Hippo signalling pathway mediates oncogenic properties of NAB2::STAT6 in solitary fibrous tumour

[Purpose] Solitary fibrous tumour (SFT) is a rare mesenchymal neoplasm molecularly defined by the NAB2::STAT6 gene fusion (GF), an aberrant transcriptional regulator whose functions beyond EGR1 activation remain incompletely understood. This study aimed to further elucidate the oncogenic role of NAB...

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Detalles Bibliográficos
Autores: Salguero-Aranda, Carmen, Lobo Selma, Laura, Beltrán-Povea, Amparo, Baute-González, Sergio, Gilabert-Prieto, Paula, Jordán-Pérez, Carmen, Fernández-Juárez, José Alberto, Amaral, Ana Teresa, Rodríguez, René, Díaz-Martín, Juan, Álava, Enrique de
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2026
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/423382
Acceso en línea:http://hdl.handle.net/10261/423382
https://api.elsevier.com/content/abstract/scopus_id/105029780000
Access Level:acceso abierto
Palabra clave:Solitary fibrous tumour
Gene fusion
NAB2:STAT6
Hippo signalling pathway
Dasatinib
Descripción
Sumario:[Purpose] Solitary fibrous tumour (SFT) is a rare mesenchymal neoplasm molecularly defined by the NAB2::STAT6 gene fusion (GF), an aberrant transcriptional regulator whose functions beyond EGR1 activation remain incompletely understood. This study aimed to further elucidate the oncogenic role of NAB2::STAT6 and to identify potential therapeutic vulnerabilities.