Mesoporous Silica Nanoparticles for the Potential Treatment of Osteoporosis

The overall objective of this PhD thesis has been the design of mesoporous nanoparticles for biomedical applications. In particular, this doctoral thesis has comprised the development of a nanocarrier for the potential treatment of bone diseases, more specifically in osteoporosis. The initial contex...

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Detalles Bibliográficos
Autor: Mora Raimundo, Patricia
Tipo de recurso: tesis doctoral
Fecha de publicación:2021
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/11699
Acceso en línea:https://hdl.handle.net/20.500.14352/11699
Access Level:acceso abierto
Palabra clave:616.71-007.234(043.2)
Osteoporosis
Sistema musculoesquelético
2411.10 Fisiología del Músculo
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spelling Mesoporous Silica Nanoparticles for the Potential Treatment of OsteoporosisNanopartículas Mesoporosas de Sílice para el Tratamiento Potencial de la OsteoporosisMora Raimundo, Patricia616.71-007.234(043.2)OsteoporosisSistema musculoesquelético2411.10 Fisiología del MúsculoThe overall objective of this PhD thesis has been the design of mesoporous nanoparticles for biomedical applications. In particular, this doctoral thesis has comprised the development of a nanocarrier for the potential treatment of bone diseases, more specifically in osteoporosis. The initial context of this doctoral thesis was the European project “VERDI” (“polyValent mEsopoRous naosystem for bone DIseases”). The proposal involved the use of mesoporous materials to treat three situations of clinical relevance in bone pathology: bone infection, bone cancer (primary tumors and bone metastases) and osteoporosis. Osteoporosis is considered the most prevalent disease involving bone degeneration. It is a silent disease and due to the aging population is considered one of the major public health problems facing postmenopausal women and aging individuals of both sexes. Although several effective antiosteoporotic treatments have been developed, their side effects limit their further application. Therefore, many efforts have been headed towards the development of other alternatives for osteoporosis treatment reducing their drawbacks for a better long-term use and adherence...Universidad Complutense de MadridManzano García, MiguelHawkins Carranza, Federico GilbertoUniversidad Complutense de Madrid20212021-06-0920212021-06-09doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttps://hdl.handle.net/20.500.14352/11699reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/116992026-06-02T12:44:21Z
dc.title.none.fl_str_mv Mesoporous Silica Nanoparticles for the Potential Treatment of Osteoporosis
Nanopartículas Mesoporosas de Sílice para el Tratamiento Potencial de la Osteoporosis
title Mesoporous Silica Nanoparticles for the Potential Treatment of Osteoporosis
spellingShingle Mesoporous Silica Nanoparticles for the Potential Treatment of Osteoporosis
Mora Raimundo, Patricia
616.71-007.234(043.2)
Osteoporosis
Sistema musculoesquelético
2411.10 Fisiología del Músculo
title_short Mesoporous Silica Nanoparticles for the Potential Treatment of Osteoporosis
title_full Mesoporous Silica Nanoparticles for the Potential Treatment of Osteoporosis
title_fullStr Mesoporous Silica Nanoparticles for the Potential Treatment of Osteoporosis
title_full_unstemmed Mesoporous Silica Nanoparticles for the Potential Treatment of Osteoporosis
title_sort Mesoporous Silica Nanoparticles for the Potential Treatment of Osteoporosis
dc.creator.none.fl_str_mv Mora Raimundo, Patricia
author Mora Raimundo, Patricia
author_facet Mora Raimundo, Patricia
author_role author
dc.contributor.none.fl_str_mv Manzano García, Miguel
Hawkins Carranza, Federico Gilberto
Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 616.71-007.234(043.2)
Osteoporosis
Sistema musculoesquelético
2411.10 Fisiología del Músculo
topic 616.71-007.234(043.2)
Osteoporosis
Sistema musculoesquelético
2411.10 Fisiología del Músculo
description The overall objective of this PhD thesis has been the design of mesoporous nanoparticles for biomedical applications. In particular, this doctoral thesis has comprised the development of a nanocarrier for the potential treatment of bone diseases, more specifically in osteoporosis. The initial context of this doctoral thesis was the European project “VERDI” (“polyValent mEsopoRous naosystem for bone DIseases”). The proposal involved the use of mesoporous materials to treat three situations of clinical relevance in bone pathology: bone infection, bone cancer (primary tumors and bone metastases) and osteoporosis. Osteoporosis is considered the most prevalent disease involving bone degeneration. It is a silent disease and due to the aging population is considered one of the major public health problems facing postmenopausal women and aging individuals of both sexes. Although several effective antiosteoporotic treatments have been developed, their side effects limit their further application. Therefore, many efforts have been headed towards the development of other alternatives for osteoporosis treatment reducing their drawbacks for a better long-term use and adherence...
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-06-09
2021
2021-06-09
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/11699
url https://hdl.handle.net/20.500.14352/11699
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad Complutense de Madrid
publisher.none.fl_str_mv Universidad Complutense de Madrid
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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