Associations of Maternal Educational Level, Proximity to Green Space During Pregnancy, and Gestational Diabetes With Body Mass Index From Infancy to Early Adulthood: A Proof-of-Concept Federated Analysis in 18 Birth Cohorts
International sharing of cohort data for research is important and challenging. We explored the feasibility of multicohort federated analyses by examining associations between 3 pregnancy exposures (maternal education, exposure to green vegetation, and gestational diabetes) and offspring body mass i...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
| Repositorio: | r-FISABIO. Repositorio Institucional de Producción Científica |
| OAI Identifier: | oai:fisabio.fundanetsuite.com:p18065 |
| Acceso en línea: | https://fisabio.portalinvestigacion.com/publicaciones/18065 |
| Access Level: | acceso abierto |
| Palabra clave: | BMI cohort data sharing federated analyses gestational diabetes green spaces maternal education |
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Associations of Maternal Educational Level, Proximity to Green Space During Pregnancy, and Gestational Diabetes With Body Mass Index From Infancy to Early Adulthood: A Proof-of-Concept Federated Analysis in 18 Birth CohortsCadman, TElhakeem, AVinther, JLAvraam, DCarrasco, PCalas, LCardol, MCharles, MACorpeleijn, ECrozier, Sde Castro, MEstarlich, MFernandes, AFossatti, SGruszfeld, DGuerlich, KGrote, VHaakma, SHarris, JRHeude, BHuang, RCIbarluzea, JInskip, HJaddoe, VKoletzko, BLioret, SLuque, VManios, YMoirano, GMoschonis, GNader, JNieuwenhuijsen, MAndersen, AMNMceachen, Rde Moira, APPopovic, MRoumeliotaki, TSalika, TSanta Marina, LSantos, SSerbert, STzorovili, EVafeiadi, MVerduci, EVrijheid, MVrijkotte, TGMWelten, MWright, JYang, TCZugna, DLawlor, DBMIcohort data sharingfederated analysesgestational diabetesgreen spacesmaternal educationInternational sharing of cohort data for research is important and challenging. We explored the feasibility of multicohort federated analyses by examining associations between 3 pregnancy exposures (maternal education, exposure to green vegetation, and gestational diabetes) and offspring body mass index (BMI) from infancy to age 17 years. We used data from 18 cohorts (n = 206,180 mother-child pairs) from the EU Child Cohort Network and derived BMI at ages 0-1, 2-3, 4-7, 8-13, and 14-17 years. Associations were estimated using linear regression via 1-stage individual participant data meta-analysis using DataSHIELD. Associations between lower maternal education and higher child BMI emerged from age 4 and increased with age (difference in BMI z score comparing low with high education, at age 2-3 years = 0.03 (95% confidence interval (CI): 0.00, 0.05), at 4-7 years = 0.16 (95% CI: 0.14, 0.17), and at 8-13 years = 0.24 (95% CI: 0.22, 0.26)). Gestational diabetes was positively associated with BMI from age 8 years (BMI z score difference = 0.18, 95% CI: 0.12, 0.25) but not at younger ages; however, associations attenuated towards the null when restricted to cohorts that measured gestational diabetes via universal screening. Exposure to green vegetation was weakly associated with higher BMI up to age 1 year but not at older ages. Opportunities of cross-cohort federated analyses are discussed.OXFORD UNIV PRESS INC2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/18065AMERICAN JOURNAL OF EPIDEMIOLOGYISSN: 00029262ISSNe: 14766256reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p180652026-06-11T12:45:17Z |
| dc.title.none.fl_str_mv |
Associations of Maternal Educational Level, Proximity to Green Space During Pregnancy, and Gestational Diabetes With Body Mass Index From Infancy to Early Adulthood: A Proof-of-Concept Federated Analysis in 18 Birth Cohorts |
| title |
Associations of Maternal Educational Level, Proximity to Green Space During Pregnancy, and Gestational Diabetes With Body Mass Index From Infancy to Early Adulthood: A Proof-of-Concept Federated Analysis in 18 Birth Cohorts |
| spellingShingle |
Associations of Maternal Educational Level, Proximity to Green Space During Pregnancy, and Gestational Diabetes With Body Mass Index From Infancy to Early Adulthood: A Proof-of-Concept Federated Analysis in 18 Birth Cohorts Cadman, T BMI cohort data sharing federated analyses gestational diabetes green spaces maternal education |
| title_short |
Associations of Maternal Educational Level, Proximity to Green Space During Pregnancy, and Gestational Diabetes With Body Mass Index From Infancy to Early Adulthood: A Proof-of-Concept Federated Analysis in 18 Birth Cohorts |
| title_full |
Associations of Maternal Educational Level, Proximity to Green Space During Pregnancy, and Gestational Diabetes With Body Mass Index From Infancy to Early Adulthood: A Proof-of-Concept Federated Analysis in 18 Birth Cohorts |
| title_fullStr |
Associations of Maternal Educational Level, Proximity to Green Space During Pregnancy, and Gestational Diabetes With Body Mass Index From Infancy to Early Adulthood: A Proof-of-Concept Federated Analysis in 18 Birth Cohorts |
| title_full_unstemmed |
