Emotional and cognitive effects of menopause and hormone replacement therapy

[Background] Menopause is a natural physiological process, but its effects on the brain remain poorly understood. In England, approximately 15% of women use hormone-replacement therapy (HRT) to manage menopausal symptoms. However, the psychological benefits of HRT are not well established. This stud...

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Bibliographic Details
Authors: Zuhlsdorff, Katharina, Langley, Christelle, Bethlehem, Richard, Warrier, Varun, Romero García, Rafael, Sahakian, Barbara J.
Format: article
Status:Published version
Publication Date:2026
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/422413
Online Access:http://hdl.handle.net/10261/422413
https://api.elsevier.com/content/abstract/scopus_id/105028662587
Access Level:Open access
Keyword:Anterior cingulate cortex
Cognition
Entorhinal cortex
Hippocampus
Hormone replacement therapy
Menopause
Mental health
Description
Summary:[Background] Menopause is a natural physiological process, but its effects on the brain remain poorly understood. In England, approximately 15% of women use hormone-replacement therapy (HRT) to manage menopausal symptoms. However, the psychological benefits of HRT are not well established. This study aims to investigate the impact of menopause and HRT on mental health, cognitive function, and brain structure.