted using the Global Burden of Disease (GBD) database. Age-standardized incidence rates (ASIRs) for NMSC and age-standardized mortality rates (ASMRs) for SCC were calculated based on the 2013 European Standard Population. Temporal trends were evaluated using joinpoint regression, and age–period–cohort (APC) models were employed to disentangle independent effects on SCC mortality. Results: Europe registered over 27 million NMSC cases between 1992 and 2021. Overall ASIRs slightly declined, although increasing incidence was observed in individuals under 45 in Central and Northern Europe. SCC accounted for more than 570,000 deaths, with overall ASMRs decreasing—particularly among women and younger men. However, mortality rose in men aged over 75, notably in Northern and Western Europe. APC analysis indicated elevated SCC mortality in cohorts born before 1940, with a notable reversal in Northern European males born after 1960, who exhibited increasing mortality. Period effects further confirmed a recent rise in SCC mortality among these populations. Conclusions: Although NMSC incidence appears to be stabilizing or declining in much of Europe, increasing trends in younger individuals and rising SCC mortality in older men—especially in Northern Europe—highlight the need for age- and region-specific prevention and screening strategies. Improved cancer registry harmonization remains essential for guiding effective public health interventions.SpringerMedicina2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/175457https://doi.org/10.1007/s12094-025-03985-zreponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésClinical and Translational Oncology, 28 (1), 302-319. https://link.springer.com/article/10.1007/s12094-025-03985-zinfo:eu-repo/semantics/openAccessoai:idus.us.es:11441/1754572026-06-17T12:51:07Z
dc.title.none.fl_str_mv Incidence and mortality of nonmelanoma skin cancer in Europe: current trends and challenges
title Incidence and mortality of nonmelanoma skin cancer in Europe: current trends and challenges
spellingShingle Incidence and mortality of nonmelanoma skin cancer in Europe: current trends and challenges
Sendín Martín, Mercedes
non melanoma skin cáncer
basal cell carcinoma
squamous cell carcinoma
incidence
mortality
Europe
title_short Incidence and mortality of nonmelanoma skin cancer in Europe: current trends and challenges
title_full Incidence and mortality of nonmelanoma skin cancer in Europe: current trends and challenges
title_fullStr Incidence and mortality of nonmelanoma skin cancer in Europe: current trends and challenges
title_full_unstemmed Incidence and mortality of nonmelanoma skin cancer in Europe: current trends and challenges
title_sort Incidence and mortality of nonmelanoma skin cancer in Europe: current trends and challenges
dc.creator.none.fl_str_mv Sendín Martín, Mercedes
Bueno Molina, Rocío C.
Hernández Rodríguez, Juan Carlos
Cayuela, Lucía
Cayuela, Aurelio
Pereyra-Rodríguez, José-Juan
author Sendín Martín, Mercedes
author_facet Sendín Martín, Mercedes
Bueno Molina, Rocío C.
Hernández Rodríguez, Juan Carlos
Cayuela, Lucía
Cayuela, Aurelio
Pereyra-Rodríguez, José-Juan
author_role author
author2 Bueno Molina, Rocío C.
Hernández Rodríguez, Juan Carlos
Cayuela, Lucía
Cayuela, Aurelio
Pereyra-Rodríguez, José-Juan
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Medicina
dc.subject.none.fl_str_mv non melanoma skin cáncer
basal cell carcinoma
squamous cell carcinoma
incidence
mortality
Europe
topic non melanoma skin cáncer
basal cell carcinoma
squamous cell carcinoma
incidence
mortality
Europe
description Purpose: Nonmelanoma skin cancer (NMSC), predominantly basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), represents the most common malignancy among fair-skinned populations. While BCC is rarely fatal, SCC contributes significantly to NMSC-related mortality. This study aimed to investigate long-term trends in NMSC incidence and SCC mortality across 28 European countries from 1992 to 2021, focusing on regional, sex-specific, and age-related variations. Methods/patients: A longitudinal ecological analysis was conducted using the Global Burden of Disease (GBD) database. Age-standardized incidence rates (ASIRs) for NMSC and age-standardized mortality rates (ASMRs) for SCC were calculated based on the 2013 European Standard Population. Temporal trends were evaluated using joinpoint regression, and age–period–cohort (APC) models were employed to disentangle independent effects on SCC mortality. Results: Europe registered over 27 million NMSC cases between 1992 and 2021. Overall ASIRs slightly declined, although increasing incidence was observed in individuals under 45 in Central and Northern Europe. SCC accounted for more than 570,000 deaths, with overall ASMRs decreasing—particularly among women and younger men. However, mortality rose in men aged over 75, notably in Northern and Western Europe. APC analysis indicated elevated SCC mortality in cohorts born before 1940, with a notable reversal in Northern European males born after 1960, who exhibited increasing mortality. Period effects further confirmed a recent rise in SCC mortality among these populations. Conclusions: Although NMSC incidence appears to be stabilizing or declining in much of Europe, increasing trends in younger individuals and rising SCC mortality in older men—especially in Northern Europe—highlight the need for age- and region-specific prevention and screening strategies. Improved cancer registry harmonization remains essential for guiding effective public health interventions.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/175457
https://doi.org/10.1007/s12094-025-03985-z
url https://hdl.handle.net/11441/175457
https://doi.org/10.1007/s12094-025-03985-z
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Clinical and Translational Oncology, 28 (1), 302-319.
https://link.springer.com/article/10.1007/s12094-025-03985-z
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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