GABAergic-astrocyte signaling: A refinement of inhibitory brain networks

Interneurons play a critical role in precise control of network operation. Indeed, higher brain capabilities such as working memory, cognitive flexibility, attention, or social interaction rely on the action of GABAergic interneurons. Evidence from excitatory neurons and synapses has revealed astroc...

Descripción completa

Detalles Bibliográficos
Autores: Mederos, Sara, Perea, Gertrudis
Tipo de recurso: artículo
Estado:Versión enviada para evaluación y publicación
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/205435
Acceso en línea:http://hdl.handle.net/10261/205435
Access Level:acceso abierto
Palabra clave:GABAergic interneurons
Astrocytes
excitation/inhibition balance
gliotransmission
synaptic plasticity
id ES_8c93a150ef63d1f74a3272dfaaa34174
oai_identifier_str oai:digital.csic.es:10261/205435
network_acronym_str ES
network_name_str España
repository_id_str
spelling GABAergic-astrocyte signaling: A refinement of inhibitory brain networksMederos, SaraPerea, GertrudisGABAergic interneuronsAstrocytesexcitation/inhibition balancegliotransmissionsynaptic plasticityInterneurons play a critical role in precise control of network operation. Indeed, higher brain capabilities such as working memory, cognitive flexibility, attention, or social interaction rely on the action of GABAergic interneurons. Evidence from excitatory neurons and synapses has revealed astrocytes as integral elements of synaptic transmission. However, GABAergic interneurons can also engage astrocyte signaling; therefore, it is tempting to speculate about different scenarios where, based on particular interneuron cell type, GABAergic-astrocyte interplay would be involved in diverse outcomes of brain function. In this review, we will highlight current data supporting the existence of dynamic GABAergic-astrocyte communication and its impact on the inhibitory-regulated brain responses, bringing new perspectives on the ways astrocytes might contribute to efficient neuronal coding.The authors are grateful to Dr. C. Sánchez-Puelles and C. GonzálezArias for helpful comments. NB Revisions was used for manuscript editing. This work was supported by the PhD fellowship program (MINECO, BES-2014-067594) to SM; and MINECO grant (BFU2016- 75107-P), and and Cajal Blue Brain Project (Spanish partner of the Blue Brain Project initiative from EPFL) and the European Union Horizon 2020 research and innovation program under grant agreement No. 720270 (Human Brain Project, https://www.humanbrainproject.eu/) to GP.John Wiley & SonsConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2020202020192020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Preprintinfo:eu-repo/semantics/submittedVersionhttp://hdl.handle.net/10261/205435reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2013-47265-Rinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2016-75107-Pinfo:eu-repo/grantAgreement/EC/FP7/720270http://dx.doi.org/10.1002/glia.23644Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2054352026-05-22T06:33:51Z
dc.title.none.fl_str_mv GABAergic-astrocyte signaling: A refinement of inhibitory brain networks
title GABAergic-astrocyte signaling: A refinement of inhibitory brain networks
spellingShingle GABAergic-astrocyte signaling: A refinement of inhibitory brain networks
Mederos, Sara
GABAergic interneurons
Astrocytes
excitation/inhibition balance
gliotransmission
synaptic plasticity
title_short GABAergic-astrocyte signaling: A refinement of inhibitory brain networks
title_full GABAergic-astrocyte signaling: A refinement of inhibitory brain networks
title_fullStr GABAergic-astrocyte signaling: A refinement of inhibitory brain networks
title_full_unstemmed GABAergic-astrocyte signaling: A refinement of inhibitory brain networks
title_sort GABAergic-astrocyte signaling: A refinement of inhibitory brain networks
dc.creator.none.fl_str_mv Mederos, Sara
Perea, Gertrudis
author Mederos, Sara
author_facet Mederos, Sara
Perea, Gertrudis
author_role author
author2 Perea, Gertrudis
author2_role author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv GABAergic interneurons
Astrocytes
excitation/inhibition balance
gliotransmission
synaptic plasticity
topic GABAergic interneurons
Astrocytes
excitation/inhibition balance
gliotransmission
synaptic plasticity
description Interneurons play a critical role in precise control of network operation. Indeed, higher brain capabilities such as working memory, cognitive flexibility, attention, or social interaction rely on the action of GABAergic interneurons. Evidence from excitatory neurons and synapses has revealed astrocytes as integral elements of synaptic transmission. However, GABAergic interneurons can also engage astrocyte signaling; therefore, it is tempting to speculate about different scenarios where, based on particular interneuron cell type, GABAergic-astrocyte interplay would be involved in diverse outcomes of brain function. In this review, we will highlight current data supporting the existence of dynamic GABAergic-astrocyte communication and its impact on the inhibitory-regulated brain responses, bringing new perspectives on the ways astrocytes might contribute to efficient neuronal coding.
publishDate 2019
dc.date.none.fl_str_mv 2019
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Preprint
info:eu-repo/semantics/submittedVersion
format article
status_str submittedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/205435
url http://hdl.handle.net/10261/205435
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2013-47265-R
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2016-75107-P
info:eu-repo/grantAgreement/EC/FP7/720270
http://dx.doi.org/10.1002/glia.23644
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869412944174907392
score 15,812429

Similares en LA Referencia