Associations of Maternal Educational Level, Proximity to Green Space During Pregnancy, and Gestational Diabetes With Body Mass Index From Infancy to Early Adulthood: A Proof-of-Concept Federated Analysis in 18 Birth Cohorts |
| title_sort |
Associations of Maternal Educational Level, Proximity to Green Space During Pregnancy, and Gestational Diabetes With Body Mass Index From Infancy to Early Adulthood: A Proof-of-Concept Federated Analysis in 18 Birth Cohorts |
| dc.creator.none.fl_str_mv |
Cadman, T Elhakeem, A Vinther, JL Avraam, D Carrasco, P Calas, L Cardol, M Charles, MA Corpeleijn, E Crozier, S de Castro, M Estarlich, M Fernandes, A Fossatti, S Gruszfeld, D Guerlich, K Grote, V Haakma, S Harris, JR Heude, B Huang, RC Ibarluzea, J Inskip, H Jaddoe, V Koletzko, B Lioret, S Luque, V Manios, Y Moirano, G Moschonis, G Nader, J Nieuwenhuijsen, M Andersen, AMN Mceachen, R de Moira, AP Popovic, M Roumeliotaki, T Salika, T Santa Marina, L Santos, S Serbert, S Tzorovili, E Vafeiadi, M Verduci, E Vrijheid, M Vrijkotte, TGM Welten, M Wright, J Yang, TC Zugna, D Lawlor, D |
| author |
Cadman, T |
| author_facet |
Cadman, T Elhakeem, A Vinther, JL Avraam, D Carrasco, P Calas, L Cardol, M Charles, MA Corpeleijn, E Crozier, S de Castro, M Estarlich, M Fernandes, A Fossatti, S Gruszfeld, D Guerlich, K Grote, V Haakma, S Harris, JR Heude, B Huang, RC Ibarluzea, J Inskip, H Jaddoe, V Koletzko, B Lioret, S Luque, V Manios, Y Moirano, G Moschonis, G Nader, J Nieuwenhuijsen, M Andersen, AMN Mceachen, R de Moira, AP Popovic, M Roumeliotaki, T Salika, T Santa Marina, L Santos, S Serbert, S Tzorovili, E Vafeiadi, M Verduci, E Vrijheid, M Vrijkotte, TGM Welten, M Wright, J Yang, TC Zugna, D Lawlor, D |
| author_role |
author |
| author2 |
Elhakeem, A Vinther, JL Avraam, D Carrasco, P Calas, L Cardol, M Charles, MA Corpeleijn, E Crozier, S de Castro, M Estarlich, M Fernandes, A Fossatti, S Gruszfeld, D Guerlich, K Grote, V Haakma, S Harris, JR Heude, B Huang, RC Ibarluzea, J Inskip, H Jaddoe, V Koletzko, B Lioret, S Luque, V Manios, Y Moirano, G Moschonis, G Nader, J Nieuwenhuijsen, M Andersen, AMN Mceachen, R de Moira, AP Popovic, M Roumeliotaki, T Salika, T Santa Marina, L Santos, S Serbert, S Tzorovili, E Vafeiadi, M Verduci, E Vrijheid, M Vrijkotte, TGM Welten, M Wright, J Yang, TC Zugna, D Lawlor, D |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
BMI cohort data sharing federated analyses gestational diabetes green spaces maternal education |
| topic |
BMI cohort data sharing federated analyses gestational diabetes green spaces maternal education |
| description |
International sharing of cohort data for research is important and challenging. We explored the feasibility of multicohort federated analyses by examining associations between 3 pregnancy exposures (maternal education, exposure to green vegetation, and gestational diabetes) and offspring body mass index (BMI) from infancy to age 17 years. We used data from 18 cohorts (n = 206,180 mother-child pairs) from the EU Child Cohort Network and derived BMI at ages 0-1, 2-3, 4-7, 8-13, and 14-17 years. Associations were estimated using linear regression via 1-stage individual participant data meta-analysis using DataSHIELD. Associations between lower maternal education and higher child BMI emerged from age 4 and increased with age (difference in BMI z score comparing low with high education, at age 2-3 years = 0.03 (95% confidence interval (CI): 0.00, 0.05), at 4-7 years = 0.16 (95% CI: 0.14, 0.17), and at 8-13 years = 0.24 (95% CI: 0.22, 0.26)). Gestational diabetes was positively associated with BMI from age 8 years (BMI z score difference = 0.18, 95% CI: 0.12, 0.25) but not at younger ages; however, associations attenuated towards the null when restricted to cohorts that measured gestational diabetes via universal screening. Exposure to green vegetation was weakly associated with higher BMI up to age 1 year but not at older ages. Opportunities of cross-cohort federated analyses are discussed. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://fisabio.portalinvestigacion.com/publicaciones/18065 |
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https://fisabio.portalinvestigacion.com/publicaciones/18065 |
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Inglés |
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Inglés |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
OXFORD UNIV PRESS INC |
| publisher.none.fl_str_mv |
OXFORD UNIV PRESS INC |
| dc.source.none.fl_str_mv |
AMERICAN JOURNAL OF EPIDEMIOLOGY ISSN: 00029262 ISSNe: 14766256 reponame:r-FISABIO. Repositorio Institucional de Producción Científica instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
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Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
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r-FISABIO. Repositorio Institucional de Producción Científica |
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r-FISABIO. Repositorio Institucional de Producción Científica |
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1869412626093572096 |
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15,812429 |