Associations of Maternal Educational Level, Proximity to Green Space During Pregnancy, and Gestational Diabetes With Body Mass Index From Infancy to Early Adulthood: A Proof-of-Concept Federated Analysis in 18 Birth Cohorts

International sharing of cohort data for research is important and challenging. We explored the feasibility of multicohort federated analyses by examining associations between 3 pregnancy exposures (maternal education, exposure to green vegetation, and gestational diabetes) and offspring body mass i...

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Detalles Bibliográficos
Autores: Cadman, T, Elhakeem, A, Vinther, JL, Avraam, D, Carrasco, P, Calas, L, Cardol, M, Charles, MA, Corpeleijn, E, Crozier, S, de Castro, M, Estarlich, M, Fernandes, A, Fossatti, S, Gruszfeld, D, Guerlich, K, Grote, V, Haakma, S, Harris, JR, Heude, B, Huang, RC, Ibarluzea, J, Inskip, H, Jaddoe, V, Koletzko, B, Lioret, S, Luque, V, Manios, Y, Moirano, G, Moschonis, G, Nader, J, Nieuwenhuijsen, M, Andersen, AMN, Mceachen, R, de Moira, AP, Popovic, M, Roumeliotaki, T, Salika, T, Santa Marina, L, Santos, S, Serbert, S, Tzorovili, E, Vafeiadi, M, Verduci, E, Vrijheid, M, Vrijkotte, TGM, Welten, M, Wright, J, Yang, TC, Zugna, D, Lawlor, D
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p18065
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/18065
Access Level:acceso abierto
Palabra clave:BMI
cohort data sharing
federated analyses
gestational diabetes
green spaces
maternal education
Descripción
Sumario:International sharing of cohort data for research is important and challenging. We explored the feasibility of multicohort federated analyses by examining associations between 3 pregnancy exposures (maternal education, exposure to green vegetation, and gestational diabetes) and offspring body mass index (BMI) from infancy to age 17 years. We used data from 18 cohorts (n = 206,180 mother-child pairs) from the EU Child Cohort Network and derived BMI at ages 0-1, 2-3, 4-7, 8-13, and 14-17 years. Associations were estimated using linear regression via 1-stage individual participant data meta-analysis using DataSHIELD. Associations between lower maternal education and higher child BMI emerged from age 4 and increased with age (difference in BMI z score comparing low with high education, at age 2-3 years = 0.03 (95% confidence interval (CI): 0.00, 0.05), at 4-7 years = 0.16 (95% CI: 0.14, 0.17), and at 8-13 years = 0.24 (95% CI: 0.22, 0.26)). Gestational diabetes was positively associated with BMI from age 8 years (BMI z score difference = 0.18, 95% CI: 0.12, 0.25) but not at younger ages; however, associations attenuated towards the null when restricted to cohorts that measured gestational diabetes via universal screening. Exposure to green vegetation was weakly associated with higher BMI up to age 1 year but not at older ages. Opportunities of cross-cohort federated analyses are discussed.

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