Mediterranean diet maintained platelet count within a healthy range and decreased thrombocytopenia-related mortality risk: a randomized controlled trial

There is little information on the dietary modulation of thrombosis-related risk factors such as platelet count. We aimed to assess the effects of Mediterranean diet (MedDiet) on platelet count and related outcomes in an older population at high cardiovascular risk. In participants of the PREDIMED (...

ver descrição completa

Detalhes bibliográficos
Autores: Hernáez, Álvaro, Lassale, Camille, Castro-Barquero, Sara, Ros Rahola, Emilio, Tresserra-Rimbau, Anna, Castañer, Olga, Pintó Sala, Xavier, Vázquez Ruiz, Zenaida, Sorlí, José V., Salas Salvadó, Jordi, Lapetra, José, Gómez-Gracia, Enrique, Alonso Gómez, Ángel M., Fiol, Miquel, Serra Majem, Lluís, Sacanella Meseguer, Emilio, Razquin, Cristina, Corella Piquer, Dolores, Guasch-Ferré, Marta, Cofán Pujol, Montserrat, Estruch Riba, Ramon
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Recursos:Universitat Ramon Llull (URL)
Repositorio:DAU Arxiu Digital de la Universitat Ramon Llull
OAI Identifier:oai:dau.url.edu:20.500.14342/761
Acesso em linha:http://hdl.handle.net/20.500.14342/761
https://doi.org/10.3390/nu13020559
Access Level:acceso abierto
Palavra-chave:Dieta mediterrània
Plaquetes sanguínies --Trastorns
Trombocitopènia -- Prevenció
613
616.1
id ES_8b1c4cebd856477be9f5b5ed3f25c57f
oai_identifier_str oai:dau.url.edu:20.500.14342/761
network_acronym_str ES
network_name_str España
repository_id_str
spelling Mediterranean diet maintained platelet count within a healthy range and decreased thrombocytopenia-related mortality risk: a randomized controlled trialHernáez, ÁlvaroLassale, CamilleCastro-Barquero, SaraRos Rahola, EmilioTresserra-Rimbau, AnnaCastañer, OlgaPintó Sala, XavierVázquez Ruiz, ZenaidaSorlí, José V.Salas Salvadó, JordiLapetra, JoséGómez-Gracia, EnriqueAlonso Gómez, Ángel M.Fiol, MiquelSerra Majem, LluísSacanella Meseguer, EmilioRazquin, CristinaCorella Piquer, DoloresGuasch-Ferré, MartaCofán Pujol, MontserratEstruch Riba, RamonDieta mediterràniaPlaquetes sanguínies --TrastornsTrombocitopènia -- Prevenció613616.1There is little information on the dietary modulation of thrombosis-related risk factors such as platelet count. We aimed to assess the effects of Mediterranean diet (MedDiet) on platelet count and related outcomes in an older population at high cardiovascular risk. In participants of the PREDIMED (PREvención con DIeta MEDiterránea) study, we assessed whether an intervention with a MedDiet enriched with extra-virgin olive oil or nuts, relative to a low-fat control diet, modulated platelet count (n = 4189), the risk of developing thrombocytosis and thrombocytopenia (n = 3086), and the association between these alterations and all-cause mortality (median follow-up time: 3.0 years). Although platelet count increased over time (+0.98·109 units/L·year [95% confidence interval: 0.12; 1.84]), MedDiet interventions moderated this increase, particularly in individuals with near-high baseline count (both MedDiets combined: −3.20·109 units/L·year [−5.81; −0.59]). Thrombocytopenia incidence was lower in the MedDiet interventions (incidence rates: 2.23% in control diet, 0.91% in MedDiets combined; hazard ratio: 0.44 [0.23; 0.83]). Finally, thrombocytopenia was associated with a higher risk of all-cause mortality (hazard