Association of Staphylococcus aureus bacteriophages and curcumin in alginate hydrogel: towards an advanced multifunctional co-delivery topical skin platform

[EN] Skin disorders are often associated with oxidative stress and bacterial infections, emphasizing the need for dual therapeutic strategies. This study explores the feasibility of co-delivering the natural bioactive compound curcumin loaded in nanostructured lipid carriers (CUR-NLCs) and Staphyloc...

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Autores: Armal, Carole, Calderón-Jacinto, Rosa, Traore, Kandas, Devaud, Edouard, Seyer, Damien, Pauthe, Emmanuel, Mihajlovski, Agnès, Rodriguez Ruiz, Violeta, Soto-Prado, Alexandra, Rodriguez-Hernandez, Jose-Carlos|||0000-0002-1735-824X, Vallés Lluch, Ana|||0000-0002-7896-8666, Vilariño-Feltrer, Guillermo|||0000-0002-3063-3808
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/231565
Acceso en línea:https://riunet.upv.es/handle/10251/231565
Access Level:acceso abierto
Palabra clave:Bacteriophages
Alginate hydrogel
Curcumin
Skin diseases
Drug delivery systems
02.- Poner fin al hambre, conseguir la seguridad alimentaria y una mejor nutrición, y promover la agricultura sostenible
03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades
09.- Desarrollar infraestructuras resilientes, promover la industrialización inclusiva y sostenible, y fomentar la innovación
12.- Garantizar las pautas de consumo y de producción sostenibles
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oai_identifier_str oai:riunet.upv.es:10251/231565
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Association of Staphylococcus aureus bacteriophages and curcumin in alginate hydrogel: towards an advanced multifunctional co-delivery topical skin platform
title Association of Staphylococcus aureus bacteriophages and curcumin in alginate hydrogel: towards an advanced multifunctional co-delivery topical skin platform
spellingShingle Association of Staphylococcus aureus bacteriophages and curcumin in alginate hydrogel: towards an advanced multifunctional co-delivery topical skin platform
Armal, Carole
Bacteriophages
Alginate hydrogel
Curcumin
Skin diseases
Drug delivery systems
02.- Poner fin al hambre, conseguir la seguridad alimentaria y una mejor nutrición, y promover la agricultura sostenible
03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades
09.- Desarrollar infraestructuras resilientes, promover la industrialización inclusiva y sostenible, y fomentar la innovación
12.- Garantizar las pautas de consumo y de producción sostenibles
title_short Association of Staphylococcus aureus bacteriophages and curcumin in alginate hydrogel: towards an advanced multifunctional co-delivery topical skin platform
title_full Association of Staphylococcus aureus bacteriophages and curcumin in alginate hydrogel: towards an advanced multifunctional co-delivery topical skin platform
title_fullStr Association of Staphylococcus aureus bacteriophages and curcumin in alginate hydrogel: towards an advanced multifunctional co-delivery topical skin platform
title_full_unstemmed Association of Staphylococcus aureus bacteriophages and curcumin in alginate hydrogel: towards an advanced multifunctional co-delivery topical skin platform
title_sort Association of Staphylococcus aureus bacteriophages and curcumin in alginate hydrogel: towards an advanced multifunctional co-delivery topical skin platform
dc.creator.none.fl_str_mv Armal, Carole
Calderón-Jacinto, Rosa
Traore, Kandas
Devaud, Edouard
Seyer, Damien
Pauthe, Emmanuel
Mihajlovski, Agnès
Rodriguez Ruiz, Violeta
Soto-Prado, Alexandra
Rodriguez-Hernandez, Jose-Carlos|||0000-0002-1735-824X
Vallés Lluch, Ana|||0000-0002-7896-8666
Vilariño-Feltrer, Guillermo|||0000-0002-3063-3808
author Armal, Carole
author_facet Armal, Carole
Calderón-Jacinto, Rosa
Traore, Kandas
Devaud, Edouard
Seyer, Damien
Pauthe, Emmanuel
Mihajlovski, Agnès
Rodriguez Ruiz, Violeta
Soto-Prado, Alexandra
Rodriguez-Hernandez, Jose-Carlos|||0000-0002-1735-824X
Vallés Lluch, Ana|||0000-0002-7896-8666
Vilariño-Feltrer, Guillermo|||0000-0002-3063-3808
author_role author
author2 Calderón-Jacinto, Rosa
Traore, Kandas
Devaud, Edouard
Seyer, Damien
Pauthe, Emmanuel
Mihajlovski, Agnès
Rodriguez Ruiz, Violeta
Soto-Prado, Alexandra
Rodriguez-Hernandez, Jose-Carlos|||0000-0002-1735-824X
Vallés Lluch, Ana|||0000-0002-7896-8666
Vilariño-Feltrer, Guillermo|||0000-0002-3063-3808
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Termodinámica Aplicada
Centro de Biomateriales e Ingeniería Tisular
Escuela Técnica Superior de Ingeniería Industrial
AGENCIA ESTATAL DE INVESTIGACION
Agence Nationale de la Recherche, Francia
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv Bacteriophages
Alginate hydrogel
Curcumin
Skin diseases
Drug delivery systems
02.- Poner fin al hambre, conseguir la seguridad alimentaria y una mejor nutrición, y promover la agricultura sostenible
03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades
09.- Desarrollar infraestructuras resilientes, promover la industrialización inclusiva y sostenible, y fomentar la innovación
12.- Garantizar las pautas de consumo y de producción sostenibles
topic Bacteriophages
Alginate hydrogel
Curcumin
Skin diseases
Drug delivery systems
02.- Poner fin al hambre, conseguir la seguridad alimentaria y una mejor nutrición, y promover la agricultura sostenible
03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades
09.- Desarrollar infraestructuras resilientes, promover la industrialización inclusiva y sostenible, y fomentar la innovación
12.- Garantizar las pautas de consumo y de producción sostenibles
