Tratamiento de la cirrosis biliar primaria con ácido ursodesoxicólico. Resultados a corto y medio plazo y relación con el estudio de la enfermedad
We present the results of the treatment with ursodeoxycholic acid (UDCA, 7-9 mg/kg body weight daily) of 17 patients with primary biliary cirrhosis (8 in stages I-II; 9 in stages III-IV). At two months the mean values of alkaline phosphatase, gammaglutamiltranspeptidase, alanine and aspartate aminot...
| Autores: | , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 1991 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | español |
| OAI Identifier: | oai:dadun.unav.edu:10171/29581 |
| Acceso en línea: | https://hdl.handle.net/10171/29581 |
| Access Level: | acceso abierto |
| Palabra clave: | Ursodeoxycholic acid Primary biliary Cirrhosis Pruritus Bilirubin Hepatología |
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Tratamiento de la cirrosis biliar primaria con ácido ursodesoxicólico. Resultados a corto y medio plazo y relación con el estudio de la enfermedadGarcia-Villarreal, L. (Luis)|||/items/397c8983-3fdb-45d3-9d5b-20b34f79cc6aZozaya, J.M. (José Manuel)|||/items/70a8a1ed-51c0-4166-9547-ecde1a29e8a1Garcia, N. (Nicolás)|||/items/f28987d6-9dc4-4d34-9f80-436b9bddb930Quiroga, J. (Jorge)|||/items/580a0a4e-16a6-446c-840c-3e225592fa4bConchillo, F. (F.)|||/items/2a1de8bb-19db-4237-9a64-663ae7d0ac1fPrieto, J. (Jesús)|||/items/0d9c3dec-4a09-400d-8c83-23ece1096c71Macias, E. (Elena)|||/items/9863e1dd-16aa-4e7b-81aa-5c84fedca0d8Ursodeoxycholic acidPrimary biliaryCirrhosisPruritusBilirubinHepatologíaWe present the results of the treatment with ursodeoxycholic acid (UDCA, 7-9 mg/kg body weight daily) of 17 patients with primary biliary cirrhosis (8 in stages I-II; 9 in stages III-IV). At two months the mean values of alkaline phosphatase, gammaglutamiltranspeptidase, alanine and aspartate aminotransferase were reduced (p less than 0.001, p less than 0.001, p less than 0.01 and p less than 0.01 respectively). This improvement persisted without increase during the first year. At two months the total bilirubin value was reduced (p less than 0.01) associated with a reduction in the conjugated fraction (p less than 0.05). Cholesterol and gammaglobulin mean values also decreased at two months (p less than 0.05). We found no changes in IgM levels and antimitochondrial antibody titers. The improvement was similar in both groups (early I-II and advanced III-IV stages) and the treatment showed no undesirable effects either in early or advanced stages. Almost all the patients with pruritus (6 out of 7) improved with the treatment and the use of cholestyramine was reduced in allThe Spanish Society of Digestive PathologyDadun. Depósito Académico Digital Universidad de Navarra20132013-08-1719911991-01-0119911991-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/29581reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraEspañolspaopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/295812026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Tratamiento de la cirrosis biliar primaria con ácido ursodesoxicólico. Resultados a corto y medio plazo y relación con el estudio de la enfermedad |
| title |
Tratamiento de la cirrosis biliar primaria con ácido ursodesoxicólico. Resultados a corto y medio plazo y relación con el estudio de la enfermedad |
| spellingShingle |
Tratamiento de la cirrosis biliar primaria con ácido ursodesoxicólico. Resultados a corto y medio plazo y relación con el estudio de la enfermedad Garcia-Villarreal, L. (Luis)|||/items/397c8983-3fdb-45d3-9d5b-20b34f79cc6a Ursodeoxycholic acid Primary biliary Cirrhosis Pruritus Bilirubin Hepatología |
| title_short |
Tratamiento de la cirrosis biliar primaria con ácido ursodesoxicólico. Resultados a corto y medio plazo y relación con el estudio de la enfermedad |
| title_full |
Tratamiento de la cirrosis biliar primaria con ácido ursodesoxicólico. Resultados a corto y medio plazo y relación con el estudio de la enfermedad |
| title_fullStr |
Tratamiento de la cirrosis biliar primaria con ácido ursodesoxicólico. Resultados a corto y medio plazo y relación con el estudio de la enfermedad |