ratio: 4.71 [2.69; 8.24]), but this relationship was attenuated in those allocated to MedDiet (p-interaction = 0.018). In brief, MedDiet maintained platelet counts within a healthy range and attenuated platelet-related mortality in older adults at high cardiovascular risk.MDPIUniversitat Ramon Llull. Facultat de Ciències de la Salut Blanquerna202320232023202320212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion13 p.application/pdfhttp://hdl.handle.net/20.500.14342/761https://doi.org/10.3390/nu13020559RECERCAT (Dipòsit de la Recerca de Catalunya)reponame:DAU Arxiu Digital de la Universitat Ramon Llullinstname:Universitat Ramon Llull (URL)InglésNutrients, 2021, 13, 559info:eu-repo/grantAgreement/MINECO/ISCIII/CB06info:eu-repo/grantAgreement/MINECO/ISCIII/CB06info:eu-repo/grantAgreement/MINECO/ISCIII/CD17info:eu-repo/grantAgreement/MINECO/ISCIII/PIE14info:eu-repo/grantAgreement/MINECO/ISCIII/OBN17PI02info:eu-repo/grantAgreement/SUR del DEC/SGR/2017 SGR 222info:eu-repo/grantAgreement/MICINN/PN I+D/FPU17info:eu-repo/grantAgreement/SUR del DEC/BP/2017-BP-00021Attribution 4.0 International© L'autor/ahttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dau.url.edu:20.500.14342/7612026-06-21T06:40:37Z
dc.title.none.fl_str_mv Mediterranean diet maintained platelet count within a healthy range and decreased thrombocytopenia-related mortality risk: a randomized controlled trial
title Mediterranean diet maintained platelet count within a healthy range and decreased thrombocytopenia-related mortality risk: a randomized controlled trial
spellingShingle Mediterranean diet maintained platelet count within a healthy range and decreased thrombocytopenia-related mortality risk: a randomized controlled trial
Hernáez, Álvaro
Dieta mediterrània
Plaquetes sanguínies --Trastorns
Trombocitopènia -- Prevenció
613
616.1
title_short Mediterranean diet maintained platelet count within a healthy range and decreased thrombocytopenia-related mortality risk: a randomized controlled trial
title_full Mediterranean diet maintained platelet count within a healthy range and decreased thrombocytopenia-related mortality risk: a randomized controlled trial
title_fullStr Mediterranean diet maintained platelet count within a healthy range and decreased thrombocytopenia-related mortality risk: a randomized controlled trial
title_full_unstemmed Mediterranean diet maintained platelet count within a healthy range and decreased thrombocytopenia-related mortality risk: a randomized controlled trial
title_sort Mediterranean diet maintained platelet count within a healthy range and decreased thrombocytopenia-related mortality risk: a randomized controlled trial
dc.creator.none.fl_str_mv Hernáez, Álvaro
Lassale, Camille
Castro-Barquero, Sara
Ros Rahola, Emilio
Tresserra-Rimbau, Anna
Castañer, Olga
Pintó Sala, Xavier
Vázquez Ruiz, Zenaida
Sorlí, José V.
Salas Salvadó, Jordi
Lapetra, José
Gómez-Gracia, Enrique
Alonso Gómez, Ángel M.
Fiol, Miquel
Serra Majem, Lluís
Sacanella Meseguer, Emilio
Razquin, Cristina
Corella Piquer, Dolores
Guasch-Ferré, Marta
Cofán Pujol, Montserrat
Estruch Riba, Ramon
author Hernáez, Álvaro
author_facet Hernáez, Álvaro
Lassale, Camille
Castro-Barquero, Sara
Ros Rahola, Emilio
Tresserra-Rimbau, Anna
Castañer, Olga
Pintó Sala, Xavier
Vázquez Ruiz, Zenaida
Sorlí, José V.
Salas Salvadó, Jordi
Lapetra, José
Gómez-Gracia, Enrique
Alonso Gómez, Ángel M.
