Mechanosensitive Ion Channels: Their Physiological Importance and Potential Key Role in Cancer

Mechanosensitive ion channels comprise a broad group of proteins that sense mechanical extracellular and intracellular changes, translating them into cation influx to adapt and respond to these physical cues. All cells in the organism are mechanosensitive, and these physical cues have proven to have...

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Detalles Bibliográficos
Autores: Otero Sobrino, Álvaro, Blanco Carlón, Pablo, Navarro Aguadero, Miguel Ángel, Gallardo, Miguel, Martínez López, Joaquín, Velasco Estévez, María
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/106015
Acceso en línea:https://hdl.handle.net/20.500.14352/106015
Access Level:acceso abierto
Palabra clave:61
mechanoreceptors
ion channels
TRP
PIEZO
immunity
cancer
Ciencias Biomédicas
32 Ciencias Médicas
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repository_id_str
spelling Mechanosensitive Ion Channels: Their Physiological Importance and Potential Key Role in CancerOtero Sobrino, ÁlvaroBlanco Carlón, PabloNavarro Aguadero, Miguel ÁngelGallardo, MiguelMartínez López, JoaquínVelasco Estévez, María61mechanoreceptorsion channelsTRPPIEZOimmunitycancerCiencias Biomédicas32 Ciencias MédicasMechanosensitive ion channels comprise a broad group of proteins that sense mechanical extracellular and intracellular changes, translating them into cation influx to adapt and respond to these physical cues. All cells in the organism are mechanosensitive, and these physical cues have proven to have an important role in regulating proliferation, cell fate and differentiation, migration and cellular stress, among other processes. Indeed, the mechanical properties of the extracellular matrix in cancer change drastically due to high cell proliferation and modification of extracellular protein secretion, suggesting an important contribution to tumor cell regulation. In this review, we describe the physiological significance of mechanosensitive ion channels, emphasizing their role in cancer and immunity, and providing compelling proof of the importance of continuing to explore their potential as new therapeutic targets in cancer research.MDPIUniversidad Complutense de Madrid20232023-09-0520232023-09-05journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/106015reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1060152026-06-02T12:44:21Z
dc.title.none.fl_str_mv Mechanosensitive Ion Channels: Their Physiological Importance and Potential Key Role in Cancer
title Mechanosensitive Ion Channels: Their Physiological Importance and Potential Key Role in Cancer
spellingShingle Mechanosensitive Ion Channels: Their Physiological Importance and Potential Key Role in Cancer
Otero Sobrino, Álvaro
61
mechanoreceptors
ion channels
TRP
PIEZO
immunity
cancer
Ciencias Biomédicas
32 Ciencias Médicas
title_short Mechanosensitive Ion Channels: Their Physiological Importance and Potential Key Role in Cancer
title_full Mechanosensitive Ion Channels: Their Physiological Importance and Potential Key Role in Cancer
title_fullStr Mechanosensitive Ion Channels: Their Physiological Importance and Potential Key Role in Cancer
title_full_unstemmed Mechanosensitive Ion Channels: Their Physiological Importance and Potential Key Role in Cancer
title_sort Mechanosensitive Ion Channels: Their Physiological Importance and Potential Key Role in Cancer
dc.creator.none.fl_str_mv Otero Sobrino, Álvaro
Blanco Carlón, Pablo
Navarro Aguadero, Miguel Ángel
Gallardo, Miguel
Martínez López, Joaquín
Velasco Estévez, María
author Otero Sobrino, Álvaro
author_facet Otero Sobrino, Álvaro
Blanco Carlón, Pablo
Navarro Aguadero, Miguel Ángel
Gallardo, Miguel
Martínez López, Joaquín
Velasco Estévez, María
author_role author
author2 Blanco Carlón, Pablo
Navarro Aguadero, Miguel Ángel
Gallardo, Miguel
Martínez López, Joaquín
Velasco Estévez, María
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 61
mechanoreceptors
ion channels
TRP
PIEZO
immunity
cancer
Ciencias Biomédicas
32 Ciencias Médicas
topic 61
mechanoreceptors
ion channels
TRP
PIEZO
immunity
cancer
Ciencias Biomédicas
32 Ciencias Médicas
description Mechanosensitive ion channels comprise a broad group of proteins that sense mechanical extracellular and intracellular changes, translating them into cation influx to adapt and respond to these physical cues. All cells in the organism are mechanosensitive, and these physical cues have proven to have an important role in regulating proliferation, cell fate and differentiation, migration and cellular stress, among other processes. Indeed, the mechanical properties of the extracellular matrix in cancer change drastically due to high cell proliferation and modification of extracellular protein secretion, suggesting an important contribution to tumor cell regulation. In this review, we describe the physiological significance of mechanosensitive ion channels, emphasizing their role in cancer and immunity, and providing compelling proof of the importance of continuing to explore their potential as new therapeutic targets in cancer research.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-09-05
2023
2023-09-05
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/106015
url https://hdl.handle.net/20.500.14352/106015
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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