Tratamiento de la cirrosis biliar primaria con ácido ursodesoxicólico. Resultados a corto y medio plazo y relación con el estudio de la enfermedad

We present the results of the treatment with ursodeoxycholic acid (UDCA, 7-9 mg/kg body weight daily) of 17 patients with primary biliary cirrhosis (8 in stages I-II; 9 in stages III-IV). At two months the mean values of alkaline phosphatase, gammaglutamiltranspeptidase, alanine and aspartate aminot...

Descripción completa

Detalles Bibliográficos
Autores: Garcia-Villarreal, L. (Luis)|||/items/397c8983-3fdb-45d3-9d5b-20b34f79cc6a, Zozaya, J.M. (José Manuel)|||/items/70a8a1ed-51c0-4166-9547-ecde1a29e8a1, Garcia, N. (Nicolás)|||/items/f28987d6-9dc4-4d34-9f80-436b9bddb930, Quiroga, J. (Jorge)|||/items/580a0a4e-16a6-446c-840c-3e225592fa4b, Conchillo, F. (F.)|||/items/2a1de8bb-19db-4237-9a64-663ae7d0ac1f, Prieto, J. (Jesús)|||/items/0d9c3dec-4a09-400d-8c83-23ece1096c71, Macias, E. (Elena)|||/items/9863e1dd-16aa-4e7b-81aa-5c84fedca0d8
Tipo de recurso: artículo
Fecha de publicación:1991
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:español
OAI Identifier:oai:dadun.unav.edu:10171/29581
Acceso en línea:https://hdl.handle.net/10171/29581
Access Level:acceso abierto
Palabra clave:Ursodeoxycholic acid
Primary biliary
Cirrhosis
Pruritus
Bilirubin
Hepatología
Descripción
Sumario:We present the results of the treatment with ursodeoxycholic acid (UDCA, 7-9 mg/kg body weight daily) of 17 patients with primary biliary cirrhosis (8 in stages I-II; 9 in stages III-IV). At two months the mean values of alkaline phosphatase, gammaglutamiltranspeptidase, alanine and aspartate aminotransferase were reduced (p less than 0.001, p less than 0.001, p less than 0.01 and p less than 0.01 respectively). This improvement persisted without increase during the first year. At two months the total bilirubin value was reduced (p less than 0.01) associated with a reduction in the conjugated fraction (p less than 0.05). Cholesterol and gammaglobulin mean values also decreased at two months (p less than 0.05). We found no changes in IgM levels and antimitochondrial antibody titers. The improvement was similar in both groups (early I-II and advanced III-IV stages) and the treatment showed no undesirable effects either in early or advanced stages. Almost all the patients with pruritus (6 out of 7) improved with the treatment and the use of cholestyramine was reduced in all

Similares en LA Referencia