Influence of the surface topography of titanium dental implants on the behavior of human amniotic stem cells

The work was supported by the Spanish Government and the Ministry of Science and Innovation of Spain through research projects CONCEPTO PDC2022-133628-C22 (co-funded by the European Regional Development Fund (ERDF), a way to build Europe) and research project MINECO (PID2022-137496OB-I00).

Detalhes bibliográficos
Autores: Riedel, Rodrigo, Perez-Amodio, Soledad, Cabo Zabala, Laura, Velasco-Ortega, Eugenio, Maymó, Julieta, Gil, FJ, Monsalve-Guil, Loreto, Ortiz-Garcia, Iván, Pérez Pérez, Antonio, Sánchez-Margalet, Victor, Jiménez Guerra, Alvaro
Tipo de documento: artigo
Data de publicação:2024
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.12328/4808
Acesso em linha:http://hdl.handle.net/20.500.12328/4808
https://dx.doi.org/10.3390/ijms25137416
Access Level:Acceso aberto
Palavra-chave:Titani
Superfícies
Cèl·lules mare amniòtiques
Implants dentals
Titanio
Superficies
Células madre amnióticas
Implantes dentales
Titanium
Surfaces
Amniotic stem cells
Dental implants
616.3
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oai_identifier_str oai:recercat.cat:20.500.12328/4808
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repository_id_str
spelling Influence of the surface topography of titanium dental implants on the behavior of human amniotic stem cellsRiedel, RodrigoPerez-Amodio, SoledadCabo Zabala, LauraVelasco-Ortega, EugenioMaymó, JulietaGil, FJMonsalve-Guil, LoretoOrtiz-Garcia, IvánPérez Pérez, AntonioSánchez-Margalet, VictorJiménez Guerra, AlvaroTitaniSuperfíciesCèl·lules mare amniòtiquesImplants dentalsTitanioSuperficiesCélulas madre amnióticasImplantes dentalesTitaniumSurfacesAmniotic stem cellsDental implants616.3The work was supported by the Spanish Government and the Ministry of Science and Innovation of Spain through research projects CONCEPTO PDC2022-133628-C22 (co-funded by the European Regional Development Fund (ERDF), a way to build Europe) and research project MINECO (PID2022-137496OB-I00).The dental implant surface plays a crucial role in osseointegration. The topography and physicochemical properties will affect the cellular functions. In this research, four distinct titanium surfaces have been studied: machined acting (MACH), acid etched (AE), grit blasting (GBLAST), and a combination of grit blasting and subsequent acid etching (GBLAST + AE). Human amniotic mesenchymal (hAMSCs) and epithelial stem cells (hAECs) isolated from the amniotic membrane have attractive stem-cell properties. They were cultured on titanium surfaces to analyze their impact on biological behavior. The surface roughness, microhardness, wettability, and surface energy were analyzed using interferometric microscopy, Vickers indentation, and drop-sessile techniques. The GBLAST and GBLAST + AE surfaces showed higher roughness, reduced hydrophilicity, and lower surface energy with significant differences. Increased microhardness values for GBLAST and GBLAST + AE implants were attributed to surface compression. Cell viability was higher for hAMSCs, particularly on GBLAST and GBLAST + AE surfaces. Alkaline phosphatase activity enhanced in hAMSCs cultured on GBLAST and GBLAST + AE surfaces, while hAECs showed no mineralization signals. Osteogenic gene expression was upregulated in hAMSCs on GBLAST surfaces. Moreover, α2 and β1 integrin expression enhanced in hAMSCs, suggesting a surface−integrin interaction. Consequently, hAMSCs would tend toward osteoblastic differentiation on grit-blasted surfaces conducive to osseointegration, a phenomenon not observed in hAECs.info:eu-repo/semantics/publishedVersionMDPI2024info:eu-repo/semantics/article17http://hdl.handle.net/20.500.12328/4808https://dx.doi.org/10.3390/ijms25137416reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésInternational Journal of Molecular Sciences25;13© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.12328/48082026-05-29T05:05:01Z
dc.title.none.fl_str_mv Influence of the surface topography of titanium dental implants on the behavior of human amniotic stem cells
title Influence of the surface topography of titanium dental implants on the behavior of human amniotic stem cells
spellingShingle Influence of the surface topography of titanium dental implants on the behavior of human amniotic stem cells
Riedel, Rodrigo
Titani
Superfícies
Cèl·lules mare amniòtiques
Implants dentals
Titanio
Superficies
Células madre amnióticas
Implantes dentales
Titanium
Surfaces
Amniotic stem cells
Dental implants
616.3
title_short Influence of the surface topography of titanium dental implants on the behavior of human amniotic stem cells
title_full Influence of the surface topography of titanium dental implants on the behavior of human amniotic stem cells
title_fullStr Influence of the surface topography of titanium dental implants on the behavior of human amniotic stem cells
title_full_unstemmed Influence of the surface topography of titanium dental implants on the behavior of human amniotic stem cells
title_sort Influence of the surface topography of titanium dental implants on the behavior of human amniotic stem cells
dc.creator.none.fl_str_mv Riedel, Rodrigo
Perez-Amodio, Soledad
Cabo Zabala, Laura
Velasco-Ortega, Eugenio
Maymó, Julieta
Gil, FJ
Monsalve-Guil, Loreto
Ortiz-Garcia, Iván
Pérez Pérez, Antonio
Sánchez-Margalet, Victor
Jiménez Guerra, Alvaro
author Riedel, Rodrigo
author_facet Riedel, Rodrigo
Perez-Amodio, Soledad
Cabo Zabala, Laura
Velasco-Ortega, Eugenio
Maymó, Julieta
Gil, FJ
Monsalve-Guil, Loreto
Ortiz-Garcia, Iván
Pérez Pérez, Antonio
Sánchez-Margalet, Victor
Jiménez Guerra, Alvaro
author_role author
author2 Perez-Amodio, Soledad
Cabo Zabala, Laura
Velasco-Ortega, Eugenio
Maymó, Julieta
Gil, FJ
Monsalve-Guil, Loreto
Ortiz-Garcia, Iván
Pérez Pérez, Antonio
Sánchez-Margalet, Victor
Jiménez Guerra, Alvaro
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Titani
Superfícies
Cèl·lules mare amniòtiques
Implants dentals
Titanio
Superficies
Células madre amnióticas
Implantes dentales
Titanium
Surfaces
Amniotic stem cells
Dental implants
616.3
topic Titani
Superfícies
Cèl·lules mare amniòtiques
Implants dentals
Titanio
Superficies
Células madre amnióticas
Implantes dentales
Titanium
Surfaces
Amniotic stem cells
Dental implants
616.3
description The work was supported by the Spanish Government and the Ministry of Science and Innovation of Spain through research projects CONCEPTO PDC2022-133628-C22 (co-funded by the European Regional Development Fund (ERDF), a way to build Europe) and research project MINECO (PID2022-137496OB-I00).
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12328/4808
https://dx.doi.org/10.3390/ijms25137416
url http://hdl.handle.net/20.500.12328/4808
https://dx.doi.org/10.3390/ijms25137416
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv International Journal of Molecular Sciences
25;13
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 17
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869412636240642048
score 15,812429

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