Exploring the Associations of Inflammatory and Oxidative Stress Biomarkers with Pancreatic Diseases: An Observational and Mendelian Randomisation Study

Identifying biomarkers linked to pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP) is crucial for early detection, treatment, and prevention. Methods: Association analyses of 10 serological biomarkers involved in cell signalling (IFN-γ, IL-6, IL-8, IL-10), oxidative stress (super...

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Detalhes bibliográficos
Autores: Vilà-Quintana, Laura, Fort Martorell, Esther, Pardo, Laura, Albiol Quer, Maite, Ortiz Duran, Maria Rosa, Capdevila, Montserrat, Feliu, Anna, Bahí, Anna, Llirós Dupré, Marc, Aguilar, Esther, García Velasco, Adelaida, Ginestà, Mireia M., Laquente, Berta, Pozas, Débora, Lluansí Salis, Aleix, Pimenoff, Ville Nikolai, Moreno Aguado, Víctor, Garcia-Gil, L. J., Duell, Eric J., Carreras-Torres, Robert, Aldeguer i Manté, Xavier
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10256/25214
Acesso em linha:http://hdl.handle.net/10256/25214
Access Level:acceso abierto
Palavra-chave:Adenocarcinoma
Pancreatitis
Pàncrees -- Malalties
Pancreas -- Diseases
Estrès oxidatiu
Oxidative stress
Marcadors tumorals
Tumor markers
Descrição
Resumo:Identifying biomarkers linked to pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP) is crucial for early detection, treatment, and prevention. Methods: Association analyses of 10 serological biomarkers involved in cell signalling (IFN-γ, IL-6, IL-8, IL-10), oxidative stress (superoxide dismutase (SOD) and glutathione peroxidase (GPx) enzyme activities, total glutathione (GSH), malondialdehyde (MDA) levels), and intestinal permeability proteins (zonulin, I-FABP2) were conducted across PDAC (n = 12), CP (n = 21) and control subjects (n = 23). A Mendelian randomisation (MR) approach was used to assess causality of the identified significant associations in two large genetic cohorts (FinnGen and UK Biobank). Results: Observational results showed a downregulation of SOD and GPx antioxidant enzyme activities in PDAC and CP patients, respectively, and higher MDA levels in CP patients. Logistic regression models revealed significant associations between CP and SOD activity (OR = 0.21, 95% CI [0.05, 0.89], per SD), GPx activity (OR = 0.28, 95% CI [0.10, 0.79], per SD), and MDA levels (OR = 2.05, 95% CI [1.36, 3.08], per SD). MR analyses, however, did not support causality. Conclusions: These findings would not support oxidative stress-related biomarkers as potential targets for pancreatic diseases prevention. Yet, further research is encouraged to assess their viability as non-invasive tools for early diagnosis, particularly in pre-diagnostic CP populations

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