Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infection

Integrase strand transfer inhibitors (INSTI) are a main component of the current antiretroviral regimens recommended for treatment of HIV infection. However, little is known about the impact of INSTI on neurocognition and neuroimaging. We developed a prospective observational trial to evaluate the e...

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Autores: Prats París, Anna, Martínez Zalacaín, Ignacio, Mothe, Beatriz|||0000-0001-9975-407X, Negredo Puigmal, Eugènia, Pérez Álvarez, Nuria|||0000-0001-6582-1553, Garolera, Maite, Domènech Puigcerver, Sira, Coll, Pep, Meulbroek, M., Chamorro, Anna, Rodriguez Fumaz, Carmina, Ferrer, Maria, Clotet Sala, Bonaventura, Soriano Mas, Carles, Muñoz Moreno, Jose Antonio
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/355837
Acceso en línea:https://hdl.handle.net/2117/355837
https://dx.doi.org/10.1038/s41598-021-90678-6
Access Level:acceso abierto
Palabra clave:Classificació AMS::90 Operations research, mathematical programming
Àrees temàtiques de la UPC::Matemàtiques i estadística
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spelling Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infectionPrats París, AnnaMartínez Zalacaín, IgnacioMothe, Beatriz|||0000-0001-9975-407XNegredo Puigmal, EugèniaPérez Álvarez, Nuria|||0000-0001-6582-1553Garolera, MaiteDomènech Puigcerver, SiraColl, PepMeulbroek, M.Chamorro, AnnaRodriguez Fumaz, CarminaFerrer, MariaClotet Sala, BonaventuraSoriano Mas, CarlesMuñoz Moreno, Jose AntonioClassificació AMS::90 Operations research, mathematical programmingÀrees temàtiques de la UPC::Matemàtiques i estadísticaIntegrase strand transfer inhibitors (INSTI) are a main component of the current antiretroviral regimens recommended for treatment of HIV infection. However, little is known about the impact of INSTI on neurocognition and neuroimaging. We developed a prospective observational trial to evaluate the effects of INSTI-based antiretroviral therapy on comprehensive brain outcomes (cognitive, functional, and imaging) according to the time since HIV-1 acquisition. We recruited men living with HIV who initiated antiretroviral therapy with INSTI < 3 months since the estimated date of HIV-1 acquisition (n = 12) and > 6 months since estimated date of HIV-1 acquisition (n = 15). We also recruited a group of matched seronegative individuals (n = 15). Assessments were performed at baseline (before initiation of therapy in HIV arms) and at weeks 4 and 48. Baseline cognitive functioning was comparable between the arms. At week 48, we did not find cognitive differences between starting therapy with INSTI earlier than 3 months or later than 6 months after acquisition of HIV-1 infection. Functional status was poorer in individuals diagnosed earlier. This effect recovered 48 weeks after initiation of therapy. Regarding brain imaging, we found that men living with HIV initiating antiretroviral therapy later experienced a greater decrease in medial orbitofrontal cortex over time, with expected negative repercussions for decision-making tasks.The study was supported by Fundació Lluita Contra la SIDA (FLS-ANT 2015-01). IMZ was supported by a P-FIS grant (FI17/00294) and CSM by a Miguel Servet contract (CPII16/00048) from the Instituto de Salud Carlos III. NPA was partially supported by grants MTM2015-64465-C2-1-R (MINECO/FEDER) and 2017 SGR 622 (GRBIO)Peer ReviewedNature20212021-12-0120212021-11-09journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/355837https://dx.doi.org/10.1038/s41598-021-90678-6reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivs 3.0 Spainhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/3558372026-05-27T15:37:01Z
dc.title.none.fl_str_mv Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infection
title Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infection
spellingShingle Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infection
Prats París, Anna
Classificació AMS::90 Operations research, mathematical programming
Àrees temàtiques de la UPC::Matemàtiques i estadística
title_short Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infection
title_full Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infection
title_fullStr Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infection
title_full_unstemmed Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infection
title_sort Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infection
dc.creator.none.fl_str_mv Prats París, Anna
Martínez Zalacaín, Ignacio
Mothe, Beatriz|||0000-0001-9975-407X
Negredo Puigmal, Eugènia
Pérez Álvarez, Nuria|||0000-0001-6582-1553
Garolera, Maite
Domènech Puigcerver, Sira
Coll, Pep
Meulbroek, M.
Chamorro, Anna
Rodriguez Fumaz, Carmina
Ferrer, Maria
Clotet Sala, Bonaventura
Soriano Mas, Carles
Muñoz Moreno, Jose Antonio
author Prats París, Anna
author_facet Prats París, Anna
Martínez Zalacaín, Ignacio
Mothe, Beatriz|||0000-0001-9975-407X
Negredo Puigmal, Eugènia
Pérez Álvarez, Nuria|||0000-0001-6582-1553
Garolera, Maite
Domènech Puigcerver, Sira
Coll, Pep
Meulbroek, M.
Chamorro, Anna
Rodriguez Fumaz, Carmina
Ferrer, Maria
Clotet Sala, Bonaventura
Soriano Mas, Carles
Muñoz Moreno, Jose Antonio
author_role author
author2 Martínez Zalacaín, Ignacio
Mothe, Beatriz|||0000-0001-9975-407X
Negredo Puigmal, Eugènia
Pérez Álvarez, Nuria|||0000-0001-6582-1553
Garolera, Maite
Domènech Puigcerver, Sira
Coll, Pep
Meulbroek, M.
Chamorro, Anna
Rodriguez Fumaz, Carmina
Ferrer, Maria
Clotet Sala, Bonaventura
Soriano Mas, Carles
Muñoz Moreno, Jose Antonio
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Classificació AMS::90 Operations research, mathematical programming
Àrees temàtiques de la UPC::Matemàtiques i estadística
topic Classificació AMS::90 Operations research, mathematical programming
Àrees temàtiques de la UPC::Matemàtiques i estadística
description Integrase strand transfer inhibitors (INSTI) are a main component of the current antiretroviral regimens recommended for treatment of HIV infection. However, little is known about the impact of INSTI on neurocognition and neuroimaging. We developed a prospective observational trial to evaluate the effects of INSTI-based antiretroviral therapy on comprehensive brain outcomes (cognitive, functional, and imaging) according to the time since HIV-1 acquisition. We recruited men living with HIV who initiated antiretroviral therapy with INSTI < 3 months since the estimated date of HIV-1 acquisition (n = 12) and > 6 months since estimated date of HIV-1 acquisition (n = 15). We also recruited a group of matched seronegative individuals (n = 15). Assessments were performed at baseline (before initiation of therapy in HIV arms) and at weeks 4 and 48. Baseline cognitive functioning was comparable between the arms. At week 48, we did not find cognitive differences between starting therapy with INSTI earlier than 3 months or later than 6 months after acquisition of HIV-1 infection. Functional status was poorer in individuals diagnosed earlier. This effect recovered 48 weeks after initiation of therapy. Regarding brain imaging, we found that men living with HIV initiating antiretroviral therapy later experienced a greater decrease in medial orbitofrontal cortex over time, with expected negative repercussions for decision-making tasks.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-12-01
2021
2021-11-09
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/355837
https://dx.doi.org/10.1038/s41598-021-90678-6
url https://hdl.handle.net/2117/355837
https://dx.doi.org/10.1038/s41598-021-90678-6
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature
publisher.none.fl_str_mv Nature
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
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