| title_full_unstemmed |
Tratamiento de la cirrosis biliar primaria con ácido ursodesoxicólico. Resultados a corto y medio plazo y relación con el estudio de la enfermedad |
| title_sort |
Tratamiento de la cirrosis biliar primaria con ácido ursodesoxicólico. Resultados a corto y medio plazo y relación con el estudio de la enfermedad |
| dc.creator.none.fl_str_mv |
Garcia-Villarreal, L. (Luis)|||/items/397c8983-3fdb-45d3-9d5b-20b34f79cc6a Zozaya, J.M. (José Manuel)|||/items/70a8a1ed-51c0-4166-9547-ecde1a29e8a1 Garcia, N. (Nicolás)|||/items/f28987d6-9dc4-4d34-9f80-436b9bddb930 Quiroga, J. (Jorge)|||/items/580a0a4e-16a6-446c-840c-3e225592fa4b Conchillo, F. (F.)|||/items/2a1de8bb-19db-4237-9a64-663ae7d0ac1f Prieto, J. (Jesús)|||/items/0d9c3dec-4a09-400d-8c83-23ece1096c71 Macias, E. (Elena)|||/items/9863e1dd-16aa-4e7b-81aa-5c84fedca0d8 |
| author |
Garcia-Villarreal, L. (Luis)|||/items/397c8983-3fdb-45d3-9d5b-20b34f79cc6a |
| author_facet |
Garcia-Villarreal, L. (Luis)|||/items/397c8983-3fdb-45d3-9d5b-20b34f79cc6a Zozaya, J.M. (José Manuel)|||/items/70a8a1ed-51c0-4166-9547-ecde1a29e8a1 Garcia, N. (Nicolás)|||/items/f28987d6-9dc4-4d34-9f80-436b9bddb930 Quiroga, J. (Jorge)|||/items/580a0a4e-16a6-446c-840c-3e225592fa4b Conchillo, F. (F.)|||/items/2a1de8bb-19db-4237-9a64-663ae7d0ac1f Prieto, J. (Jesús)|||/items/0d9c3dec-4a09-400d-8c83-23ece1096c71 Macias, E. (Elena)|||/items/9863e1dd-16aa-4e7b-81aa-5c84fedca0d8 |
| author_role |
author |
| author2 |
Zozaya, J.M. (José Manuel)|||/items/70a8a1ed-51c0-4166-9547-ecde1a29e8a1 Garcia, N. (Nicolás)|||/items/f28987d6-9dc4-4d34-9f80-436b9bddb930 Quiroga, J. (Jorge)|||/items/580a0a4e-16a6-446c-840c-3e225592fa4b Conchillo, F. (F.)|||/items/2a1de8bb-19db-4237-9a64-663ae7d0ac1f Prieto, J. (Jesús)|||/items/0d9c3dec-4a09-400d-8c83-23ece1096c71 Macias, E. (Elena)|||/items/9863e1dd-16aa-4e7b-81aa-5c84fedca0d8 |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Ursodeoxycholic acid Primary biliary Cirrhosis Pruritus Bilirubin Hepatología |
| topic |
Ursodeoxycholic acid Primary biliary Cirrhosis Pruritus Bilirubin Hepatología |
| description |
We present the results of the treatment with ursodeoxycholic acid (UDCA, 7-9 mg/kg body weight daily) of 17 patients with primary biliary cirrhosis (8 in stages I-II; 9 in stages III-IV). At two months the mean values of alkaline phosphatase, gammaglutamiltranspeptidase, alanine and aspartate aminotransferase were reduced (p less than 0.001, p less than 0.001, p less than 0.01 and p less than 0.01 respectively). This improvement persisted without increase during the first year. At two months the total bilirubin value was reduced (p less than 0.01) associated with a reduction in the conjugated fraction (p less than 0.05). Cholesterol and gammaglobulin mean values also decreased at two months (p less than 0.05). We found no changes in IgM levels and antimitochondrial antibody titers. The improvement was similar in both groups (early I-II and advanced III-IV stages) and the treatment showed no undesirable effects either in early or advanced stages. Almost all the patients with pruritus (6 out of 7) improved with the treatment and the use of cholestyramine was reduced in all |
| publishDate |
1991 |
| dc.date.none.fl_str_mv |
1991 1991-01-01 1991 1991-01-01 2013 2013-08-17 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/29581 |
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https://hdl.handle.net/10171/29581 |
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Español spa |
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Español |
| language |
spa |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
The Spanish Society of Digestive Pathology |
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The Spanish Society of Digestive Pathology |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
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Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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1869413082045874176 |
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15,301603 |