Fiol, Miquel
Serra Majem, Lluís
Sacanella Meseguer, Emilio
Razquin, Cristina
Corella Piquer, Dolores
Guasch-Ferré, Marta
Cofán Pujol, Montserrat
Estruch Riba, Ramon
author_role author
author2 Lassale, Camille
Castro-Barquero, Sara
Ros Rahola, Emilio
Tresserra-Rimbau, Anna
Castañer, Olga
Pintó Sala, Xavier
Vázquez Ruiz, Zenaida
Sorlí, José V.
Salas Salvadó, Jordi
Lapetra, José
Gómez-Gracia, Enrique
Alonso Gómez, Ángel M.
Fiol, Miquel
Serra Majem, Lluís
Sacanella Meseguer, Emilio
Razquin, Cristina
Corella Piquer, Dolores
Guasch-Ferré, Marta
Cofán Pujol, Montserrat
Estruch Riba, Ramon
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Ramon Llull. Facultat de Ciències de la Salut Blanquerna
dc.subject.none.fl_str_mv Dieta mediterrània
Plaquetes sanguínies --Trastorns
Trombocitopènia -- Prevenció
613
616.1
topic Dieta mediterrània
Plaquetes sanguínies --Trastorns
Trombocitopènia -- Prevenció
613
616.1
description There is little information on the dietary modulation of thrombosis-related risk factors such as platelet count. We aimed to assess the effects of Mediterranean diet (MedDiet) on platelet count and related outcomes in an older population at high cardiovascular risk. In participants of the PREDIMED (PREvención con DIeta MEDiterránea) study, we assessed whether an intervention with a MedDiet enriched with extra-virgin olive oil or nuts, relative to a low-fat control diet, modulated platelet count (n = 4189), the risk of developing thrombocytosis and thrombocytopenia (n = 3086), and the association between these alterations and all-cause mortality (median follow-up time: 3.0 years). Although platelet count increased over time (+0.98·109 units/L·year [95% confidence interval: 0.12; 1.84]), MedDiet interventions moderated this increase, particularly in individuals with near-high baseline count (both MedDiets combined: −3.20·109 units/L·year [−5.81; −0.59]). Thrombocytopenia incidence was lower in the MedDiet interventions (incidence rates: 2.23% in control diet, 0.91% in MedDiets combined; hazard ratio: 0.44 [0.23; 0.83]). Finally, thrombocytopenia was associated with a higher risk of all-cause mortality (hazard ratio: 4.71 [2.69; 8.24]), but this relationship was attenuated in those allocated to MedDiet (p-interaction = 0.018). In brief, MedDiet maintained platelet counts within a healthy range and attenuated platelet-related mortality in older adults at high cardiovascular risk.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2023
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.14342/761
https://doi.org/10.3390/nu13020559
url http://hdl.handle.net/20.500.14342/761
https://doi.org/10.3390/nu13020559
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Nutrients, 2021, 13, 559
info:eu-repo/grantAgreement/MINECO/ISCIII/CB06
info:eu-repo/grantAgreement/MINECO/ISCIII/CB06
info:eu-repo/grantAgreement/MINECO/ISCIII/CD17
info:eu-repo/grantAgreement/MINECO/ISCIII/PIE14
info:eu-repo/grantAgreement/MINECO/ISCIII/OBN17PI02
info:eu-repo/grantAgreement/SUR del DEC/SGR/2017 SGR 222
info:eu-repo/grantAgreement/MICINN/PN I+D/FPU17
info:eu-repo/grantAgreement/SUR del DEC/BP/2017-BP-00021
dc.rights.none.fl_str_mv Attribution 4.0 International
© L'autor/a
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
© L'autor/a
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 13 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv RECERCAT (Dipòsit de la Recerca de Catalunya)
reponame:DAU Arxiu Digital de la Universitat Ramon Llull
instname:Universitat Ramon Llull (URL)
instname_str Universitat Ramon Llull (URL)
reponame_str DAU Arxiu Digital de la Universitat Ramon Llull
collection DAU Arxiu Digital de la Universitat Ramon Llull
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869412783673573376
score 15,300724

Registos relacionados