Aberrant inflammatory responses to type I interferon in STAT2 or IRF9 deficiency

[Background]: Inflammatory phenomena such as hyperinflammation or hemophagocytic lymphohistiocytosis are a frequent yet paradoxical accompaniment to virus susceptibility in patients with impairment of type I interferon (IFN-I) signaling caused by deficiency of signal transducer and activator of tran...

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Detalles Bibliográficos
Autores: Gothe, Florian, Stremenova Spegarova, Jarmila, Hatton, Catherine F., Griffin, Helen, Sargent, Thomas, Cowley, Sally A., James, William, Roppelt, Anna, Shcherbina, Anna, Hauck, Fabian, Reyburn, H. T., Duncan, Christopher J.A., Hambleton , Sophie
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/350519
Acceso en línea:http://hdl.handle.net/10261/350519
Access Level:acceso abierto
Palabra clave:Type I interferon
Antiviral immunity
ISGF3
HLH
Type II interferon
GAF
STAT2
IRF9
Descripción
Sumario:[Background]: Inflammatory phenomena such as hyperinflammation or hemophagocytic lymphohistiocytosis are a frequent yet paradoxical accompaniment to virus susceptibility in patients with impairment of type I interferon (IFN-I) signaling caused by deficiency of signal transducer and activator of transcription 2 (STAT2) or IFN regulatory factor 9

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