Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers

[EN]Carbon nanomaterials are widespread in the atmospheric aerosol as a result of the combustion processes and their extensive industrial use. This has raised many question about the potential toxicity associated with the inhalation of such nanoparticles, and its incorporation into the lung surfacta...

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Autores: Muñoz López, Ruth, Guzmán, Eduardo, Velázquez Salicio, María Mercedes, Fernández Peña, Laura, Merchán Moreno, María Dolores, Maestro, Armando, Ortega, Francisco, G. Rubio, Ramón
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Recursos:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/157974
Acesso em linha:http://hdl.handle.net/10366/157974
Access Level:acceso abierto
Palavra-chave:Particles
Lipids
Langmuir monolayer
Lung surfactant
Pollution
Dilational rheology
Toxicity
Carbon nanosheets
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spelling Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir MonolayersMuñoz López, RuthGuzmán, EduardoVelázquez Salicio, María MercedesFernández Peña, LauraMerchán Moreno, María DoloresMaestro, ArmandoOrtega, FranciscoG. Rubio, RamónParticlesLipidsLangmuir monolayerLung surfactantPollutionDilational rheologyToxicityCarbon nanosheets[EN]Carbon nanomaterials are widespread in the atmospheric aerosol as a result of the combustion processes and their extensive industrial use. This has raised many question about the potential toxicity associated with the inhalation of such nanoparticles, and its incorporation into the lung surfactant layer. In order to shed light on the main physical bases underlying the incorporation of carbon nanomaterials into lung surfactant layers, this work has studied the interaction at the water/vapor interface of carbon nanosheets (CN) with Langmuir monolayers of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine (DPPC), with this lipid being the main component of lung surfactant layers and responsible of some of the most relevant features of such film. The incorporation of CN into DPPC Langmuir monolayers modifies the lateral organization of the DPPC at the interface, which is explained on the basis of two di erent e ects: (i) particles occupy part of the interfacial area, and (ii) impoverishment of the lipid composition of the interface due to lipid adsorption onto the CN surface. This results in a worsening of the mechanical performance of the monolayers which may present a negative impact in the physiological performance of lung surfactant. It would be expected that the results obtained here can be useful as a step toward the understanding of the most fundamental physico-chemical bases associated with the e ect of inhaled particles in the respiratory cycle.MDPI202420242020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10366/157974reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)Inglésinfo:eu-repo/semantics/openAccessoai:gredos.usal.es:10366/1579742026-06-07T06:28:51Z
dc.title.none.fl_str_mv Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers
title Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers
spellingShingle Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers
Muñoz López, Ruth
Particles
Lipids
Langmuir monolayer
Lung surfactant
Pollution
Dilational rheology
Toxicity
Carbon nanosheets
title_short Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers
title_full Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers
title_fullStr Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers
title_full_unstemmed Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers
title_sort Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers
dc.creator.none.fl_str_mv Muñoz López, Ruth
Guzmán, Eduardo
Velázquez Salicio, María Mercedes
Fernández Peña, Laura
Merchán Moreno, María Dolores
Maestro, Armando
Ortega, Francisco
G. Rubio, Ramón
author Muñoz López, Ruth
author_facet Muñoz López, Ruth
Guzmán, Eduardo
Velázquez Salicio, María Mercedes
Fernández Peña, Laura
Merchán Moreno, María Dolores
Maestro, Armando
Ortega, Francisco
G. Rubio, Ramón
author_role author
author2 Guzmán, Eduardo
Velázquez Salicio, María Mercedes
Fernández Peña, Laura
Merchán Moreno, María Dolores
Maestro, Armando
Ortega, Francisco
G. Rubio, Ramón
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Particles
Lipids
Langmuir monolayer
Lung surfactant
Pollution
Dilational rheology
Toxicity
Carbon nanosheets
topic Particles
Lipids
Langmuir monolayer
Lung surfactant
Pollution
Dilational rheology
Toxicity
Carbon nanosheets
description [EN]Carbon nanomaterials are widespread in the atmospheric aerosol as a result of the combustion processes and their extensive industrial use. This has raised many question about the potential toxicity associated with the inhalation of such nanoparticles, and its incorporation into the lung surfactant layer. In order to shed light on the main physical bases underlying the incorporation of carbon nanomaterials into lung surfactant layers, this work has studied the interaction at the water/vapor interface of carbon nanosheets (CN) with Langmuir monolayers of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine (DPPC), with this lipid being the main component of lung surfactant layers and responsible of some of the most relevant features of such film. The incorporation of CN into DPPC Langmuir monolayers modifies the lateral organization of the DPPC at the interface, which is explained on the basis of two di erent e ects: (i) particles occupy part of the interfacial area, and (ii) impoverishment of the lipid composition of the interface due to lipid adsorption onto the CN surface. This results in a worsening of the mechanical performance of the monolayers which may present a negative impact in the physiological performance of lung surfactant. It would be expected that the results obtained here can be useful as a step toward the understanding of the most fundamental physico-chemical bases associated with the e ect of inhaled particles in the respiratory cycle.
publishDate 2020
dc.date.none.fl_str_mv 2020
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10366/157974
url http://hdl.handle.net/10366/157974
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname:Universidad de Salamanca (USAL)
instname_str Universidad de Salamanca (USAL)
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
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