Exploring the Associations of Inflammatory and Oxidative Stress Biomarkers with Pancreatic Diseases: An Observational and Mendelian Randomisation Study

Identifying biomarkers linked to pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP) is crucial for early detection, treatment, and prevention. Methods: Association analyses of 10 serological biomarkers involved in cell signalling (IFN-gamma, IL-6, IL-8, IL-10), oxidative stress (s...

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Autores: Vilà Quintana, Laura, Fort, Esther, Pardo, Laura, Albiol Quer, Maria T., Ortiz, Maria Rosa, Capdevila, Montserrat, Feliu, Anna, Bahí, Anna, Llirós, Marc, Aguilar, Esther, García Velasco, Adelaida, Ginestà, Mireia M., Laquente, Berta, Pozas, Débora, Lluansí, Aleix, Pimenoff, Ville Nikolai, Moreno Aguado, Víctor, Garcia Gil, Libadro Jesús, Duell, Eric J., Carreras Torres, Robert, Aldeguer, Xavier
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/214407
Acesso em linha:https://hdl.handle.net/2445/214407
Access Level:acceso abierto
Palavra-chave:Pancreatitis
Estrès oxidatiu
Marcadors bioquímics
Oxidative stress
Biochemical markers
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spelling Exploring the Associations of Inflammatory and Oxidative Stress Biomarkers with Pancreatic Diseases: An Observational and Mendelian Randomisation StudyVilà Quintana, LauraFort, EstherPardo, LauraAlbiol Quer, Maria T.Ortiz, Maria RosaCapdevila, MontserratFeliu, AnnaBahí, AnnaLlirós, MarcAguilar, EstherGarcía Velasco, AdelaidaGinestà, Mireia M.Laquente, BertaPozas, DéboraLluansí, AleixPimenoff, Ville NikolaiMoreno Aguado, VíctorGarcia Gil, Libadro JesúsDuell, Eric J.Carreras Torres, RobertAldeguer, XavierPancreatitisEstrès oxidatiuMarcadors bioquímicsPancreatitisOxidative stressBiochemical markersIdentifying biomarkers linked to pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP) is crucial for early detection, treatment, and prevention. Methods: Association analyses of 10 serological biomarkers involved in cell signalling (IFN-gamma, IL-6, IL-8, IL-10), oxidative stress (superoxide dismutase (SOD) and glutathione peroxidase (GPx) enzyme activities, total glutathione (GSH), malondialdehyde (MDA) levels), and intestinal permeability proteins (zonulin, I-FABP2) were conducted across PDAC (n = 12), CP (n = 21) and control subjects (n = 23). A Mendelian randomisation (MR) approach was used to assess causality of the identified significant associations in two large genetic cohorts (FinnGen and UK Biobank). Results: Observational results showed a downregulation of SOD and GPx antioxidant enzyme activities in PDAC and CP patients, respectively, and higher MDA levels in CP patients. Logistic regression models revealed significant associations between CP and SOD activity (OR = 0.21, 95% CI [0.05, 0.89], per SD), GPx activity (OR = 0.28, 95% CI [0.10, 0.79], per SD), and MDA levels (OR = 2.05, 95% CI [1.36, 3.08], per SD). MR analyses, however, did not support causality. Conclusions: These findings would not support oxidative stress-related biomarkers as potential targets for pancreatic diseases prevention. Yet, further research is encouraged to assess their viability as non-invasive tools for early diagnosis, particularly in pre-diagnostic CP populations.MDPI AG2024202420242024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion12 p.application/pdfhttps://hdl.handle.net/2445/214407Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/jcm13082247Journal of Clinical Medicine, 2024, vol. 13, num. 8, p. 2247https://doi.org/10.3390/jcm13082247cc by (c) Vilà Quintana, Laura et al., 2024http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2144072026-05-29T05:05:01Z
dc.title.none.fl_str_mv Exploring the Associations of Inflammatory and Oxidative Stress Biomarkers with Pancreatic Diseases: An Observational and Mendelian Randomisation Study
title Exploring the Associations of Inflammatory and Oxidative Stress Biomarkers with Pancreatic Diseases: An Observational and Mendelian Randomisation Study
spellingShingle Exploring the Associations of Inflammatory and Oxidative Stress Biomarkers with Pancreatic Diseases: An Observational and Mendelian Randomisation Study
Vilà Quintana, Laura
Pancreatitis
Estrès oxidatiu
Marcadors bioquímics
Pancreatitis
Oxidative stress
Biochemical markers
title_short Exploring the Associations of Inflammatory and Oxidative Stress Biomarkers with Pancreatic Diseases: An Observational and Mendelian Randomisation Study
title_full Exploring the Associations of Inflammatory and Oxidative Stress Biomarkers with Pancreatic Diseases: An Observational and Mendelian Randomisation Study
title_fullStr Exploring the Associations of Inflammatory and Oxidative Stress Biomarkers with Pancreatic Diseases: An Observational and Mendelian Randomisation Study
title_full_unstemmed Exploring the Associations of Inflammatory and Oxidative Stress Biomarkers with Pancreatic Diseases: An Observational and Mendelian Randomisation Study
title_sort Exploring the Associations of Inflammatory and Oxidative Stress Biomarkers with Pancreatic Diseases: An Observational and Mendelian Randomisation Study
dc.creator.none.fl_str_mv Vilà Quintana, Laura
Fort, Esther
Pardo, Laura
Albiol Quer, Maria T.
