The brazilian Amaryllidaceae as a source of acetylcholinesterase inhibitory alkaloids

Nine Brazilian Amaryllidaceae species were studied for their alkaloid composition and acetylcholinesterase (AChE) inhibitory activity via GC-MS and a modified Ellman assay, respectively. A total of thirty-six alkaloids were identified in these plants, of which Hippeastrum papilio and H. glau-cescens...

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Detalles Bibliográficos
Autores: Paulo de Andrade, Jean, Giordani, R. B., Torras Claveria, Laura, Pigni, Natalia Belén, Berkov, Strahil, Font Bardia, Ma. Mercedes, Calvet Pallàs, Maria Teresa, Konrath, E., Bueno, K., Sachett, L. G., Dutilh, J. H., Borges, W. D., Viladomat Meya, Francesc, Henriques, A. T., Nair, Jerald J., Zuanazzi, José Ângelo Silveira, Bastida Armengol, Jaume
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2016
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/163721
Acceso en línea:https://hdl.handle.net/2445/163721
Access Level:acceso abierto
Palabra clave:Alcaloides
Radiocristal·lografia
Alkaloids
X-ray crystallography
Descripción
Sumario:Nine Brazilian Amaryllidaceae species were studied for their alkaloid composition and acetylcholinesterase (AChE) inhibitory activity via GC-MS and a modified Ellman assay, respectively. A total of thirty-six alkaloids were identified in these plants, of which Hippeastrum papilio and H. glau-cescens exhibited the highest galanthamine content and the best IC50 values against AChE. Furthermore, Hippeastrum vittatum and Rhodophiala bifida also showed notable AChE inhibitory effects. X-ray crys-tallographic data for four galanthamine-type com-pounds revealed significant differences in the orientation of theN-methyl group, which are shown to be related to AChE inhibition.

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