description [EN] Skin disorders are often associated with oxidative stress and bacterial infections, emphasizing the need for dual therapeutic strategies. This study explores the feasibility of co-delivering the natural bioactive compound curcumin loaded in nanostructured lipid carriers (CUR-NLCs) and Staphylococcus aureus (S. aureus) bacteriophages within an alginate hydrogel matrix. The objective is to develop a multifunctional system capable of delivering both antimicrobial and antioxidant agents while preserving their bioactivity. In this regard, we first studied the stability of two structurally distinct lytic S. aureus phages, ISP (Myoviridae) and GRCS (Podoviridae), in Carbopol® and alginate hydrogels. While Carbopol® formulations significantly reduced the phage lytic activity of both phages, alginate preserved it. Subsequent analyses of alginate formulations demonstrated that co-loading the hydrogel with both phages and CUR-NLCs did not significantly impair phage infectivity. Additionally, rheological characterization confirmed that the gel maintained its viscoelastic properties, indicating favorable handling properties for topical use, such as good adhesion to the skin and ease of application. Finally, release studies revealed that the alginate hydrogel enabled the simultaneous release of both bacteriophages and curcumin, while preserving their antibacterial and antioxidant properties. These findings highlight the potential of this bifunctional co-delivery system as a novel adjuvant therapy for skin conditions, offering an effective approach for managing skin conditions where both bacterial infection and oxidative stress play critical roles.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-10-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/231565
url https://riunet.upv.es/handle/10251/231565
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023 PID2021-128213OB-I00 PARCHES DUALES PARA LA PIEL COMO PLATAFORMAS BI-FUNCIONALIZADAS CON PROPIEDADES TERAPEUTICAS ANTIBACTERIANAS Y ANTIINFLAMATORIAS
Agence Nationale de la Recherche, Francia https://doi.org/10.13039/501100001665 ANR-16-IDEX-0008
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento - No comercial (by-nc)
http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento - No comercial (by-nc)
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Association of Staphylococcus aureus bacteriophages and curcumin in alginate hydrogel: towards an advanced multifunctional co-delivery topical skin platformArmal, CaroleCalderón-Jacinto, RosaTraore, KandasDevaud, EdouardSeyer, DamienPauthe, EmmanuelMihajlovski, AgnèsRodriguez Ruiz, VioletaSoto-Prado, AlexandraRodriguez-Hernandez, Jose-Carlos|||0000-0002-1735-824XVallés Lluch, Ana|||0000-0002-7896-8666Vilariño-Feltrer, Guillermo|||0000-0002-3063-3808BacteriophagesAlginate hydrogelCurcuminSkin diseasesDrug delivery systems02.- Poner fin al hambre, conseguir la seguridad alimentaria y una mejor nutrición, y promover la agricultura sostenible03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades09.- Desarrollar infraestructuras resilientes, promover la industrialización inclusiva y sostenible, y fomentar la innovación12.- Garantizar las pautas de consumo y de producción sostenibles[EN] Skin disorders are often associated with oxidative stress and bacterial infections, emphasizing the need for dual therapeutic strategies. This study explores the feasibility of co-delivering the natural bioactive compound curcumin loaded in nanostructured lipid carriers (CUR-NLCs) and Staphylococcus aureus (S. aureus) bacteriophages within an alginate hydrogel matrix. The objective is to develop a multifunctional system capable of delivering both antimicrobial and antioxidant agents while preserving their bioactivity. In this regard, we first studied the stability of two structurally distinct lytic S. aureus phages, ISP (Myoviridae) and GRCS (Podoviridae), in Carbopol® and alginate hydrogels. While Carbopol® formulations significantly reduced the phage lytic activity of both phages, alginate preserved it. Subsequent analyses of alginate formulations demonstrated that co-loading the hydrogel with both phages and CUR-NLCs did not significantly impair phage infectivity. Additionally, rheological characterization confirmed that the gel maintained its viscoelastic properties, indicating favorable handling properties for topical use, such as good adhesion to the skin and ease of application. Finally, release studies revealed that the alginate hydrogel enabled the simultaneous release of both bacteriophages and curcumin, while preserving their antibacterial and antioxidant properties. These findings highlight the potential of this bifunctional co-delivery system as a novel adjuvant therapy for skin conditions, offering an effective approach for managing skin conditions where both bacterial infection and oxidative stress play critical roles.This work has been funded by CY Cergy Paris Universite and Universitat Politecnica de Valencia. This work was funded by CY Initiative of Excellence (grant "Investissements d Avenir" ANR-16-IDEX-0008 ») and by MCIN/AEI/10.13039/501100011033 and ERDF A way of making Europe (Grant PID2021-128213OB-I00).ElsevierDepartamento de Termodinámica AplicadaCentro de Biomateriales e Ingeniería TisularEscuela Técnica Superior de Ingeniería IndustrialAGENCIA ESTATAL DE INVESTIGACIONAgence Nationale de la Recherche, FranciaRepositorio Institucional de la Universitat Politècnica de València Riunet20252025-10-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://riunet.upv.es/handle/10251/231565reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023 PID2021-128213OB-I00 PARCHES DUALES PARA LA PIEL COMO PLATAFORMAS BI-FUNCIONALIZADAS CON PROPIEDADES TERAPEUTICAS ANTIBACTERIANAS Y ANTIINFLAMATORIASAgence Nationale de la Recherche, Francia https://doi.org/10.13039/501100001665 ANR-16-IDEX-0008open accesshttp://purl.org/coar/access_right/c_abf2Reconocimiento - No comercial (by-nc) http://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/2315652026-06-13T07:49:27Z
score 15,812429

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