Ortiz, Maria Rosa
Capdevila, Montserrat
Feliu, Anna
Bahí, Anna
Llirós, Marc
Aguilar, Esther
García Velasco, Adelaida
Ginestà, Mireia M.
Laquente, Berta
Pozas, Débora
Lluansí, Aleix
Pimenoff, Ville Nikolai
Moreno Aguado, Víctor
Garcia Gil, Libadro Jesús
Duell, Eric J.
Carreras Torres, Robert
Aldeguer, Xavier
author Vilà Quintana, Laura
author_facet Vilà Quintana, Laura
Fort, Esther
Pardo, Laura
Albiol Quer, Maria T.
Ortiz, Maria Rosa
Capdevila, Montserrat
Feliu, Anna
Bahí, Anna
Llirós, Marc
Aguilar, Esther
García Velasco, Adelaida
Ginestà, Mireia M.
Laquente, Berta
Pozas, Débora
Lluansí, Aleix
Pimenoff, Ville Nikolai
Moreno Aguado, Víctor
Garcia Gil, Libadro Jesús
Duell, Eric J.
Carreras Torres, Robert
Aldeguer, Xavier
author_role author
author2 Fort, Esther
Pardo, Laura
Albiol Quer, Maria T.
Ortiz, Maria Rosa
Capdevila, Montserrat
Feliu, Anna
Bahí, Anna
Llirós, Marc
Aguilar, Esther
García Velasco, Adelaida
Ginestà, Mireia M.
Laquente, Berta
Pozas, Débora
Lluansí, Aleix
Pimenoff, Ville Nikolai
Moreno Aguado, Víctor
Garcia Gil, Libadro Jesús
Duell, Eric J.
Carreras Torres, Robert
Aldeguer, Xavier
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Pancreatitis
Estrès oxidatiu
Marcadors bioquímics
Pancreatitis
Oxidative stress
Biochemical markers
topic Pancreatitis
Estrès oxidatiu
Marcadors bioquímics
Pancreatitis
Oxidative stress
Biochemical markers
description Identifying biomarkers linked to pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP) is crucial for early detection, treatment, and prevention. Methods: Association analyses of 10 serological biomarkers involved in cell signalling (IFN-gamma, IL-6, IL-8, IL-10), oxidative stress (superoxide dismutase (SOD) and glutathione peroxidase (GPx) enzyme activities, total glutathione (GSH), malondialdehyde (MDA) levels), and intestinal permeability proteins (zonulin, I-FABP2) were conducted across PDAC (n = 12), CP (n = 21) and control subjects (n = 23). A Mendelian randomisation (MR) approach was used to assess causality of the identified significant associations in two large genetic cohorts (FinnGen and UK Biobank). Results: Observational results showed a downregulation of SOD and GPx antioxidant enzyme activities in PDAC and CP patients, respectively, and higher MDA levels in CP patients. Logistic regression models revealed significant associations between CP and SOD activity (OR = 0.21, 95% CI [0.05, 0.89], per SD), GPx activity (OR = 0.28, 95% CI [0.10, 0.79], per SD), and MDA levels (OR = 2.05, 95% CI [1.36, 3.08], per SD). MR analyses, however, did not support causality. Conclusions: These findings would not support oxidative stress-related biomarkers as potential targets for pancreatic diseases prevention. Yet, further research is encouraged to assess their viability as non-invasive tools for early diagnosis, particularly in pre-diagnostic CP populations.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/214407
url https://hdl.handle.net/2445/214407
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/jcm13082247
Journal of Clinical Medicine, 2024, vol. 13, num. 8, p. 2247
https://doi.org/10.3390/jcm13082247
dc.rights.none.fl_str_mv cc by (c) Vilà Quintana, Laura et al., 2024
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Vilà Quintana, Laura et al., 2024
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 12 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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