The brazilian Amaryllidaceae as a source of acetylcholinesterase inhibitory alkaloids

Nine Brazilian Amaryllidaceae species were studied for their alkaloid composition and acetylcholinesterase (AChE) inhibitory activity via GC-MS and a modified Ellman assay, respectively. A total of thirty-six alkaloids were identified in these plants, of which Hippeastrum papilio and H. glau-cescens...

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Bibliographic Details
Authors: Paulo de Andrade, Jean, Giordani, R. B., Torras Claveria, Laura, Pigni, Natalia Belén, Berkov, Strahil, Font Bardia, Ma. Mercedes, Calvet Pallàs, Maria Teresa, Konrath, E., Bueno, K., Sachett, L. G., Dutilh, J. H., Borges, W. D., Viladomat Meya, Francesc, Henriques, A. T., Nair, Jerald J., Zuanazzi, José Ângelo Silveira, Bastida Armengol, Jaume
Format: article
Status:Versión aceptada para publicación
Publication Date:2016
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/163721
Online Access:https://hdl.handle.net/2445/163721
Access Level:Open access
Keyword:Alcaloides
Radiocristal·lografia
Alkaloids
X-ray crystallography
Description
Summary:Nine Brazilian Amaryllidaceae species were studied for their alkaloid composition and acetylcholinesterase (AChE) inhibitory activity via GC-MS and a modified Ellman assay, respectively. A total of thirty-six alkaloids were identified in these plants, of which Hippeastrum papilio and H. glau-cescens exhibited the highest galanthamine content and the best IC50 values against AChE. Furthermore, Hippeastrum vittatum and Rhodophiala bifida also showed notable AChE inhibitory effects. X-ray crys-tallographic data for four galanthamine-type com-pounds revealed significant differences in the orientation of theN-methyl group, which are shown to be related to AChE inhibition.

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