Hippo signalling pathway mediates oncogenic properties of NAB2::STAT6 in solitary fibrous tumour
[Purpose] Solitary fibrous tumour (SFT) is a rare mesenchymal neoplasm molecularly defined by the NAB2::STAT6 gene fusion (GF), an aberrant transcriptional regulator whose functions beyond EGR1 activation remain incompletely understood. This study aimed to further elucidate the oncogenic role of NAB...
| Autores: | , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2026 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/423382 |
| Acceso en línea: | http://hdl.handle.net/10261/423382 https://api.elsevier.com/content/abstract/scopus_id/105029780000 |
| Access Level: | acceso abierto |
| Palabra clave: | Solitary fibrous tumour Gene fusion NAB2:STAT6 Hippo signalling pathway Dasatinib |
| Sumario: | [Purpose] Solitary fibrous tumour (SFT) is a rare mesenchymal neoplasm molecularly defined by the NAB2::STAT6 gene fusion (GF), an aberrant transcriptional regulator whose functions beyond EGR1 activation remain incompletely understood. This study aimed to further elucidate the oncogenic role of NAB2::STAT6 and to identify potential therapeutic vulnerabilities. |
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